Search results for "LEM"
showing 10 items of 23327 documents
Minimizing fleet operating costs for a container transportation company
2006
Abstract This paper focuses on a fleet management problem that arises in container trucking industry. From the container transportation company perspective, the present and future operating costs to minimize can be divided in three components: the routing costs, the resource (i.e., driver and truck) assignment costs and the container repositioning costs (i.e., the costs of restoring a given container fleet distribution over the serviced territory, as requested by the shippers that own the containers). This real-world problem has been modeled as an integer programming problem. The proposed solution approach is based on the decomposition of this problem in three simpler sub-problems associate…
Pārrobežu ceļu satiksmes negadījumiem piemērojamais likums
2017
Bakalaura darba tēma ir „Pārrobežu ceļu satiksmes negadījumos piemērojamais likums”. Bakalaura darba mērķis ir noskaidrot, kādos gadījumos tiek piemērota 1971. gada 4. maija konvencija „Konvencija par ceļu satiksmes negadījumiem piemērojamo likumu” un Eiropas Parlamenta un Padomes Regula Nr. 864/2007, un kā šie divi starptautiskie normatīvie akti mijiedarbojas un atšķiras. Kā arī, izpētīt, vai tos savā praksē pielieto apdrošinātāji. Pētāmās problēmas galvenais iemesls - apdrošinātāji, nosakot atbildību un aprēķinot apdrošināšanas atlīdzību par zaudējumiem, kas cietušajām personām radušies ceļu satiksmes negadījuma rezultātā, piemēro tās valsts likumu, kurā tas noticis, nevis meklē piemēroja…
Computational prediction of the Helitron-N2 (HeN2) transposable element in the strim1 locus of the Paracentrotus lividus genome
2011
Transposons constitute a significant component of the eukaryotic genome. Among others, Helitrons represent a novel major class of eukaryotic transposons, and are fundamentally different from classical ones in terms of their structure and mechanism of transposition [1]. In particular, Helitrons constitute ~1% of the sea urchin genome [2]. By a in silico approach focused on the genome of the Mediterranean sea urchin Paracentrotus lividus, we have predicted regions of high sequence identity to a Helitron-N2 (HeN2) element in the strim1 locus. Of interest, HeN2 sequences lies within the 5’ non coding region of the strim1a and strim1b genes, spanning from -105 to -2255 (the start codon ATG of st…
Double copies of blaKPC-3::Tn4401a on an IncX3 plasmid in Klebsiella pneumoniae successful clone ST512 from Italy
2015
ABSTRACT A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla KPC genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla KPC-3 gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla KPC-3 ::Tn 4401a caused by intramolecular transposition events were detected in the plasmid.
The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.
2021
Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Here we show that PIN1, the only phosphorylation-specific cis/trans prolyl isomerase, whose loss is associated with premature aging and AD, is essential to preserve heterochromatin. We demonstrate that this PIN1 function is conserved from Drosophila to humans and prevents…
Search for photonic signatures of gauge-mediated supersymmetry in 8TeV pp collisions with the ATLAS detector
2015
A search is presented for photonic signatures motivated by generalized models of gauge-mediated supersymmetry breaking. This search makes use of 20.3 fb[superscript −1] of proton-proton collision data at √s = 8 TeV recorded by the ATLAS detector at the LHC, and explores models dominated by both strong and electroweak production of supersymmetric partner states. Four experimental signatures incorporating an isolated photon and significant missing transverse momentum are explored. These signatures include events with an additional photon, lepton, b-quark jet, or jet activity not associated with any specific underlying quark flavor. No significant excess of events is observed above the Stand…
Estudio de seguimiento de niños con Trastorno del Espectro Autista en la adolescencia. Efectos de la comorbilidad con el Trastorno por Déficit de Ate…
2022
Introducción: la adolescencia es una etapa especialmente exigente para los jóvenes con un trastorno del espectro autista (TEA) debido al aumento de retos sociales, cognitivos y académicos. La presente investigación analizó las trayectorias evolutivas del TEA sin DI desde la infancia hasta la adolescencia. Métodos: El estudio 1 analizó sistemáticamente estudios prospectivos sobre la evolución de los síntomas característicos del autismo, las habilidades socio-adaptativas, el funcionamiento ejecutivo (FE), la teoría de la mente (ToM), las comorbilidades psiquiátricas y el rendimiento académico. El estudio 2 trató de clarificar el valor de la gravedad clínica en la evolución del autismo que cur…
Factores familiares y neuropsicológicos: implicaciones en los problemas de conducta y sociales de niños con TDAH
2013
El trastorno por déficit de atención con hiperactividad (TDAH) persiste hasta la adolescencia y la vida adulta, y se encuentra frecuentemente asociado a otros problemas y trastornos comórbidos que conjuntamente presentan repercusiones negativas a lo largo del ciclo vital. Dentro de este marco, se comprende la necesidad de realizar estudios longitudinales para conocer de forma precisa el curso del TDAH así como los diferentes factores que pueden afectar al mismo. El objetivo principal de este este estudio de seguimiento consistió en analizar las implicaciones de factores neuropsicológicos y factores del clima familiar en el curso de los problemas de conducta y sociales de niños con TDAH y en…
Pippurimuorikerho : perheväkivallalle altistuneiden lasten ryhmä turvakotikontekstissa
1999
A Band Model of Cambium Development: Opportunities and Prospects
2021
More than 60% of tree phytomass is concentrated in stem wood, which is the result of periodic activity of the cambium. Nevertheless, there are few attempts to quantitatively describe cambium dynamics. In this study, we develop a state-of-the-art band model of cambium development, based on the kinetic heterogeneity of the cambial zone and the connectivity of the cell structure. The model describes seasonal cambium development based on an exponential function under climate forcing which can be effectively used to estimate the seasonal cell production for individual trees. It was shown that the model is able to simulate different cell production for fast-, middle- and slow-growing trees under …