Search results for "Intestin"
showing 10 items of 2215 documents
Manifestazioni orali in corso di patologie gastrointestinali
2013
Contribution of microscopy to the study of proliferating blood cells in Ciona intestinalis immune response
2010
Following an inflammatory stimulus such as the injection of erythrocytes into the tunic of Ciona intestinalis, hemocytes respond to events occurring in the tunic within a short time, and infiltrate the inflamed tissue being massively involved in the acute inflammatory response and capsule formation. The proliferative response of circulating hemocytes and pharynx assume particular interest as it is significantly enhanced during these defence reactions. Microscopy clearly may contribute to extend our understanding of the phenomenon showing interesting mitotic figures and hematogenic nodules with proliferative characteristics.
LE CELLULE STAMINALI MESENCHIMALI IN MEDICINA RIGENERATIVA: Stato dell’arte e prospettive di applicazione sperimentale nelle malattie croniche intest…
2014
ROLE OF CHAPERONES IN HEALTHY BOWEL AND IBD.
2015
The chaperoning system is the wole complement of chaperones, co-chaperones and chaperone cofactors of the body that preserves cell and tissue homeostasis. Its structural and/or functional defects can cause pathologic conditions, nemed chaperonopathies. Large bowel homeostasis includes a healthy status of the mucosal tissues and the microbiota. An alteration of one of them may determine, in turn, modifications of the other. Molecular chaperones of bacteria and human origin have been implicated in inflammatory bowel disease (IBD). In IBD chaperone levels usually increase and their cellular and subcellular loclization change. This is considered a physiological stress-response of mucosal cells …
Human artificial membranes in (bio)analytical science: Potential for in vitro prediction of intestinal absorption-A review
2021
Abstract Artificial membranes for investigation of the human absorption (oral, dermal or respiratory) of target organic compounds are aimed at mimicking the interactions occurring at and within the cell lipid membrane. Biomolecules such as proteins are also integral components of the lipid membranes and play a pivotal role towards understanding the complex mechanisms of human absorption. In this review, we will differentiate biomimetic platforms based on static (batchwise) and dynamic modes. In the former, a synthetic membrane placed between two phases (donor and acceptor) mimics a given biological system to study permeability. Parallel artificial membrane permeation assays are the most com…
PAMPA—a drug absorption in vitro model
2004
Parallel artificial membrane permeability assay (PAMPA) was used to measure the effective permeability, P(e), as a function of pH from 4 to 10, of 17 fluoroquinolones, including three congeneric series with systematically varied alkyl chain length at the 4'N-position of the piperazine residue. The permeability values spanned over three orders of magnitude. The intrinsic permeability, P(o), and the membrane permeability, P(m), were determined from the pH dependence of the effective permeability. The pK(a) values were determined potentiometrically. The PAMPA method employed stirring, adjusted such that the unstirred water layer (UWL) thickness matched the 30-100 microm range estimated to be i…
Absorption and intestinal catabolism of fatty acids in the rat: effect of chain length and unsaturation
1991
Simultaneous portal blood absorption and intestinal mucosal catabolism of labelled fatty acids were investigated. Anaesthetized adult Wistar rats were infused intraduodenally either with 90 mumol of capric (C10:0), oleic (C18:1), linoleic (C18:2) or arachidonic (C20:4) 1-14C acids or with 30 mumol of each labelled fatty acid in addition to 30 mumol of oleic acid and 30 mumol of monopalmitin. For mixed infusates, experiments were carried out with two additional long-chain fatty acids: palmitic (C16:0) and erucic (C22:1) 1-14C acids. Radioactivity was quantified in the lipids and in the catabolic products in portal blood recovered at 5 min intervals for 1 h after infusion. At the end of the e…
Peptide-metal complexes: obtention and role in increasing bioavailability and decreasing the pro-oxidant effect of minerals.
2020
Bioactive peptides derived from food protein sources have been widely studied in the last years, and scientific researchers have been proving their role in human health, beyond their nutritional value. Several bioactivities have been attributed to these peptides, such as immunomodulatory, antimicrobial, antioxidant, antihypertensive, and opioid. Among them, metal-binding capacity has gained prominence. Mineral chelating peptides have shown potential to be applied in food products so as to decrease mineral deficiencies since peptide-metal complexes could enhance their bioavailability. Furthermore, many studies have been investigating their potential to decrease the Fe pro-oxidant effect by f…
Special issue on “Oxidative stress and redox signaling in the gastrointestinal tract and related organs”
2013
Studies on the Fibrous Components of the Test ofCiona intestinalisLinnaeus. I. Cellulose-like Polysaccharide
1977
Chemical, histochemical and electron microscopic studies on the fibrous polysaccharide component of the test of Ciona intestinalis L. were made. The results showed cellulose-like fibres to be present in the cuticle layer and in the ground substance. Bundles of fibres varying in diameter from 80 to 600 nm interweave to form a conspicuous network. The bundle appears to be formed of flat fibres, 10–13 nm in width, while the fibre is composed of fibrils 3.5–5 nm; the rectangular cross section of fibres can be supposed. The probable role of this polysaccharide is discussed.