Search results for "IGM"
showing 10 items of 1928 documents
Functional foods and nutraceuticals: a way to improve health, prevent disease, and delay aging. The case of cactus pear.
2007
Cactus pear fruits have recently been the object of scientific research aimed at revealing bioactive components. This short review summarizes results obtained by our group. The two characteristic betalain pigments, betanin and indicaxanthin, appear promising molecules to be considered nutraceutical compounds.
The Role of Cadherins in Ca2+-Mediated Cell Adhesion and Inherited Photoreceptor Degeneration
2002
Cadherins are Ca2+-binding, transmembrane proteins involved in cell adhesion. Recently, three cadherin molecules, cadherin-23, protocadherin-15, and cadherin-3, were found to be defective in various human diseases, many of them with photoreceptor degeneration and/or sensorineural hearing loss as major features such Usher syndrome type 1D (USH1D), USH1F, and hypotrichosis with juvenile macular dystrophy. The process, by which mutations lead to photoreceptor degeneration is still not fully understood. Data from the inner ear phenotype of USH1 mouse models suggest that loss of cell adhesion is a crucial event.
Origin, age, and significance of deep-seated granulite-facies migmatites in the Barrow zones of Scotland, Cairn Leuchan, Glen Muick area
2018
Funding for this work was provided by the Johannes-Gutenberg University of Mainz. Petrological modelling of granulite‐facies mafic and semipelitic migmatites from Cairn Leuchan, northeast Scotland, has provided new constraints on the pressure (P) and temperature (T) conditions of high‐grade metamorphism in the type‐locality Barrow zones.Phase diagrams constructed in the Na2O–CaO–K2O–FeO–MgO–Al2O3–SiO2–H2O–TiO2–O2 system have constrained the P–T conditions of peak metamorphism in the Glen Muick region of the upper‐sillimanite zone (Sill+Kfs) to have been at least ~840 ◦C at ~9 kbar (high‐pressure granulite facies). These conditions are approximately ~120 ◦C and ~3 kbar higher than those reco…
Multianalytical Approach to explain the darkening process of hematite pigment in paintings from ancient Pompeii after accelerated weathering experime…
2013
[EN] In this paper, recently excavated fresco painting fragments from the House of Marcus Lucretius (Pompeii) and not exposed to the atmosphere since the eruption of the Mount Vesuvius were subjected to a controlled SO2 atmosphere and high relative humidity. These experiments were conducted in order to simulate under accelerated conditions the possible deterioration of the hematite pigment and plaster. The mineralogical transformation of the polychromy and plaster was monitored using mainly Raman spectroscopy, a non-destructive technique, but also infrared spectroscopy (FT-IR) and scanning electron microscopy energy-dispersive X-ray spectroscopy (SEM-EDS). After different exposure cycles to…
Microbially-induced Fe and Mn oxides in condensed pelagic sediments (Middle -Upper Jurassic, Western Sicily)
2011
Abstract This article presents a petrographic comparison of the Rosso Ammonitico facies of Western Sicily and the original Rosso Ammonitico Veronese of Northern Italy based on a total of 27 sections. The Rosso Ammonitico has been the subject of numerous controversies that range from bathyal to shallow-water platform sedimentation. Therefore it seemed interesting to verify if the term Rosso Ammonitico has the same geologic connotation from region to region. The Middle-Upper Jurassic Rosso Ammonitico of Western Sicily is a condensed succession formed during a period of extensional synsedimentary tectonics related to the spreading of the Ionian Ocean. Slope-to-basin or pelagic carbonate deposi…
La docencia de Hábitat, Territorio y Medio Ambiente en el grado de Trabajo Social: una relación de aprendizaje y compromiso con el planeta
2015
El Trabajo Social necesita un verdadero cambio de paradigma que afecte al conjunto de las actividades sociales de forma transversal: profesionales, medios de comunicación, investigadoras, docentes...si queremos superar la actual situación de emergencia planetaria y trabajar por un verdadero desarrollo social sostenible e igualitario.
Autophagy and mitochondrial alterations in human retinal pigment epithelial cells induced by ethanol: implications of 4-hydroxy-nonenal
2014
Retinal pigment epithelium has a crucial role in the physiology and pathophysiology of the retina due to its location and metabolism. Oxidative damage has been demonstrated as a pathogenic mechanism in several retinal diseases, and reactive oxygen species are certainly important by-products of ethanol (EtOH) metabolism. Autophagy has been shown to exert a protective effect in different cellular and animal models. Thus, in our model, EtOH treatment increases autophagy flux, in a concentration-dependent manner. Mitochondrial morphology seems to be clearly altered under EtOH exposure, leading to an apparent increase in mitochondrial fission. An increase in 2′,7′-dichlorofluorescein fluorescenc…
Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity.
2010
Abstract Ongoing clinical trials are exploring anticancer approaches based on signaling by TRAIL, a ligand for the cell death receptors DR4 and DR5. In this study, we report on the selective apoptotic effects of multivalent DR5 binding peptides (TRAILmim/DR5) on cancer cells in vitro and in vivo. Surface plasmon resonance revealed up to several thousand-fold increased affinities of TRAILmim/DR5-receptor complexes on generation of divalent and trivalent molecules, the latter of which was achieved with a conformationally restricted adamantane core. Notably, only multivalent molecules triggered a substantial DR5-dependent apoptotic response in vitro. In tumor models derived from human embryoni…
Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin
2005
We evaluated the efficacy of a candidate melanoma vaccine approach in mice genetically prone to develop melanoma due to the introduction of an oncogenic mutation (R24C) in the germline sequence of the cyclin-dependent kinase 4 (cdk4), a protein critically involved in cell cycle regulation. Melanomas were induced in cdk4-mutant mice by chemical carcinogenesis and UVB irradiation. A genetic prime-boost strategy targeting the clinically relevant differentiation antigen tyrosinase-related protein 2 (TRP2) was performed which was able to stimulate a melanocyte-specific cellular immune response associated with localized autoimmune vitiligo-like depigmentation. However, significant destruction of …
Candida bloodstream infections in intensive care units: Analysis of the extended prevalence of infection in intensive care unit study
2011
Objectives: To provide a global, up-to-date picture of the prevalence, treatment, and outcomes of Candida bloodstream infections in intensive care unit patients and compare Candida with bacterial bloodstream infection. Design: A retrospective analysis of the Extended Prevalence of Infection in the ICU Study (EPIC II). Demographic, physiological, infection-related and therapeutic data were collected. Patients were grouped as having Candida, Gram-positive, Gram-negative, and combined Candida/bacterial bloodstream infection. Outcome data were assessed at intensive care unit and hospital discharge. Setting: EPIC II included 1265 intensive care units in 76 countries. Patients: Patients in partic…