Search results for "NAD"

The association between the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor-1 gene and extension of postsurgical calf vein …

2013

The objective of this study was to evaluate whether the presence of a plasminogen activator inhibitor type 1 (PAI-1) promoter polymorphism 4G/5G could significantly influence the proximal extension of vein thrombosis in spite of anticoagulant treatment in patients with calf vein thrombosis (CVT) following orthopaedic, urological and abdominal surgery. We studied 168 patients with CVT, who had undergone orthopaedic, urological and abdominal surgery, subdivided as follows: first, 50 patients with thrombosis progression; second, 118 patients without thrombosis progression. The 4G/5G polymorphism of the plasminogen activator inhibitor 1 was evaluated in all patients and in 70 healthy matched co…

UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling.

2003

0012-1606 doi: DOI: 10.1016/S0012-1606(03)00014-9; The unc-52 gene of Claenorhabditis elegans encodes a homologue of the basement membrane heparan sulfate proteoglycan perlecan. Viable alleles reduce the abundance of UNC-52 in late larval stages and increase the frequency of distal tip cell (DTC) migration defects caused by mutations disrupting the UNC-6/netrin guidance system. These unc-52 alleles do not cause circumferential DTC migration defects in an otherwise wild-type genetic background. The effects of unc-52 mutations on DTC migrations are distinct from effects on myofilament organization and can be partially suppressed by mutations in several genes encoding growth factor-like molecu…

Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats.

2006

Nebivolol is a β 1 -receptor antagonist with vasodilator and antioxidant properties. Because the vascular NADPH oxidase is an important superoxide source, we studied the effect of nebivolol on endothelial function and NADPH oxidase activity and expression in the well-characterized model of angiotensin II–induced hypertension. Angiotensin II infusion (1 mg/kg per day for 7 days) caused endothelial dysfunction in male Wistar rats and increased vascular superoxide as detected by lucigenin-derived chemiluminescence, as well as dihydroethidine staining. Vascular NADPH oxidase activity, as well as expression at the mRNA and protein level, were markedly upregulated, as well as NOS III uncoupled, …

The anaerobic metabolism of malate of Saccharomyces bailii and the partial purification and characterization of malic enzyme.

1982

1. The main pathway of the anaerobic metabolism of l-malate in Saccharomyces bailii is catalyzed by a l-malic enzyme. 2. The enzyme was purified more than 300-fold. During the purification procedure fumarase and pyruvate decarboxylase were removed completely, and malate dehydrogenase and oxalacetate decarboxylase were removed to a very large extent. 3. Manganese ions are not required for the reaction of malic enzyme of Saccharomyces bailii, but the activity of the enzyme is increased by manganese. 4. The reaction of l-malic enzyme proceeds with the coenzymes NAD and (to a lesser extent) NADP. 5. The Km-values of the malic enzyme of Saccharomyces bailii were 10 mM for l-malate and 0.1 mM for…

Lobo Cabrera, Manuel: Doña Juana de Austria. La princesa gobernadora

2021

Pequeña y mediana empresa en el mundo rural medieval. Formas de organización de la producción. Ejemplos del País Valenciano (s. XV)

2020

El presente estudio analiza el concepto empresa aplicado al periodo medieval, e intenta un mínimo recorrido historiográfico por aquellos autores que se han acercado a la «Business History». Además intenta una reconstrucción de los distintos tipos de empresa manufacturera en un ámbito rural que se nos muestra cada vez más dinámico, pero poco estudiado todavía por parte de los historiadores interesados en el mundo del artesanado y de la industria. Se estudian las distintas formas de organización de la producción que condicionan los diferentes modos de gestión de la empresa manufacturera tomando como referencia el espacio valenciano. This article analyses the concept of «enterprise» as applied…

Special Issue on Higher education and its clients : institutional responses to changes in demand and in environment

2002

02048

ALLOPURINOL BLOCKS AORTIC ANEURYSM IN A MOUSE MODEL OF MARFAN SYNDROME VIA REDUCING AORTIC OXIDATIVE STRESS

2022

ABSTRACTBackgroundIncreasing evidence indicates that redox stress participates in MFS aortopathy, though its mechanistic contribution is little known. We reported elevated reactive oxygen species (ROS) formation and NADPH oxidase NOX4 upregulation in MFS patients and mouse aortae. Here we address the contribution of xanthine oxidoreductase (XOR), which catabolizes purines into uric acid and ROS in MFS aortopathy.Methods and ResultsIn aortic samples from MFS patients, XOR protein expression, revealed by immunohistochemistry, increased in both the tunicae intima and media of the dilated zone. In MFS mice (Fbn1C1041G/+), aortic XOR mRNA transcripts and enzymatic activity of the oxidase form (X…

Visões dos agentes envolvidos na concepção, divulgação e utilização de materiais educativos digitais nos portais educativos espanhóis

2019

Este artículo recoge resultados de un estudio más amplio dedicado al análisis de las visiones de los agentes y actores implicados en el diseño, difusión y utilización de los materiales digitales educativos presentes en portales educativos españoles que ofertan servicios y recursos educativos. Forma parte, a su vez, de un proyecto de I+D+i, denominado “Escuela Digital”, dedicado al análisis de la producción y uso de contenidos didácticos digitales en los centros escolares1. El propósito principal del artículo es presentar los resultados de las visiones del profesorado, el alumnado y las familias sobre los materiales digitales presentes en los portales institucionales de Galicia y Valencia, o…

A comparative study of photocatalytically active nanocrystalline tetragonal T zyrcon- type and monoclinic scheelite-type bismuth vanadate

2018

The authors from Vinča Institute of Nuclear Sciences acknowledge the financial support of the Ministry of Education, Science and Technological Development of the Republic of Serbia (Project no: 172056 ). The work of K. Smits was supported by Latvian National Research Program IMIS2 (Grant no. 302/2012 ).