Search results for "Lici"
showing 10 items of 2919 documents
Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model
2012
SummaryMyotonic dystrophy type 1 (DM1) is a genetic disease caused by the pathological expansion of a CTG trinucleotide repeat in the 3' UTR of the DMPK gene. In the DMPK transcripts, the CUG expansions sequester RNA-binding proteins into nuclear foci, including transcription factors and alternative splicing regulators such as MBNL1. MBNL1 sequestration has been associated with key features of DM1. However, the basis behind a number of molecular and histological alterations in DM1 remain unclear. To help identify new pathogenic components of the disease, we carried out a genetic screen using a Drosophila model of DM1 that expresses 480 interrupted CTG repeats, i(CTG)480, and a collection of…
Molecular Effects of the CTG Repeats in Mutant Dystrophia Myotonica Protein Kinase Gene
2008
Myotonic Dystrophy type 1 (DM1) is a multi-system disorder characterized by muscle wasting, myotonia, cardiac conduction defects, cataracts, and neuropsychological dysfunction. DM1 is caused by expansion of a CTG repeat in the 3 untranslated region (UTR) of the Dystrophia Myotonica Protein Kinase (DMPK) gene. A body of work demonstrates that DMPK mRNAs containing abnormally expanded CUG repeats are toxic to several cell types. A core mechanism underlying symptoms of DM1 is that mutant DMPK RNA interferes with the developmentally regulated alternative splicing of defined pre-mRNAs. Expanded CUG repeats fold into ds(CUG) hairpins that sequester nuclear proteins including human Muscleblind-lik…
Extracellular matrix regulation of PTHrP and PTH/PTHrP receptor in a human breast cancer cell line
1999
AbstractIt was previously reported that 8701-BC breast cancer cells express the gene for parathyroid hormone-related peptide (PTHrP) and its cognate receptor (PTHrP-R), and release immunoreactive PTHrP in the extracellular medium; it was also found that PTHrP, in turn, exerts a role on the proliferative and invasive behavior in vitro of the same cell line. On the other hand, evidence has been produced that adhesion of 8701-BC cells onto different collagen substrates influences in various ways a number of phenotypic expressions, such as cell growth, motility, invasion of reconstituted basement membrane and production of lytic enzymes of the extracellular matrix (ECM). In light of these previ…
Tacit tonality - Implicit learning of context-free harmonic structure
2009
Musical knowledge, like native language knowledge, is largely implicit, being represented without awareness of its complex structures and incidentally acquired through interaction with a large number of samples. Two experiments explore implicit learning of hierarchical harmonic structures of different complexity employing an artificial grammar learning paradigm. The experiments consisted of an incidental learning phase using a distraction task, and a testing phase employing the process dissociation procedure paradigm (Jacoby, 1991). Participants performed significantly above chance and recognised adjacent and long-distance dependencies in both experiments. Confidence ratings and inclusion/e…
Multiplicity of solutions for asymptotically linear $n$-th order boundary value problems
2007
In this paper we investigate existence and multiplicity of solutions, with prescribed nodal properties, to a two-point boundary value problem of asymptotically linear $n$-th order equations. The proof follows a shooting approach and it is based on the weighted eigenvalue theory for linear $n$-th order boundary value problems
Pret nacionālajām minoritātēm vērstie likumpārkāpumi un to novēršanas problēmas policijas darbībā
2014
Anotācija Pētījumā „Pret nacionālajām minoritātēm vērstie likumpārkāpumi un to novēršanas problēmas policijas darbībā” tiek analizēts jautājums par nacionālo minoritāšu tiesībām, parādīts šo tiesību attīstības process Latvijas Republikas teritorijā; izskatīti starptautiskie un reģionālie dokumenti, spēkā esošie un arī jau atceltie Latvijas Republikas likumi, tika veikts minēto dokumentu salīdzinājums un piemērošanas prakses analīze; izpētīts nacionālo minoritāšu tiesību aizsardzības mehānisms kā Latvijas Republikā, tā arī citās Eiropas Savienības valstīs; izskatīti ieteikumi un rekomendācijas par policijas darbību daudznacionālā sabiedrībā, kurus izstrādājis Eiropas Drošības un sadarbības o…
“I want to speak like the other people” : Second language learning as a virtuous spiral for migrant women?
2017
This article contributes to scholarship on migrant women’s second language (L2) education in North America and Europe. Questioning reductionist understandings of the relationship between female migrants, their receiving communities and L2 education, the authors consider existing literature as well as their own qualitative work to investigate the challenges, opportunities and agency of migrant women. Weaving together and thematically presenting previous scholarship and qualitative data from interviews, participant observations and classroom recordings from a mixed-gender L2 adult migrant classroom in Austria and an all-women L2 migrant classroom in the United States, they trouble conceptuali…
Catalizzatori a base di nanocorni di carbonio-liquidi ionici per la conversione della CO2
2017
Nel presente lavoro sono stati impiegati nanocorni di carbonio (CNHs) come piattaforma catalitica per il design di nuovi materiali ibridi a base di sali di imidazolio per la conversione della CO2 in carbonati ciclici. A tale scopo sono stati preparati una serie di catalizzatori eterogenei mediante una procedura sintetica one-pot basata sulla polimerizzazione radicalica di vari sali di bis vinilimidazolio in presenza di nanocorni di carbonio. I suddetti materiali sono stati caratterizzati e testati con successo per la reazione di fissazione della CO2 in epossidi (Figura 1). Figura 1 Conversione della CO2 catalizzata da liquidi ionici supportati su CNHs Le performances catalitiche, valutate i…
Processing of an Audiobook in the Human Brain Is Shaped by Cultural Family Background
2022
Funding Information: Funding: This work was supported by the Academy of Finland [257811, 273469, 276643, 287474, 332309]; Jane and Aatos Erkko Foundation; Emil Aaltonen Foundation; Paulo Foundation and Russian Science Foundation grant [No: 22-48-08002]. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. Perception of the same narrative can vary between individuals depending on a listener’s previous experiences. We studied whether and how cultural family background may shape the processing of an audiobook in the human brain. During functional magnetic resonance imaging (fMRI), 48 healthy volunteers from two different cultural family backgrounds listened to an audi…
PODER, NEGOCIO Y CONFLICTIVIDAD FISCAL: EL REFORZAMIENTO DE LA AUTORIDAD DEL INTENDENTE EN LA VALENCIA DEL SIGLO XVIII
2014
Las vacilaciones con las que se procedió a la realización de las reformas fiscales en el Reino de Valencia tras la abolición de los fueros en 1707 generaron numerosos conflictos que impulsaron a la Monarquía a reforzar la autoridad del intendente. Con tal finalidad, se potenció la tramitación por la vía reservada de las decisiones que adoptaba en materia hacendística. Pero el considerable incremento de su poder que ello comportó favoreció su utilización de forma abusiva en beneficio propio o de la red clientelar articulada a su alrededor. No obstante, las relaciones que mantenía el intendente con las élites locales contribuyen a explicar el eco desigual que alcanzaron las denuncias de corru…