Search results for "MIME"
showing 10 items of 311 documents
Computational methods and theory for ion channel research
2022
Ion channels are fundamental biological devices that act as gates in order to ensure selective ion transport across cellular membranes; their operation constitutes the molecular mechanism through which basic biological functions, such as nerve signal transmission and muscle contraction, are carried out. Here, we review recent results in the field of computational research on ion channels, covering theoretical advances, state-of-the-art simulation approaches, and frontline modeling techniques. We also report on few selected applications of continuum and atomistic methods to characterize the mechanisms of permeation, selectivity, and gating in biological and model channels.
Klasyczna teoria dramatu i jej wychowawcze implikacje
2009
Unet, kuolema ja reaalifantasian rajat JP Koskisen Kuinka sydän pysäytetään ja Pasi Ilmari Jääskeläisen Sielut kulkevat sateessa -teoksissa
2020
Luova toiminta hermeneuttisena horisonttina : Kevin J. Vanhoozerin käsitys draamasta, eettisestä kasvusta ja oppimisesta
2018
The aim of this research is to analyze Kevin J. Vanhoozer’s theory of creative action as a hermeneutical viewpoint in the light of learning and ethical development. The method used in this research is systematic analysis. Vanhoozer’s understanding of action differs strongly from that of Marx and of Dewey. By turning to philosophical hermeneutics he finds a way through Aristotle’s drama theory where creative action is a basis for the Gadamerian horizon, but instead of fusing the horizons Vanhoozer sees it as the viewpoint of Bakhtinian outsider, which in turn provides an opportunity to critique the surrounding culture. The horizon becomes wider and clearer through improvisation and spontanei…
Sana esiintyy lihassa
2022
Kirja-arvio teoksesta Esa Kirkkopelto: Logomimesis: Tutkielma esiintyvästä ruumiista. Tutkijaliitto, Helsinki 2020. 351 s. ISBN 978-952-7093-19-1. Esa Kirkkopellon Logomimesis: tutkielma esiintyvästä ruumiista asettaa vastakkain mimetologian eli länsimaisen ajatteluperinteen pyrkimykset ottaa mimēsis, performatiivinen tai esityksellinen jäljittely ja siihen liittyvät ilmiöt, haltuun käsitteellisten ja teoreettisten diskurssien avulla ja Kirkkopellon uudisterminä lanseeraaman logomimesiksen, esityksellisen käytännön, joka ruumiillisin keinoin performoi diskurssien ja kielen toimintaa ja niiden peruuttamatonta sidosta materiaalisuuteen, ruumiin kielellisyyttä ja kielen ruumiillisuutta. Teoree…
L'arte per diritto. I primordi giuridici dell'estetica fotografica
2012
Pako hämärään : fantastisen ja mimeettisen suhteet lajiin ja rakenteeseen Johanna Sinisalon romaanissa Ennen päivänlaskua ei voi
2011
Pro gradu -tutkielmassani tarkastelen fantastisen ja mimeettisen toimintaa Johanna Sinisalon romaanissa Ennen päivänlaskua ei voi (2000). Erityisesti huomioni kiinnittyy fantastisen ja mimeettisen rooleihin lukijan ja tekstin välisissä suhteissa, teoksen rakenteessa sekä teoksen lajin muodostumisessa. Tarkasteluni teoreettisena lähtökohtana on Gilles Deleuzen aktuaalisen ja virtuaalisen käsitteiden hahmottelema ontologia. Tutkimuskohteeni Ennen päivänlaskua ei voi houkuttaa tällaiseen luentaan erilaisia rajapintoja käsittelevän tematiikkansa ja rakenteensa vuoksi. Tärkeimpinä työkaluinani toimivat fantastisen ja mimeettisen käsitteiden lisäksi deleuzelainen toiston käsite. Yksi tavoitteista…
Synthesis of novel fluorinated building blocks and α-helix peptidomimetics
2018
At its heart, the present PhD thesis is based on the premise of two important areas in modern organic chemistry: firstly, the development of new methodologies to incorporate fluorine into organic molecules; and secondly, the design and synthesis of small molecules with high therapeutic potential. The work presented in the first three chapters will therefore focus on the incorporation of fluorine into organic molecules and the synthesis of fluorinated building blocks. In each chapter, we aim to obtain biologically relevant small molecules containing fluorine atoms or fluorinated groupings. The introduction of fluorine is a commonly used method in drug discovery to fine-tune the properties of…
Biomimetic strategy towards gelatin coatings on PET. Effect of protocol on coating stability and cell-interactive properties
2019
Gelatin-modified poly(ethylene terephthalate) (PET) surfaces have been previously realized via an intermediate dopamine coating procedure that resulted in surfaces with superior haemocompatibility compared to unfunctionalized PET. The present study addresses the biocompatibility assessment of these coated PET surfaces. In this context, the stability of the gelatin coating upon exposure to physiological conditions and its cell-interactive properties were investigated. The proposed gelatin–dopamine-PET surfaces showed an increased protein coating stability up to 24 days and promoted the attachment and spreading of both endothelial cells (ECs) and smooth muscle cells (SMCs). In parallel, physi…
Visual learning in Drosophila: Application on a roving robot and comparisons
2011
Visual learning is an important aspect of fly life. Flies are able to extract visual cues from objects, like colors, vertical and horizontal distributedness, and others, that can be used for learning to associate a meaning to specific features (i.e. a reward or a punishment). Interesting biological experiments show trained stationary flying flies avoiding flying towards specific visual objects, appearing on the surrounding environment. Wild-type flies effectively learn to avoid those objects but this is not the case for the learning mutant rutabaga defective in the cyclic AMP dependent pathway for plasticity. A bio-inspired architecture has been proposed to model the fly behavior and experi…