Search results for "Long"

Paternal uniparental disomy chromosome 14-like syndrome due a maternal de novo 160 kb deletion at the 14q32.2 region not encompassing the IG- and the…

2015

The human chromosome 14q32 carries a cluster of imprinted genes which include the paternally expressed genes (PEGs) DLK1 and RTL1, as well as the maternally expressed genes (MEGs) MEG3, RTL1as, and MEG8. PEGs and MEGs expression at the 14q32.2-imprinted region are regulated by two differentially methylated regions (DMRs): the IG-DMR and the MEG3-DMR, which are respectively methylated on the paternal and unmethylated on the maternal chromosome 14 in most cells. Genetic and epigenetic abnormalities affecting these imprinted gene clusters result in two different phenotypes currently known as maternal upd(14) syndrome and paternal upd(14) syndrome. However, only few patients carrying a maternal…

First M87 Event Horizon Telescope Results. VII. Polarization of the Ring

2021

Full list of authors: Akiyama, Kazunori; Algaba, Juan Carlos; Alberdi, Antxon; Alef, Walter; Anantua, Richard; Asada, Keiichi; Azulay, Rebecca; Baczko, Anne-Kathrin; Ball, David; Baloković, Mislav; Barrett, John; Benson, Bradford A.; Bintley, Dan; Blackburn, Lindy; Blundell, Raymond; Boland, Wilfred; Bouman, Katherine L.; Bower, Geoffrey C.; Boyce, Hope Bremer, Michael; Brinkerink, Christiaan D.; Brissenden, Roger; Britzen, Silke; Broderick, Avery E.; Broguiere, Dominique; Bronzwaer, Thomas; Byun, Do-Young; Carlstrom, John E.; Chael, Andrew; Chan, Chi-kwan; Chatterjee, Shami; Chatterjee, Koushik; Chen, Ming-Tang; Chen, Yongjun; Chesler, Paul M.; Cho, Ilje; Christian, Pierre; Conway, John E.…

P4730Underweight is associated with unfavourable short- and long-term outcomes after MitraClip therapy: a body mass index derived subgroup analysis o…

2019

Abstract Background Underweight and obesity represent classical risk factors for patients undergoing cardiac surgery or interventional treatment. The multicentre German Transcatheter Mitral Valve Interventions (TRAMI) registry comprises a large and prospectively enrolled real-world cohort of patients treated by MitraClip implantation. Aims The current analysis examines the impact of underweight, overweight and obesity on intra-hospital, short and long-term outcomes in patients treated by MitraClip therapy. Methods and results From 08/2010 until 07/2013, 799 patients (age 75.3±8.6 years, male gender 60.7%, median logistic EuroSCORE 20% [12; 31], functional mitral regurgitation (MR): 69.3%) w…

An analysis of the career development items in PISA 2012 and of their relationship to the characteristics of countries, shools, students and families

2014

Sixth Graders’ Use of Technologies in Learning, Technology Attitudes and School Well-Being

2017

1.IntroductionAlthough the Finnish educational system has gotten plenty of global attention as one of the best in the world (Sahlberg, 2014), it still faces many challenges (EU Parliament, 2015). For instance, the PISA results are diminishing, especially in rural areas and among boys (OECD, 2013). Even worse, Finnish adolescents were ranked very low on their liking for school (OECD, 2013). Consequently, reforms in teacher education and school have been suggested by emphasizing 21st Century skills, student-activating methods, inquiry-, project-, problem- and phenomenon-based learning (EU Parliament, 2015).The new national core curriculum also emphasizes on using digital technologies in schoo…

Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulation.

2014

The eukaryotic translation elongation factor eIF5A is the only protein known to contain the unusual amino acid hypusine which is essential for its biological activity. This post-translational modification is achieved by the sequential action of the enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH). The crucial molecular function of eIF5A during translation has been recently elucidated in yeast and it is expected to be fully conserved in every eukaryotic cell, however the functional description of this pathway in plants is still sparse. The genetic approaches with transgenic plants for either eIF5A overexpression or antisense have revealed some activities related to t…

Berufserziehung als lebenslange Aufgabe Vocational education as a lifelong learning task

2007

VonBerafsinhabern aller Couleurverlangtmanheuteuber die herkommlichen QualifikationenhinausEigenschaften, dieihre Tuchtigkeitauchunterdenveranderten Bedingungen dermodernen Arbeitswelt sichern sollen. Flexibilitay, Mobilitat, Innovationsbereitschaft, Kundenorientierung, Selbstmanagement sind einige der Chiffren, mit denen die „neuen“ Kompetenzen auf den Begriff gebracht (vgl. Hoff/Ewers/Petersen 2004) undin einem angereicherten Professionalitatskonzeptaufgehobenwerdensollen. PersonlichkeitsmerkmalediesesTyps habenzweifellosenormanBedeutunggewonnen,einerseitsindenStrategiender personalwirtschaftlichen Beurteilung und Auswahl von Bewerbern bei der Besetzung von freien Arbeitsplatzen, bei Befo…

Employment trajectories until midlife associate with early social role investments and current work-related well-being

2021

Applying social investment theory (SIT), we examined whether employment trajectories until midlife, with differential investments in education and employment, are associated with social investments during early life and with work-related well-being in midlife, with a special reference to potential differences between self-employment and paid work. In the Northern Finland Birth Cohort 1966 (n = 6496; 2963 men, 3533 women), life-history calendars from age 16 to 45 were used to determine the respondents’ yearly employment statuses (student, full-time employee, part-time employee, self-employed, unemployed, on parental leave, on sabbatical leave or otherwise not working). Latent class analysis …

Historical biogeography of Melastomataceae: the roles of Tertiary migration and long-distance dispersal

2001

Melastomataceae and Memecylaceae are pantropically distributed sister groups for which an ndhF gene phylogeny for 91 species in 59 genera is here linked with Eurasian and North American fossils in a molecular clock approach to biogeographical reconstruction. Nine species from the eight next-closest families are used to root phylogenetic trees obtained under maximum likelihood criteria. Melastomataceae comprise ∼3000 species in the neotropics, ∼1000 in tropical Asia, 240 in Africa, and 225 in Madagascar in 150-166 genera, and the taxa sampled come from throughout this geographic range. Based on fossils, ranges of closest relatives, tree topology, and calibrated molecular divergences, Mel…

The Philae lander mission and science overview.

2017

The Philae lander accomplished the first soft landing and the first scientific experiments of a human-made spacecraft on the surface of a comet. Planned, expected and unexpected activities and events happened during the descent, the touch-downs, the hopping across and the stay and operations on the surface. The key results were obtained during 12–14 November 2014, at 3 AU from the Sun, during the 63 h long period of the descent and of the first science sequence on the surface. Thereafter, Philae went into hibernation, waking up again in late April 2015 with subsequent communication periods with Earth (via the orbiter), too short to enable new scientific activities. The science return of the…