Search results for "IPR"

PANDEMIE E CONTRATTO SOCIALE. NOTE PEDAGOGICHE SULLA FORMA DEI LEGAMI NEL NOSTRO TEMPO

2021

Several are the crises generated by the pandemic. In each of these crises (health, economic, social, educational...), there are many “breaks” in the “taken for granted” that lead to ask radical questions about human life.In this horizon and according to the approach of phenomenological-hermeneutic fundamental pedagogy, the paper aims at highlighting one of the hypotheses which, starting from modernity, has been very influential: the social contract. In particular, the paper focuses on same consequences that derive from having intended the social contract as model not only of political life but also,of any possible intersubjective bond. Therefore, the paper inquiries on what the ontological …

Study of doubly strange systems using stored antiprotons

2016

Bound nuclear systems with two units of strangeness are still poorly known despite their importance for many strong interaction phenomena. Stored antiprotons beams in the GeV range represent an unparalleled factory for various hyperon-antihyperon pairs. Their outstanding large production probability in antiproton collisions will open the floodgates for a series of new studies of systems which contain two or even more units of strangeness at the PANDA experiment at FAIR. For the first time, high resolution gamma-spectroscopy of doubly strange Lambda Lambda-hypernuclei will be performed, thus complementing measurements of ground state decays of Lambda Lambda-hypernuclei at J-PARC or possible …

Desipramine induces disorder in cholesterol-rich membranes:implications for viral trafficking

2009

In this study, the effect of desipramine (DMI) on phospholipid bilayers and parvoviral entry was elucidated. In atomistic molecular dynamics simulations, DMI was found to introduce disorder in cholesterol-rich phospholipid bilayers. This was manifested by a decrease in the deuterium order parameter S(CD) as well as an increase in the membrane area. Disordering of the membrane suggested DMI to destabilize cholesterol-rich membrane domains (rafts) in cellular conditions. To relate the raft disrupting ability of DMI with novel biological relevance, we studied the intracellular effect of DMI using canine parvovirus (CPV), a virus known to interact with endosomal membranes and sphingomyelin, as …

Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC.

2007

Htid-1, the human counterpart of the Drosophila tumor suppressor gene lethal(2)tumorous imaginal discs (l(2)tid) encodes three splice forms translated into three cytosolic - Tid50, Tid48 and Tid46 - and three mitochondrial - Tid43, Tid40 and Tid38 - proteins. Here we provide evidence for the association of the endogenous Tid50/Tid48 proteins with the adenomatous polyposis coli (APC) tumor suppressor in normal colon epithelium, colorectal cancer cells and mouse NIH3T3 fibroblasts. Using the Glutathione S-transferase binding assay we show that the N-terminal region including the Armadillo domain (ARM) of APC is sufficient to bind the Tid molecules. Using immunoprecipitation and confocal micro…

Visceral leishmaniasis in a patient with Down syndrome

2006

Pozitīvas saskarsmes veicināšana pamatskolas skolēniem ar vidēji smagiem garīgās attīstības traucējumiem un agresiju

2020

Darba autore: Ieva Romančuka Darba nosaukums: Pozitīvas saskarsmes veicināšana pamatskolas skolēniem ar vidēji smagiem garīgās attīstības traucējumiem un agresiju. Darba aktualitāte: Speciālās izglītības skolotājam, strādājot ar skolēniem, kuriem ir vidēji smagi garīgās attīstības traucējumi, ikdienā bieži ir jāsaskaras ar agresiju. Agresija ietekmē visu iesaistīto emocionālo stāvokli un pārtrauc mācību darbību. Tāpēc pedagogam nepieciešamas zināšanas un prasmes kā efektīvi pārvaldīt izaicinošu uzvedību, saglabājot pozitīvu saskarsmi ar skolēnu. Darba mērķis: Izvēlēties teorijā balstītu metodi vai paņēmienu, lai veicinātu pozitīvu saskarsmi ar skolēniem, kuriem ir vidēji smagi garīgās attīs…

Aspetti etici e controllo di gestione dei farmaci antibiotici antibatterici

2010

Summary Introduction Antibacterial prescribing practices between 2004 and 2008 were investigated in the P. Giaccone University Hospital in Palermo, Italy to provide a foundation for critical analysis of the appropriateness of health-care resource usage. Materials and methods Antibiotic prescribing practices between 2004 and 2008 were analyzed in the hospital as a whole and in different specialty areas. Results were expressed as defined daily doses (DDD) as a function of bed-days, number of admissions, and Diagnosis Related Group (DRG) points. Results During the study period, increases were observed in the overall DDD per 100 bed-days (68.7 vs. 91.3) and the DDD per admission (4.53 vs. 5.54)…

Noninvasive respiratory support in the hypoxaemic peri-operative/periprocedural patient: A joint ESA/ESICM guideline.

2020

Hypoxaemia is a potential life-threatening yet common complication in the peri-operative and periprocedural patient (e.g. during an invasive procedure at risk of deterioration of gas exchange, such as bronchoscopy). The European Society of Anaesthesiology (ESA) and the European Society of Intensive Care Medicine (ESICM) developed guidelines for the use of noninvasive respiratory support techniques in the hypoxaemic patient in the peri-operative and periprocedural period. The panel outlined five clinical questions regarding treatment with noninvasive respiratory support techniques [conventional oxygen therapy (COT), high flow nasal cannula, noninvasive positive pressure ventilation (NIPPV) a…

Future hypernuclear physics at MAMI-C and PANDA-GSI

2005

Hypernuclei represent the first steps towards an extension of the periodic system into the sector of strangeness and thus add a third dimension to our evolving picture of nuclei. They provide a large variety of new and exciting perspectives ranging from new dynamical symmetries in hypernuclei spectra, non-mesonic weak decays, and the interplay of the quark-exchange and meson-exchange aspects of strong baryon–baryon forces in the flavor SU(3) world. Furthermore, double hypernuclei may provide a doorway towards exotic quark states. In the near future, electroproduction experiments at TJNAF and MAMI-C will add more detailed information on the structure of single hypernuclei states. On the long…

Phosphorylation of peroxisome proliferator-activated receptor α in rat Fao cells and stimulation by ciprofibrate

1999

The basic mechanism(s) by which peroxisome proliferators activate peroxisome proliferator-activated receptors (PPARs) is (are) not yet fully understood. Given the diversity of peroxisome proliferators, several hypotheses of activation have been proposed. Among them is the notion that peroxisome proliferators could activate PPARs by changing their phosphorylation status. In fact, it is well known that several members of the nuclear hormone receptor superfamily are regulated by phosphorylation. In this report, we show that the rat Fao hepatic-derived cell line, known to respond to peroxisome proliferators, exhibited a high content of PPARalpha. Alkaline phosphatase treatment of Fao cell lysat…