Search results for "PDE"
showing 10 items of 558 documents
Relaxation induced by cGMP phosphodiesterase inhibitors sildenafil and zaprinast in human vessels
2000
Abstract Background . Sildenafil is currently used in the treatment of erectile dysfunction. However, assessment of direct effects of sildenafil on coronary arteries and on arteries used as coronary grafts is unknown. This study was designed to investigate the effects of sildenafil on contracted human coronary, internal mammary, and radial arteries obtained from multiorgan donors. The observations were extended to forearm veins. Zaprinast was included in this study for comparison. Methods . Segments of left coronary, internal mammary, and radial arteries, and forearm veins were obtained from 16 multiorgan donors. Vascular rings were suspended in organ bath chambers and isometric tension was…
A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample
2011
Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium). OBJECTIVES: To comprehensively analyse previously reported genetic associations with lung function measures, and to investigate whether single nucleotide polymorphisms (SNPs) in these genomic regions…
Some overdetermined problems related to the anisotropic capacity
2018
Abstract We characterize the Wulff shape of an anisotropic norm in terms of solutions to overdetermined problems for the Finsler p-capacity of a convex set Ω ⊂ R N , with 1 p N . In particular we show that if the Finsler p-capacitary potential u associated to Ω has two homothetic level sets then Ω is Wulff shape. Moreover, we show that the concavity exponent of u is q = − ( p − 1 ) / ( N − p ) if and only if Ω is Wulff shape.
Parameter dependence for the positive solutions of nonlinear, nonhomogeneous Robin problems
2020
We consider a parametric nonlinear Robin problem driven by a nonlinear nonhomogeneous differential operator plus an indefinite potential. The reaction term is $$(p-1)$$-superlinear but need not satisfy the usual Ambrosetti–Rabinowitz condition. We look for positive solutions and prove a bifurcation-type result for the set of positive solutions as the parameter $$\lambda >0$$ varies. Also we prove the existence of a minimal positive solution $$u_\lambda ^*$$ and determine the monotonicity and continuity properties of the map $$\lambda \rightarrow u_\lambda ^*$$.
Harnack's inequality for p-harmonic functions via stochastic games
2013
We give a proof of asymptotic Lipschitz continuity of p-harmonious functions, that are tug-of-war game analogies of ordinary p-harmonic functions. This result is used to obtain a new proof of Lipsc...
A priori bounds and multiplicity of solutions for an indefinite elliptic problem with critical growth in the gradient
2019
Let $\Omega \subset \mathbb R^N$, $N \geq 2$, be a smooth bounded domain. We consider a boundary value problem of the form $$-\Delta u = c_{\lambda}(x) u + \mu(x) |\nabla u|^2 + h(x), \quad u \in H^1_0(\Omega)\cap L^{\infty}(\Omega)$$ where $c_{\lambda}$ depends on a parameter $\lambda \in \mathbb R$, the coefficients $c_{\lambda}$ and $h$ belong to $L^q(\Omega)$ with $q>N/2$ and $\mu \in L^{\infty}(\Omega)$. Under suitable assumptions, but without imposing a sign condition on any of these coefficients, we obtain an a priori upper bound on the solutions. Our proof relies on a new boundary weak Harnack inequality. This inequality, which is of independent interest, is established in the gener…
Principal eigenvalue of a very badly degenerate operator and applications
2007
Abstract In this paper, we define and investigate the properties of the principal eigenvalue of the singular infinity Laplace operator Δ ∞ u = ( D 2 u D u | D u | ) ⋅ D u | D u | . This operator arises from the optimal Lipschitz extension problem and it plays the same fundamental role in the calculus of variations of L ∞ functionals as the usual Laplacian does in the calculus of variations of L 2 functionals. Our approach to the eigenvalue problem is based on the maximum principle and follows the outline of the celebrated work of Berestycki, Nirenberg and Varadhan [H. Berestycki, L. Nirenberg, S.R.S. Varadhan, The principal eigenvalue and maximum principle for second-order elliptic operator…
A min-max principle for non-differentiable functions with a weak compactness condition
2009
A general critical point result established by Ghoussoub is extended to the case of locally Lipschitz continuous functions satisfying a weak Palais-Smale hypothesis, which includes the so-called non-smooth Cerami condition. Some special cases are then pointed out.
Symmetry for positive critical points of Caffarelli–Kohn–Nirenberg inequalities
2022
Abstract We consider positive critical points of Caffarelli–Kohn–Nirenberg inequalities and prove a Liouville type result which allows us to give a complete classification of the solutions in a certain range of parameters, providing a symmetry result for positive solutions. The governing operator is a weighted p -Laplace operator, which we consider for a general p ∈ ( 1 , d ) . For p = 2 , the symmetry breaking region for extremals of Caffarelli–Kohn–Nirenberg inequalities was completely characterized in Dolbeault et al. (2016). Our results extend this result to a general p and are optimal in some cases.
Asymptotic Behaviors of Solutions to quasilinear elliptic Equations with critical Sobolev growth and Hardy potential
2015
Abstract Optimal estimates on the asymptotic behaviors of weak solutions both at the origin and at the infinity are obtained to the following quasilinear elliptic equations − Δ p u − μ | x | p | u | p − 2 u = Q ( x ) | u | N p N − p − 2 u , x ∈ R N , where 1 p N , 0 ≤ μ ( ( N − p ) / p ) p and Q ∈ L ∞ ( R N ) .