Search results for "PD"
showing 10 items of 1971 documents
PD-1/PD-L1 immune-checkpoint blockade induces immune effector cell modulation in metastatic non-small cell lung cancer patients: A single-cell flow c…
2022
Peripheral immune-checkpoint blockade with mAbs to programmed cell death receptor-1 (PD-1) (either nivolumab or pembrolizumab) or PD-Ligand-1 (PD-L1) (atezolizumab, durvalumab, or avelumab) alone or in combination with doublet chemotherapy represents an expanding treatment strategy for metastatic non-small cell lung cancer (mNSCLC) patients. This strategy lays on the capability of these mAbs to rescue tumor-specific cytotoxic T lymphocytes (CTLs) inactivated throughout PD-1 binding to PD-L1/2 in the tumor sites. This inhibitory interactive pathway is a physiological mechanism of prevention against dangerous overreactions and autoimmunity in case of prolonged and/or repeated CTL response to …
Optimal Heating of an Indoor Swimming Pool
2020
This work presents the derivation of a model for the heating process of the air of a glass dome, where an indoor swimming pool is located in the bottom of the dome. The problem can be reduced from a three dimensional to a two dimensional one. The main goal is the formulation of a proper optimization problem for computing the optimal heating of the air after a given time. For that, the model of the heating process as a partial differential equation is formulated as well as the optimization problem subject to the time-dependent partial differential equation. This yields the optimal heating of the air under the glass dome such that the desired temperature distribution is attained after a given…
Optimality of Increasing Stability for an Inverse Boundary Value Problem
2021
In this work we study the optimality of increasing stability of the inverse boundary value problem (IBVP) for the Schrödinger equation. The rigorous justification of increasing stability for the IBVP for the Schrödinger equation were established by Isakov [Discrete Contin. Dyn. Syst. Ser. S, 4 (2011), pp. 631--640] and by Isakov et al. [Inverse Problems and Applications, Contemp. Math. 615, American Math Society, Providence, RI, 2014, pp. 131--141]. In [Discrete Contin. Dyn. Syst. Ser. S, 4 (2011), pp. 631--640] and [Inverse Problems and Applications, Contemp. Math. 615, American Math Society, Providence, RI, 2014, pp. 131--141], the authors showed that the stability of this IBVP increases …
Formation and growth of palladium nanoparticles inside porous poly(4-vinyl-pyridine) monitored by operando techniques: The role of different reducing…
2017
In this work we followed the formation of palladium nanoparticles, starting from palladium (II) acetate precursor, inside a poly(4-vinylpyridine-co-divinylbenzene) polymer in presence of different reducing agents. The formation and growth of palladium nanoparticles in presence of H-2 was followed as a function of temperature by simultaneous XANES-SAXS techniques, coupled with DRIFT spectroscopy in operando conditions. It was found that the pyridyl functional groups in the polymer plays a fundamental role in the stabilization of the palladium (II) acetate precursor, as well as in the stabilization of the palladium nanoparticles. The effect of a thermal treatment in alcohol (ethanol and 2-pro…
Unique continuation results for certain generalized ray transforms of symmetric tensor fields
2022
Let $I_{m}$ denote the Euclidean ray transform acting on compactly supported symmetric $m$-tensor field distributions $f$, and $I_{m}^{*}$ be its formal $L^2$ adjoint. We study a unique continuation result for the normal operator $N_{m}=I_{m}^{*}I_{m}$. More precisely, we show that if $N_{m}$ vanishes to infinite order at a point $x_0$ and if the Saint-Venant operator $W$ acting on $f$ vanishes on an open set containing $x_0$, then $f$ is a potential tensor field. This generalizes two recent works of Ilmavirta and M\"onkk\"onen who proved such unique continuation results for the ray transform of functions and vector fields/1-forms. One of the main contributions of this work is identifying t…
Multi-parameter analysis of the obstacle scattering problem
2022
Abstract We consider the acoustic field scattered by a bounded impenetrable obstacle and we study its dependence upon a certain set of parameters. As usual, the problem is modeled by an exterior Dirichlet problem for the Helmholtz equation Δu + k 2 u = 0. We show that the solution u and its far field pattern u ∞ depend real analytically on the shape of the obstacle, the wave number k, and the Dirichlet datum. We also prove a similar result for the corresponding Dirichlet-to-Neumann map.
Apdāvināto sākumskolas bērnu attīstība diferencētā mācību procesā
2018
Diplomdarba tēma ir Apdāvinātie skolas vecuma bērni diferencētā mācību procesā. Darbs tika izstrādāts ar mērķi teorētiski noskaidrot un empīriski pārbaudīt apdāvināto sākumskolas bērnu iekļaušanos mācību procesā. Darba autore, strādājot vispārizglītojošā skolā par sākumskolas skolotāju, novēroja, ka vienas klases skolēni ,kuriem ir vienāds vecums, ir ļoti atšķirīgi mācību procesā. Līdz ar to, darba autores uzmanība tika piesaistīta skolēniem, kuri izceļas no saviem klasesbiedriem ar uzvedību un mācīšanās problēmām. Tajā pašā laikā mācību sasniegumi tieši šiem skolēniem ir augstāki, nekā pārējiem. Darba autore pētīja mācību metodes, kas veicina apdāvināta skolēna intelektuālo spēju attīstīša…
Starpdisciplinārās komandas sadarbības modelis bērnu psihoneiroloģiskajā slimnīcā
2022
Maģistra darba tēma “Starpdisciplinārās komandas sadarbības modelis bērnu psihoneiroloģiskajā slimnīcā”. Tēmas aktualitāte saistās ar identificēto problēmu, ka stacionāros ārstēšanas procesā nav iesaistīta starpdisciplinārā komanda. Pētījuma mērķis izvērtēt starpdisciplinārās komandas sadarbības modeļa efektivitāti bērnu psihoneiroloģiskajā slimnīcā. Izvirzīti pētījuma jautājumi: kā starpdisciplinārās komandas dalībnieki vērtē savstarpējo sadarbību komandā un kā veicināt sadarbības modeļa efektivitāti. Pētījumā izmantota kvalitatīvā pētniecības metode, pētījuma instrumenti - daļēji strukturēta intervija un fokusgrupas intervija. Pētījumā piedalījās 18 starpdisciplinārās komandas dalībnieki.…
Partial data inverse problems and simultaneous recovery of boundary and coefficients for semilinear elliptic equations
2021
We study various partial data inverse boundary value problems for the semilinear elliptic equation $\Delta u+ a(x,u)=0$ in a domain in $\mathbb R^n$ by using the higher order linearization technique introduced in [LLS 19, FO19]. We show that the Dirichlet-to-Neumann map of the above equation determines the Taylor series of $a(x,z)$ at $z=0$ under general assumptions on $a(x,z)$. The determination of the Taylor series can be done in parallel with the detection of an unknown cavity inside the domain or an unknown part of the boundary of the domain. The method relies on the solution of the linearized partial data Calder\'on problem [FKSU09], and implies the solution of partial data problems fo…
Quantitative Runge Approximation and Inverse Problems
2017
In this short note we provide a quantitative version of the classical Runge approximation property for second order elliptic operators. This relies on quantitative unique continuation results and duality arguments. We show that these estimates are essentially optimal. As a model application we provide a new proof of the result from \cite{F07}, \cite{AK12} on stability for the Calder\'on problem with local data.