Search results for "MAM"
showing 10 items of 1679 documents
Satisfacción de las mujeres con la duración del proceso de valoración adicional en el cribado mamográfico
2011
ResumenObjetivosConocer los factores asociados a la satisfacción con la duración del proceso de valoración adicional en el cribado mamográfico.MétodosEstudio transversal descriptivo y multivariado mediante encuesta telefónica a una muestra representativa de mujeres (N=316) participantes en el Programa de Prevención del Cáncer de Mama de la Comunidad Valenciana, que requirieron valoración adicional mediante pruebas complementarias para confirmar el diagnóstico. Análisis descriptivo mediante tablas de contingencia (p<0,05) y de asociación mediante odds ratio (OR) con modelos de regresión logística (intervalo de confianza del 95% [IC95%]).ResultadosLa satisfacción con la duración del proceso f…
Mammalian cell metabolomics: Experimental design and sample preparation
2013
Metabolomics represents the global assessment of metabolites in a biological sample and reports the closest information to the phenotype of the biological system under study. Mammalian cell metabolomics has emerged as a promising tool with potential applications in many biotechnology and research areas. Metabolomics workflow includes experimental design, sampling, sample processing, metabolite analysis, and data processing. Given their influence on metabolite content and biological interpretation of data, a good experimental design and the appropriate choice of a sample processing method are prerequisites for success in any metabolomic study. The use of mammalian cells in the metabolomics f…
Induction of mitochondrial xanthine oxidase activity during apoptosis in the rat mammary gland
2006
Oxidative stress is an important signal for apoptosis to start. So far the mitochondrial respiratory chain has been considered as the major, if not the only, cause of such stress. Here we report that this is not the case. Xanthine oxidase, a O2(-) and H2O2 generating enzyme which is important in causing significant oxidative stress in the cytosol, is also present in the mitochondrial fraction of rat mammary gland. After weaning, during the involution of the mammary gland, massive apoptosis occurs. Mitochondrial xanthine oxidase activity increases and high mitochondrial H2O2 production takes place. Inhibition of xanthine oxidase activity by allopurinol, a specific inhibitor of xanthine oxida…
Sildenafil protects epithelial cell through the inhibition of xanthine oxidase and the impairment of ROS production
2009
Recent reports suggest that xanthine oxidase (XO), a modified form of the native xanthine dehydrogenase enzyme, plays an important role in various forms of ischemic and vascular injuries, inflammatory diseases, and chronic heart failure. The XO inhibitors allopurinol and its oxidation product oxypurinol held considerable promises in the treatment of these conditions both in experimental animals and in human clinical trials. More recently, an endothelium-based protective effect of sildenafil, a well-known type-5 phosphodiesterase inhibitor, has been reported in preconditioning prior to ischemia/reperfusion in healthy human subjects. Based on the structural similarities between allopurinol an…
Sulfur Dioxide Oxidation Catalyzed by Photosensitized Ytterbium Diphthalocyanine
2008
Oxidation of SO2 into SO3 was found effectively catalyzed by photosensitized ytterbium diphthalocyanine, YbPc2 (Pc = phthalocyanine ligand, C32H16N8) when performed in air-saturated dimethylformamide (DMF) solution at 20 °C. The process follows according to a multi-step complex mechanism involving chemical induction as its driving force. Excitation energy of the sandwich molecular system in YbPc2 is used to promote the reaction by creating a reactive intermediate form of the ytterbium complex hosting up to eight SO2 molecules. The conversion of SO2 proved complete.
Genetic sex determination and sex-specific lifespan in tetrapods – evidence of a toxic Y effect
2020
ABSTRACTSex-specific lifespans are ubiquitous across the tree of life and exhibit broad taxonomic patterns that remain a puzzle, such as males living longer than females in birds and vice versa in mammals. The prevailing “unguarded-X” hypothesis (UXh) explains this by differential expression of recessive mutations in the X/Z chromosome of the heterogametic sex (e.g., females in birds and males in mammals), but has only received indirect support to date. An alternative hypothesis is that the accumulation of deleterious mutations and repetitive elements on the Y/W chromosome might lower the survival of the heterogametic sex (“toxic Y” hypothesis). Here, we report lower survival of the heterog…
Abnormalities caused by chloroform and ether in the spermatogenesis of mammals [Chloroforma un ētera radītie traucējumi zīdītāju spermatogenezē]
1937
Teksts angļu valodā, kopsavilkums latviešu valodā.
Dietary exposure in utero and during lactation to a mixture of genistein and an anti-androgen fungicide in a rat mammary carcinogenesis model
2015
Endocrine disruptors may play substantial roles in the high incidence of breast cancer. We previously described how early exposure to the mixture of phytoestrogen genistein (G) and the anti-androgen vinclozolin (V) affects peripubertal mammary development. This study evaluates the carcinogenic potential of exposure to V alone or associated with G from conception until weaning in Wistar rats. Dams were exposed to V, G or GV during pregnancy/lactation. At PND50 offspring were treated with DMBA[7,12-dimethylbenz(a)anthracene]. V or GV maternal exposure decreased number of DMBA-induced mammary tumors in the offspring, without significant modifications in tumor incidence, multiplicity and latenc…
Impact of proportion on configural perception of odor mixtures in a newborn mammal
2009
International audience; Configural perception of odor mixtures appears functional early in life. Recent results underline that after the learning of a binary mixture. (AB) that blends in humans, newborn rabbits respond both to the mixture and to its components. However, after the learning of. a single component they do not generalize to the mixture. This suggests that they perceive more in the mixture than the odor of each. constituent (Coureaud et al., Physiol. Behav. 2008). Here, we pursued the assessment of their configural perception of AB, with the. aim to determine whether specific component proportions of A and B elicit the perceptual emergence of an additional odor in AB. Starting. …
Identification et caractérisation du récepteur à la flagelline (VvFLS2) et recherche du récepteur aux chito-oligosaccharides chez la vigne
2014
Pattern-recognition receptors (PRRs) play a key role in plant immunity by assuring recognition of microbe-associated molecular patterns (MAMPs), signature of microbial presence. MAMP perception constitutes the first layer of pathogen detection and activates defense mechanisms that aim to block the intruder. This study brings an insight into how grapevine (Vitis vinifera) perceives two MAMPs: the flagellin-derived flg22 peptide and chitin, which are conserved motifs occurring over the whole bacterial and fungal classes, respectively. This study analyzed MAMP-triggered early signaling events, defense gene expression and also the efficiency of elicited defense against gray mold and downy milde…