Search results for "INOS"

Cytosolic Ca2+ and Phosphoinositide Hydrolysis Linked to Constitutively Active α1d-Adrenoceptors in Vascular Smooth Muscle

2003

In the present study, we analyzed changes in intracellular Ca2+ levels and inositol phosphate accumulation related to a population of alpha 1d-adrenoceptors in rat aorta resembling constitutively active receptors. Following intracellular Ca2+ store depletion by noradrenaline in Ca2+-free medium and removal of the agonist, restoration of extracellular Ca2+ induced four signals: a biphasic (transient and sustained) increase in [Ca2+]i, inositol phosphate accumulation, and a contractile response in the aorta. The transient increase in Ca2+, the inositol phosphate accumulation, and the contractile response were not observed in aortae incubated with prazosin or BMY 7378 [8-[2-[4-(2-methoxyphenyl…

Supplementation with d-chiro-inositol in women

2023

The world of natural compounds has been investigated with the aim of discovering possible medical applications ever since the origin of medicine. Recently, the field of gynecology has developed a growing interest regarding inositols. Inositols are cyclic polyols with a key role in many metabolic pathways. Their stability throughout the evolution of life can mark these molecules as prebiotic, due to their biochemical importance. These molecules can be classified into nine stereoisomeric compounds; among them, myo-inositol (MI) is the most important and frequent form found in nature. Inositols were first discovered in 1850 by Johanes Joseph Scherer and extracted from muscle cells, the name of…

Effects of hormonal contraception on vaginal flora, can contraceptive use lead to vulvovaginal candidiasis (VVC) or bacterial vaginosis (BV)

2016

Dacriocistitis por Candida Lusitaniae

2007

espanolCaso clinico: Se presenta el caso de una mujer de 60 anos con episodios recurrentes de dacriocistitis aguda derecha que no cedian con tratamiento medico ni tras una dacriocistorrinostomia con intubacion bicanalicular. Presento tambien una dacriocistitis izquierda que requirio una dacriocistorrinostomia. Se tomaron muestras intraoperatorias y en el cultivo aparecio Candida Lusitaniae como germen responsable. Tras tratamiento topico con Anfotericina B, asociado a dacriocistorrinostomia, la clinica desaparecio. Discusion: La dacriocistitis por Candida Lusitaniae es muy rara. Cabria preguntarse si Candida Lusitaniae es el germen primario o la dacriocistitis podria ser por sobreinfeccion …

Flower ontogeny inCapparis spinosa(Capparaceae) with special emphasis on symmetry expression

2015

The flower ontogeny of Capparis spinosa L. was studied using scanning electron microscopy (SEM) in order to shed light on the early expression of symmetry in a representative member of Capparaceae. Sepals start decussately with the abaxial and adaxial sepals, followed by the lateral ones. Petal appearance proceeds uni-directionally from the abaxial to the adaxial side. Stamens develop centrifugally on an androecial ring. Five to seven carpel lobes arise on a gynoecial ring. Monosymmetry is established in early development by the uni-directional petal appearance and is further enhanced by the acquisition of an abaxial nectary appendage and differential development of perianth organs at anthe…

Search for high-mass resonances decaying to dimuons at CDF.

2009

We present a search for high-mass neutral resonances using dimuon data corresponding to an integrated luminosity of 2.3 fb(-1) collected in pp collisions at s=1.96 TeV by the CDF II detector at the Fermilab Tevatron. No significant excess above the standard model expectation is observed in the dimuon invariant-mass spectrum. We set 95% confidence level upper limits on sigma BR(pp -> X ->mu mu), where X is a boson with spin-0, 1, or 2. Using these cross section limits, we determine lower mass limits on sneutrinos in R-parity-violating supersymmetric models, Z(') bosons, and Kaluza-Klein gravitons in the Randall-Sundrum model.

Constraints on Minute-Scale Transient Astrophysical Neutrino Sources

2019

High-energy neutrino emission has been predicted for several short-lived astrophysical transients including gamma-ray bursts (GRBs), core-collapse supernovae with choked jets, and neutron star mergers. IceCube's optical and x-ray follow-up program searches for such transient sources by looking for two or more muon neutrino candidates in directional coincidence and arriving within 100 s. The measured rate of neutrino alerts is consistent with the expected rate of chance coincidences of atmospheric background events and no likely electromagnetic counterparts have been identified in Swift follow-up observations. Here, we calculate generic bounds on the neutrino flux of short-lived transient so…

Evidence for Astrophysical Muon Neutrinos from the Northern Sky with IceCube

2015

Results from the IceCube Neutrino Observatory have recently provided compelling evidence for the existence of a high energy astrophysical neutrino flux utilizing a dominantly Southern Hemisphere dataset consisting primarily of nu_e and nu_tau charged current and neutral current (cascade) neutrino interactions. In the analysis presented here, a data sample of approximately 35,000 muon neutrinos from the Northern sky was extracted from data taken during 659.5 days of livetime recorded between May 2010 and May 2012. While this sample is composed primarily of neutrinos produced by cosmic ray interactions in the Earth's atmosphere, the highest energy events are inconsistent with a hypothesis of …

Tau neutrinos in the next decade: from GeV to EeV

2022

Tau neutrinos are the least studied particle in the standard model. This whitepaper discusses the current and expected upcoming status of tau neutrino physics with attention to the broad experimental and theoretical landscape spanning long-baseline, beam-dump, collider, and astrophysical experiments. This whitepaper was prepared as a part of the NuTau2021 Workshop.

Atmospheric and astrophysical neutrinos above 1 TeV interacting in IceCube

2015

The IceCube Neutrino Observatory was designed primarily to search for high-energy (TeV--PeV) neutrinos produced in distant astrophysical objects. A search for $\gtrsim 100$~TeV neutrinos interacting inside the instrumented volume has recently provided evidence for an isotropic flux of such neutrinos. At lower energies, IceCube collects large numbers of neutrinos from the weak decays of mesons in cosmic-ray air showers. Here we present the results of a search for neutrino interactions inside IceCube's instrumented volume between 1~TeV and 1~PeV in 641 days of data taken from 2010--2012, lowering the energy threshold for neutrinos from the southern sky below 10 TeV for the first time, far bel…