Search results for "Malo"
showing 10 items of 815 documents
An efficient synthesis of pyrrolo[3',2':4,5]thiopyrano[3,2-b]pyridin-2-one: a new ring system of pharmaceutical interest
2012
Abstract A series of pyrrolo[3′,2′:4,5]thiopyrano[3,2- b ]pyridin-2-ones 4 was prepared in good yields by reacting enaminoketones with cyanomethylene active compounds such as phenylsulfonylacetonitrile, benzoylacetonitrile, and malononitrile. Derivatives of the title ring system were tested by the National Cancer Institute of Bethesda against a panel of about 60 human tumor cell lines, and one of them showed inhibitory activity against all cancer cell lines reaching on 48% of them GI 50 values at submicromolar level and on the majority of the remaining ones in the low micromolar concentration.
Resonant X-ray scattering in biological structure research
2007
The use of anomalous X-ray scattering of light elements like sulfur and phosphorus is of particular interest in biological structure research. These elements serve as native labels in proteins, nucleic acids and membranes. Their medium scattering power is drastically changed at their K absorption edges at wavelengths between 5 and 6 A where X-ray absorption excludes the use of open air diffractometers. The construction of a new diffractometer tunable to wavelengths between 1.2 and 7 A is presented. First results of anomalous scattering from sulfur in bacteriorhodopsin near the K absorption edge have been obtained recently. Their possible impact on crystallography will be considered. A compa…
Statics and dynamics of dense polymer systems studied by monte carlo simulation
1995
Monte Carlo simulations of coarse–grained models of macromolecules offer a unique tool to study the interplay between coil conformations, thermodynamic properties, and chain configurational relaxation and diffusion. Two examples are discussed where the chain conformation strongly differs from a gaussian coil: (i) collapsed chains in a bad solvent, where anomalous diffusion occurs in the Rouse limit and the relaxation time increases at least with the third power of chain length. (ii) Expulsion of a chain from a semidilute polymer brush. The initially stretched chain contracts to a gaussian coil and the center of mass moves outward with constant velocity until it reaches the region of the “la…
Advances in contrast variation for macromolecular structure determination by polarized neutron scattering and anomalous dispersion of synchrotron X-r…
1988
Contrast variation for macromolecular structure determination is usually achieved by isomorphous replacement of 1-H by 2-H (D) using small-angle neutron scattering (SANS). This is particularly easy in aqueous solvents. By adding heavy water the contrast of dissolved proteins, nucleic acids and membranes changes drastically. It is the region inaccesible to solvent molecules, which acts as a label. Measurements of the scattering intensity at three different scattering densities of a solvent yields the three basic scattering functions. The contrast dependence of the radius of gyration receives particular interest. More recently smaller labels have been used. Their dimensions are smaller than t…
Hadronic light-by-light scattering amplitudes from lattice QCD versus dispersive sum rules
2017
The hadronic contribution to the eight forward amplitudes of light-by-light scattering ($\gamma^*\gamma^*\to \gamma^*\gamma^*$) is computed in lattice QCD. Via dispersive sum rules, the amplitudes are compared to a model of the $\gamma^*\gamma^*\to {\rm hadrons}$ cross sections in which the fusion process is described by hadronic resonances. Our results thus provide an important test for the model estimates of hadronic light-by-light scattering in the anomalous magnetic moment of the muon, $a_\mu^{\rm HLbL}$. Using simple parametrizations of the resonance $M\to \gamma^*\gamma^*$ transition form factors, we determine the corresponding monopole and dipole masses by performing a global fit to …
Hadronic light-by-light scattering in the anomalous magnetic moment of the muon
2018
15th International Workshop on Tau Lepton Physics, Amsterdam, The Netherlands, 24 Sep 2018 - 28 Sep 2018; SciPost physics 1, 031 (2019). doi:10.21468/SciPostPhysProc.1.031
Hadronic Contributions to the Anomalous Magnetic Moment of the Muon from Lattice QCD
2021
The Standard Model of Particle Physics describes three of the four known fundamental interactions: the strong interaction between quarks and gluons, the electromagnetic interaction, and the weak interaction. While the Standard Model is extremely successful, we know that it is not a complete description of nature. One way to search for physics beyond the Standard Model lies in the measurement of precision observables. The anomalous magnetic moment of the muon \(a_\mu \equiv \frac{1}{2}(g-2)_\mu \), quantifying the deviation of the gyromagnetic ratio from the exact value of 2 predicted by the Dirac equation, is one such precision observable. It exhibits a persistent discrepancy of 3.5 standar…
Lattice calculations of the leading hadronic contribution to g-2
2012
We report on our ongoing project to calculate the leading hadronic contribution to the anomalous magnetic moment of the muon aHLO μ using two dynamical flavours of non-perturbatively O(a) improved Wilson fermions. In this study, we changed the vacuum polarisation tensor to a combination of local and point-split currents which significantly reduces the numerical effort. Partially twisted boundary conditions allow us to improve the momentum resolution of the vacuum polarisation tensor and therefore the determination of the leading hadronic contribution to (g− 2)μ . We also extended the range of ensembles to include a pion mass below 200MeV which allows us to check the non-trivial chiral behav…
Bottomonium precision tests from full lattice QCD: Hyperfine splitting, ϒ leptonic width, and b quark contribution to e+e−→hadrons
2021
We calculate the mass difference between the $\mathrm{\ensuremath{\Upsilon}}$ and ${\ensuremath{\eta}}_{b}$ and the $\mathrm{\ensuremath{\Upsilon}}$ leptonic width from lattice QCD using the highly improved staggered quark formalism for the $b$ quark and including $u$, $d$, $s$ and $c$ quarks in the sea. We have results for lattices with lattice spacing as low as 0.03 fm and multiple heavy quark masses, enabling us to map out the heavy quark mass dependence and determine values at the $b$ quark mass. Our results are ${M}_{\mathrm{\ensuremath{\Upsilon}}}\ensuremath{-}{M}_{{\ensuremath{\eta}}_{b}}=57.5(2.3)(1.0)\text{ }\text{ }\mathrm{MeV}$ (where the second uncertainty comes from neglect of …
NNLO Unquenched Calculation of the b Quark Mass
2000
By combining the first unquenched lattice computation of the B-meson binding energy and the two-loop contribution to the lattice HQET residual mass, we determine the (\bar{{MS}}) (b)-quark mass, (\bar{m}_{b}(\bar{m}_{b})). The inclusion of the two-loop corrections is essential to extract (\bar{m}_{b}(\bar{m}_{b})) with a precision of ({\cal O}(\Lambda^{2}_{QCD}/m_{b})), which is the uncertainty due to the renormalon singularities in the perturbative series of the residual mass. Our best estimate is (\bar{m}_{b}(\bar{m}_{b}) = (4.26 \pm 0.09) {\rm GeV}), where we have combined the different errors in quadrature. A detailed discussion of the systematic errors contributing to the final number …