Search results for "ORAL SQUAMOUS CELL CARCINOMA"

showing 10 items of 50 documents

A CASE REPORT OF 2 METACHRONOUS ORAL SQUAMOUS CELL CARCINOMAS AND 1 RECURRENCE IN 7 YEARS

2022

ORAL SQUAMOUS CELL CARCINOMAS FIELD CANCERIZATION SYNCHRONOUS TUMOR METACHRONOUS TUMOR
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Biopsy vs. brushing: comparison of two sampling methods for the detection of HPV-DNA in squamous cell carcinoma of the oral cavity

2012

Background: HR HPV infection was proposed as aetiological factor of oral squamous cell carcinomas (OSCC). HPV frequency in OSCC is highly variable, due to the discrepancy in oral sampling procedures, HPV testing methods and inclusion criteria regarding tumour site (strictly oral cavity vs. nearby structures). Our aim was to compare HPV DNA frequency and type-specific distribution in paired cytological and histological samples of SCC strictly located in oral cavity. The correlation between HPV detection rate by each method of sampling and demographical, behavioural and clinical-pathological variables was also examined. Patients and methods: HPV DNA was detected in brushed cells and formalin-…

OncologyAdultMaleCancer Researchmedicine.medical_specialtyPathologySettore MED/07 - Microbiologia E Microbiologia ClinicaConcordanceBiopsyBiologySettore MED/08 - Anatomia PatologicaOral cavitySettore MED/28 - Malattie OdontostomatologicheInternal medicineStatistical significanceGenotypeBiopsymedicineCarcinomaHumansPapillomaviridaeAgedAged 80 and overmedicine.diagnostic_testHPV infectionMiddle Agedmedicine.diseasestomatognathic diseasesHpv testingBiopsy Brushing Human Papilloma Virus (HPV) infection Methods of sampling Oral squamous cell carcinoma (OSCC) Tonsillar squamous cell carcinoma (TSCC) Oropharyngeal squamous cell carcinoma(OPSCC) Head and neck squamous cell carcinoma(HNSCC) Oral cavityOncologyDNA ViralCarcinoma Squamous CellFemaleMouth NeoplasmsOral Surgery
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Expression of sexual hormones receptors in oral squamous cell carcinoma.

2011

Sexual hormones play an important role in expression of genes involved in a wide variety of biological and neoplastic processes. The information on Estrogen Receptors (ER) expression in non-target tissues is very few and, in particular, the studies in head and neck tumors are still controversial. Recent studies analyzed the role of Tamoxifen (TAM) on Oral Squamous Cell Carcinoma (OSCC) lines in relation to the presence/absence of ER. The purpose of the present study was to evaluate the expression of sexual hormones receptors mRNAs, in particular Estrogen Receptor alpha (ERα) and Androgen Receptor (AR) mRNA in OSCC tissues. The study group comprised 20 samples of OSCC, harvested from 20 oth…

OncologyAdultMalemedicine.medical_specialtyImmunologyEstrogen receptorBiologyOral Squamous Cell CarcinomaSettore MED/28 - Malattie OdontostomatologicheEstrogen ReceptorsInternal medicinemedicineCarcinomaImmunology and AllergyHumansAndrogen Receptors; Estrogen Receptors; Oral Squamous Cell Carcinoma;Oral mucosaReceptorAgedPharmacologyOral squamous cell carcinoma estrogen receptorsAndrogen receptorEstrogen Receptor alphaCancerMiddle Agedmedicine.diseaseAndrogen receptormedicine.anatomical_structureReceptors AndrogenCase-Control StudiesCancer researchCarcinoma Squamous CellFemaleMouth NeoplasmsEstrogen receptor alphaTamoxifenmedicine.drugSexual hormones OSCCAndrogen Receptors
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Effect of c-Met expression on survival in head and neck squamous cell carcinoma

2005

The proto-oncogene c-Met has been suggested to be associated with progression of squamous cell carcinoma of the head and neck. The aims of the present study were to assess the prevalence of c-Met expression in oral squamous cell carcinoma (OSCC) and to verify whether c-Met can be considered a marker of prognosis in these patients. In a retrospective study, a cohort of 84 OSCC patients was investigated for c-Met expression and its cellular localization by immunohistochemistry. After grouping for c-Met expression, OSCC patients were statistically analyzed for the variables age, gender, histological grading, tumor node metastasis, staging and overall survival rate. Univariate and multivariate …

OncologyAdultMalemedicine.medical_specialtyc-Met; Cox regression analysis; Oral squamous cell carcinoma;C-MetAdolescentcox regression analysisProto-Oncogene Maschemistry.chemical_compoundInternal medicinemedicineBiomarkers TumorHumansBasal cellHead and neckc-MetNeoplasm Stagingbusiness.industryMouth MucosaGeneral MedicineMiddle AgedProto-Oncogene Proteins c-metmedicine.diseasePrognosisHead and neck squamous-cell carcinomaImmunohistochemistryUp-Regulationoral squamous cell carcinomastomatognathic diseaseschemistryCarcinoma Squamous CellFemaleMouth Neoplasmsbusiness
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Low Frequency of Human Papillomavirus in Strictly Site-Coded Oral Squamous Cell Carcinomas, Using the Latest NHI/SEER-ICD Systems: A Pilot Observatio…

2021

Simple Summary The incidence of oropharyngeal squamous cell carcinomas (OPSCCs) has increased in the last decades, and this seems to be correlated to the infectious epidemiological trend of human papillomavirus (HPV). The prevalence of HPV-positive OPSCCs is approximately 70%, with involvement mainly of the tonsillar area. On the role of HPV in oral squamous cell carcinoma (OSCC), very few studies have investigated the prevalence of HPV in strictly site-codified OSCC, excluding the base of the tongue as distinct oropharyngeal entity. As a result, an inappropriate estimation of HPV infection in OSCC has been observed. We investigated HPV status, using a combination of detection methods, in a…

OncologyCancer Researchmedicine.medical_specialtyCellmedicine.disease_causeArticleInternal medicineNIH/SEER ICD-0-3.2EpidemiologymedicineHuman papillomavirushuman papillomavirusRC254-282Human papillomavirus oral squamous cell carcinoma NIH7 SEER ICD-0-3.2p16 IHCPCR HPV-DNAbusiness.industryHPV infectionNeoplasms. Tumors. Oncology. Including cancer and carcinogensCancervirus diseasesmedicine.diseaseoral squamous cell carcinomastomatognathic diseasesmedicine.anatomical_structurePCR HPV-DNA P16 ihcOncologyImmunohistochemistryObservational studybusinessCarcinogenesisCancers
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Expression of cell cycle markers and human papillomavirus infection in oral squamous cell carcinoma: use of fuzzy neural networks.

2005

Our aim was to evaluate in oral squamous cell carcinoma (OSCC) the relationship between some cell cycle markers and HPV infection, conditionally to age, gender and certain habits of patients, and to assess the ability of fuzzy neural networks (FNNs) in building up an adequate predictive model based on logic inference rules. Eighteen cases of OSCC were examined by immunohistochemistry for MIB-1, PCNA and survivin expression; presence of HPV DNA was investigated in exfoliated oral mucosa cells by nested PCR (nPCR, MY09-MY11/GP5-GP6), and HPV genotype was determined by direct DNA sequencing. Data were analyzed by traditional statistics (TS) and FNNs. HPV DNA was found in 9/18 OSCCs (50.0 %) wi…

OncologyMaleCancer ResearchSurvivinmedicine.disease_causeInhibitor of Apoptosis ProteinsRisk FactorsOral mucosaPapillomaviridaeAged 80 and overCell CycleSmokingHPV infectionAge FactorsAnatomical pathologyCell cycleMiddle AgedImmunohistochemistryNeoplasm Proteinsoral squamous cell carcinomamedicine.anatomical_structureCell Transformation NeoplasticOncologyCarcinoma Squamous CellImmunohistochemistryFemaleMouth NeoplasmscarcinogenesisMicrotubule-Associated ProteinsAdultmedicine.medical_specialtyBiologySex FactorsFuzzy LogicInternal medicineSurvivinmedicineHumanshuman papillomaviruAgedfuzzy neural networkGene Expression ProfilingPapillomavirus Infectionsmedicine.diseaseProliferating cell nuclear antigenstomatognathic diseasesImmunologyDNA Viralbiology.proteinNeural Networks ComputerCarcinogenesisInternational journal of cancer
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HPV in oral squamous cell carcinoma vs head and neck squamous cell carcinoma biopsies: a meta-analysis (1988-2007).

2008

Abstract INTRODUCTION: In the literature, there exists a wide range of human papillomavirus (HPV) DNA prevalence for head and neck squamous cell carcinoma (HNSCC), especially in relation to methods of viral detection and the lesion site. We estimated the pooled prevalence of HPV DNA in biopsies of HNSCC generically grouped versus oral squamous cell carcinoma (OSCC) in relation to the method of viral DNA detection, with the primary end point of verifying if these two variables (specification of tumour site and method of HPV DNA identification) influence the datum on HPV assay. METHODS: By means of MEDLINE/PubMED/Ovid databases, we selected studies examining paraffin-embedded (PE) biopsies of…

Oncologymedicine.medical_specialtyPathologyHPV/ oral squamous cell carcinoma/ head and neck squamous cell carcinomaSettore MED/06 - Oncologia MedicaBiopsySettore MED/50 - Scienze Tecniche Mediche ApplicatePolymerase Chain ReactionSettore MED/01 - Statistica Medicalaw.inventionlawInternal medicineBiopsymedicineCarcinomaHumansPapillomaviridaePolymerase chain reactionIn Situ Hybridizationmedicine.diagnostic_testbusiness.industryHead and neck cancerPapillomavirus InfectionsCancerAnatomical pathologyHematologymedicine.diseaseHead and neck squamous-cell carcinomastomatognathic diseasesOncologyHead and Neck NeoplasmsDNA ViralCarcinoma Squamous CellMouth NeoplasmsViral diseasebusinessAnnals of oncology : official journal of the European Society for Medical Oncology
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Clinical Validation of 13-gene DNA Methylation Analysis from Oral Brushing: A Non Invasive Sampling Procedure for Early Detection of Oral Squamous Ce…

2019

In a recent study our research group described a non-invasive sampling procedure based on [...]

Oncologymedicine.medical_specialtyoral brushing;oral squamous cell carcinoma; quantitative DNA methylation analysisbusiness.industryEarly detectionSampling (statistics)oral brushingoral squamous cell carcinomaInternal medicineDNA methylationMedicinequantitative DNA methylation analysisBasal cellGene DNA Methylation Analysis Oral Brushing Non Invasive Sampling Early Detection Oral Squamous Cell CarcinomabusinessNon invasive samplingGeneThe XV National and III International Congress of the Italian Society of Oral Pathology and Medicine
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Oral squamous cell carcinoma mimicking osteonecrosis of the jaw: a case report

2021

Oral squamous cell carcinoma osteonecrosis of the jaw case report
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ANP differentiates between primary Submandibular Gland Squamous Cell Carcinoma and Oral Squamous Cell Carcinoma: Preliminary data

2021

The natriuretic peptide system consists of three ligands, Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors (NPR’s), NPRA, NPRB and NPRC. We investigated the expression levels of NPPA (encoding ANP) and NPR1 (encoding NPRA, the main receptor for ANP) in primary benign (pleomorphic adenoma) and malignant (squamous cell carcinoma, SCC) submandibular salivary gland (SMG) tumors, as well as in primary oral squamous cell carcinoma (OSCC). We found that the NPPA and NPR1 expression levels were significantly different in SMG SCC versus OSCC, exhibiting a significant increase in NPPA and absence of NPR1 ex…

Settore BIO/17 - IstologiaOral squamous cell carcinomaAtrial natriuretic peptide ANPNPPANatriuretic peptide receptor A NPRASubmandibular gland squamous cell carcinomaSubmandibular gland pleomorphic adenoma.
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