Search results for "Lp(a)"
showing 10 items of 657 documents
Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.
2020
Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…
Responsabilità penale dell’esercente la professione sanitaria.
2017
Lo scritto affronta la riforma della responsabilità penale dell'esercente la professione sanitaria alla luce della legge Gelli-Bianco.
Phosphodiesterase inhibition induces retinal degeneration, oxidative stress and inflammation in cone-enriched cultures of porcine retina.
2013
nherited retinal degenerations affecting both rod and cone photoreceptors constitute one of the causes 74 of incurable blindness in the developed world. Cyclic guanosine monophosphate (cGMP) is crucial in the 75 phototransduction and, mutations in genes related to its metabolism are responsible for different retinal 76 dystrophies. cGMP-degrading phosphodiesterase 6 (PDE6) mutations cause around 4e5% of the retinitis 77 pigmentosa, a rare form of retinal degeneration. The aim of this study was to evaluate whether phar- 78 macological PDE6 inhibition induced retinal degeneration in cone-enriched cultures of porcine retina 79 similar to that found in murine models. PDE6 inhibition was induced…
Geological context and micromammal fauna characterisation from the karstic infilling of La Pedrera (Albaida, Valencia, E Spain)
2020
La Pedrera is a new palaeontological site located south of the province of Valencia, between the Betic and Iberian Ranges, in a cavity filled with sediments inside a tufa formation. Roughly 260 fossil remains, corresponding to 14 taxa, have been recovered and studied from Unit III. Six rodents (Microtus sp., M. sp. gr. M. (Terricola) duodecimcostatus-lusitanicus, Microtus sp. gr. M. brecciensis-cabrerae, Arvicola sapidus, Eliomys quercinus, and Apodemus sp. gr. sylvaticusfl avicollis), one lagomorph (Oryctolagus cf. cuniculus), three insectivores (Soricinae indet., Crocidura sp., and Talpa cf. europaea) and four bats (Myotis blythii, Rhinolophus cf. ferrumequinum, Myotis bechsteinii, and Rh…
Risoluzione per mancanza di qualità e colpa del venditore
2018
Il ruolo della colpa nella disciplina della risoluzione per inadempimento
Analisi MLPA del gene CREB-binding protein (CREBBP) in un paziente con la sindrome di Rubinstein Taybi
2012
La sindrome di Rubinstein-Taybi è una rara malattia congenita autosomica dominante caratterizzata da ritardo della crescita postnatale, ritardo dello sviluppo psicomotorio, anomalie scheletriche, peculiare morfologia facciale ed un aumento del rischio oncogeno. La prevalenza alla nascita è 1 su 125.000 nati vivi. La malattia può essere associata a mutazioni nel gene che codifica per la proteina CREB-binding localizzato nella regione cromosomica 16p13.3. Recenti studi hanno dimostrato che pazienti con quoziente intellettivo basso e tratti autistici possono avere grandi delezioni. Sulla base di queste osservazioni, abbiamo usato la Multiplex Ligation-dependent Probe Amplification (MLPA) per r…
Proyecto europeo "SPRING": investigación, participación y acción prosocial. Estrategias, instrumentos y materiales para el diagnóstico y formación de…
2016
Palautteen, kannustuksen ja arvostuksen lähteillä : Sanomalehtien Liiton paikallislehtikilpailun rooli paikallisjournalismin kehittämisessä
2011
Sanomalehtien Liitto järjestää vuosittain paikallislehtikilpailun, jonka tarkoitus on parantaa paikallislehtien laatua. Kilpailussa lehdet saavat raadilta kirjallista palautetta sisällöstään, kuvituksestaan, ulkoasustaan ja mielipidekirjoituksistaan. Pro gradu -työssäni tutkin, millainen käytännön merkitys kilpailulla on paikallisjournalismin kehittäjänä. Samalla pohdin lehtien tavoitteita eli sitä, millaista hyvä paikallisjournalismi on. Vuosina 1994–2009 paikallislehtikilpailua tuomaroivat Jyväskylän yliopiston journalistiikan opiskelijat. Selvitän, miten paikallisjournalistit suhtautuivat nuorten tuomareiden palautteisiin. Ovatko lehdet toteuttaneet kehitysehdotuksia ja pitäneet raadin k…
Eiropas Savienības ārējās robežas Latvijā tiesiskā reglamentācija
2014
ANOTĀCIJA Pētījums veltīts Eiropas Savienības ārējo robežu Latvijā normatīvā regulējuma problemātikai starptautisko, Eiropas Savienības un nacionālo tiesību jomā Latvijas kā starptautisko tiesību subjekta suverenitātes, teritoriālās jurisdikcijas un valsts robežas kontekstā saistībā ar personu brīvas pārvietošanās īstenošanu Šengenas acquis (Šengenas tiesību kopuma) darbības telpā. Valsts robeža ir jebkuras valsts suverenitātes un drošības komponente. Tās pamatu veido valsts robežas režīma normatīvais regulējums, kas Eiropas Savienības tiesībās ir jāattīsta kopsakarā ar starptautiskajām tiesībām un Latvijas, tāpat kā citu Šengenas konvencijas dalībvalstu, starptautiskajām tiesiskajām saistī…