Search results for "PENTAD"

showing 10 items of 589 documents

Cyclopentadienylmolybdenum(VI) and molybdenum(V) oxo chemistry: New synthetic and structural features

2002

International audience; Convenient syntheses for Cp, Cp*, and related cyclopentadienyl derivatives (4Cp = C5HiPr4; Cp′′′ = C5H2tBu3-1,2,4) of formula [(Ring)2Mo2O5] are described. Compound [Cp2Mo2O5] was produced in good yields by the rapid oxidation of red [CpMoO2]4 with PhIO in CH2Cl2. [Cp*2Mo2O5] was obtained by CH3COOH acidification of aqueous solutions of [Cp*MoO3]−Na+, the latter being generated in a single step from [Cp*MoCl4] and more than 5 equiv. of aqueous NaOH in air. Minor quantities of [Cp*MoO2]2 were also isolated from this reaction, although the formation of this by-product may be reduced by using a two-step basic hydrolysis procedure. Extension of the latter strategy also a…

MolybdenumAqueous solutionChemistrychemistry.chemical_elementBasic hydrolysisSingle stepRing (chemistry)Oxo ligandsMedicinal chemistryInorganic ChemistryCyclopentadienyl complexMolybdenumX-ray crystallography[CHIM.CRIS]Chemical Sciences/CristallographyOrganic chemistry[CHIM.COOR]Chemical Sciences/Coordination chemistryCyclopentadienyl ligandsX-ray crystallography
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1971

The polymerisation of ethylene was carried out in the presence of (C5H5)2TiCl2/(C2H5)2AlCl in benzene (I) and of TiCl4/(C2H5)AlCl2 in chlorobenzene (II). In the initial state of the polymerisation with I oligomers with a narrow molecular weight distribution are formed. According to their IR and NMR spectra they were identified as predominantly saturated linear hydrocarbons. The effect of a substitution of the cyclopentadienyl rings by R = CH3 and C2H5 was studied as well as the influence of aging particularly on the molecular weight distribution. The catalytic system II yields predominantly unsaturated branched oligomers with broad molecular weight distribution. The ligand effect on the str…

NMR spectra databasechemistry.chemical_compoundEthylenechemistryCyclopentadienyl complexPolymerizationChlorobenzeneLigandPolymer chemistryMolar mass distributionBenzeneDie Makromolekulare Chemie
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Opioid switching from and to tapentadol extended release in cancer patients: conversion ratio with other opioids

2013

Objectives: The aim of this exploratory study was to assess the conversion ratios between tapentadol and other opioids in patients requiring an opioid switching. Methods: A prospective study was carried out in a convenience sample of consecutive patients admitted to an acute palliative care unit and a home care unit for a period of 1 year. Patients who were switched from/to tapentadol were selected. The initial ratio between tapentadol and other opioids, expressed as oral morphine equivalents was 1:3.3. The subsequent doses were flexible and were changed to fit the patients’ needs. Pain intensity and distress score were recorded until opioid doses were stable. In all, 37 patients were exami…

NarcoticsPalliative careReceptors Opioid muPainSettore MED/41 - AnestesiologiaOpioidPhenolsNeoplasmsReceptorsmedicineHumansIn patientProspective StudiesCancer painProspective cohort studyConversion ratioAnalgesicsMorphinebusiness.industryMedicine (all)Palliative CareCancerGeneral MedicineTapentadolmedicine.diseaseAnalgesics OpioidTapentadolOpioidmuDelayed-Action PreparationsAnesthesiaCancer pain; Conversion ratio; Opioid switching; Tapentadol; Analgesics Opioid; Delayed-Action Preparations; Humans; Morphine; Narcotics; Neoplasms; Pain; Palliative Care; Phenols; Prospective Studies; Receptors Opioid mu; Medicine (all)Opioid switchingExtended releasebusinessCancer painCancer pain Conversion ratio Opioid switching Tapentadol Analgesiamedicine.drugCurrent Medical Research and Opinion
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Half-sandwich molybdenum(III) compounds containing diazadiene ligands and their use in the controlled radical polymerization of styrene

2002

Abstract The reaction of CpMoCl2 with diazadiene ligands RNCHCHNR (R2dad) affords the corresponding paramagnetic complexes CpMoCl2(R2dad) (R=Ph, 1; p-Tol, 2; C6H3Pr2i-2,6, 3; and Pri, 4). All compounds have been characterized by EPR spectroscopy and have been investigated by cyclic voltammetry. They display one-electron oxidation and reduction processes, these being reversible or irreversible depending on the nature of R. The irreversibility of the reduction wave is due to a chemical follow-up process which consists of chloride loss from the reduced product. This phenomenon is suppressed in the presence of excess chloride in solution. An X-ray structure of 3 verifies the mononuclear na…

Nitroxide mediated radical polymerizationRadical polymerization010402 general chemistryPhotochemistry01 natural sciencesBiochemistryChlorideStyreneInorganic ChemistryLiving free-radical polymerizationchemistry.chemical_compoundCyclopentadienyl complexPolymer chemistryMaterials Chemistrymedicine[CHIM.COOR]Chemical Sciences/Coordination chemistryCyclopentadienylPhysical and Theoretical ChemistryControlled radical polymerizationMolybdenumDiazadiene ligands010405 organic chemistryChemistryOrganic Chemistry[CHIM.CATA]Chemical Sciences/Catalysis0104 chemical sciences[CHIM.POLY]Chemical Sciences/PolymersCobalt-mediated radical polymerizationPolymerizationParamagnetic organometallicsmedicine.drugJournal of Organometallic Chemistry
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Der austausch des cyclopentadienylliganden im methylcyclopentadienyl-mangantricarbonyl

1981

Abstract The exchange of the cyclopentadienyl ring in methylcyclopentadienylmanganese(I) tricarbonyl by methy-substituted benzenes in the presence of aluminium halide leads to [arene-Mn(CO) 3 ] + -ions. The reaction conditions have been optimised; in addition to the yield the purity of the complexes has been determined in some detail. After mild decomposition the arenes were analysed by GLC. Pure [arene-Mn(CO) 3 ] + -ions can be isolated with benzene, toluene, m - and o -xylene.

Organic ChemistryHalidechemistry.chemical_elementRing (chemistry)BiochemistryMedicinal chemistryDecompositionTolueneInorganic Chemistrychemistry.chemical_compoundCyclopentadienyl complexchemistryAluminiumYield (chemistry)Materials ChemistryOrganic chemistryPhysical and Theoretical ChemistryBenzeneJournal of Organometallic Chemistry
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From Pentalene to Dicyclopenta[b,g]naphthalene, or the Change towards Delocalized Structures

2005

Lining triples-corrected coupled-cluster methods as well as other high-level theoretical approximations, the optimized parameters and isomerization barriers of the family of compounds cyclopentadiene-(benzene) x -cyclopentadiene (x 0, 1, 2) are computed. In contrast to previous studies, s-indacene presents a localized C 2 h geometry. Also, the localized structure of pentalene is found to be the most stable, but when two benzene rings are intercalated between the five-member rings of pentalene, the resulting molecule preferably adopts a delocalized D 2 h conformation.

PentaleneCyclopentadieneChemistryAromaticityElectronic structureAtomic and Molecular Physics and OpticsCrystallographyDelocalized electronchemistry.chemical_compoundComputational chemistryAb initio quantum chemistry methodsMoleculePhysical and Theoretical ChemistryIsomerizationpentalene; dicyclopenta[b; g]naphthaleneChemPhysChem
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Understanding the mechanism of non-polar diels-alder reactions. A comparative elf analysis of concerted and stepwise diradical mechanisms

2010

The electron-reorganization along the concerted and stepwise pathways associated with the non-polar Diels-Alder reaction between cyclopentadiene (Cp, 1) and ethylene (2) has been studied using the topological analysis of the electron localization function (ELF) at the B3LYP/6-31G(d) level of theory. ELF results for the concerted mechanism stresses that the electron-reorganization demanded on the diene and ethylene reagents to reach two pseudo-diradical structures is responsible for the high activation energy. A comparative ELF analysis of some relevant points of the non-polar Diels-Alder reaction between Cp and styrene (10) suggests that these concerted mechanisms do not have a pericyclic e…

Pericyclic reactionEthyleneCyclopentadieneDieneDiradicalConcerted reactionStereochemistryOrganic Chemistryrespiratory systemBiochemistryElectron localization functionStyrenechemistry.chemical_compoundchemistryPhysical and Theoretical Chemistry
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Origin of the synchronicity in bond formation in polar Diels-Alder reactions: an ELF analysis of the reaction between cyclopentadiene and tetracyanoe…

2012

[EN] The origin of the synchronicity in C-C bond formation in polar Diels-Alder (P-DA) reactions involving symmetrically substituted electrophilic ethylenes has been studied by an ELF analysis of the electron reorganization along the P-DA reaction of cyclopentadiene (Cp) 4 with tetracyanoethylene (TCE) 10 at the B3LYP/6-31G* level. The present study makes it possible to establish that the synchronicity in C-C bond formation in P-DA reactions is controlled by the symmetric distribution of the electron-density excess reached in the electrophile through the charge transfer process, which can be anticipated by an analysis of the spin electron-density at the corresponding radical anion. The ELF …

Pericyclic reactionEthyleneCyclopentadieneINGENIERIA MECANICAOrganic ChemistryElectronTetracyanoethylenePhotochemistryBiochemistryIonchemistry.chemical_compoundchemistryElectrophilePolarPhysical and Theoretical Chemistry
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Preparation and Structure of Diexo-Oxanorbornane-fused 1,3-Heterocycles

2004

Via the reaction of diexo-oxanorbornanedicarboxylic anhydride with toluene, the diexo-aroylcarboxylic acid (3a) was prepared, which exists partly as the tautomeric lactol (3b). With bifunctional reagents, 3a yields fused heterocycles containing three-six rings. Thus, alkylenediamines result in imidazole- and 1,3-diazepine-fused oxygen- bridged isoindolones (6a,b), alkanolamines form the oxazole- and 1,3-oxazine-fused oxanorbornene derivatives (7a-c), and o-phenylenediamine undergoes cyclization to furnish the condensed benzimidazole (8). The reaction of 3a with diexo- aminonorbornanecarbohydrazide yields a pyrimidopyridazine containing six condensed rings (9). In a similar reaction with die…

PharmacologyCyclopentadieneLactolArylOrganic ChemistrySubstituentRetro-Diels–Alder reactionMedicinal chemistryTautomerAnalytical Chemistrychemistry.chemical_compoundchemistryInstitut für ChemieOrganic chemistryImidazoleOxazoleHETEROCYCLES
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Optically active titanium complexes containing a tridentate linked amido-cyclopentadienyl ligand

2000

Optically active titanium complexes Ti{η5:η1-C5R4SiMe2NC6H10 (OCH2Ph)-2}Cl2 (R = H, Me), containing a cyclopentadienyl ligand linked to the chiral trans-2-benzyloxycyclohexylamido group, were synthesized and characterized in both enantiomerically pure forms. A single crystal X-ray structure analysis of (−)-(R,R)-Ti{η5:η1-C5H4SiMe2NC6H10(OCH2Ph)-2}Cl2 shows a structure in which the benzyloxy group in the amido sidechain is not interacting with the titanium center. Upon activation with n-butyllithium, these complexes hydrogenate acetophenone N-benzylimine with low enantioselectivity. Chirality 12:472–475, 2000. © 2000 Wiley-Liss, Inc.

PharmacologyLigandOrganic ChemistryCenter (category theory)chemistry.chemical_elementOptically activeCatalysisAnalytical Chemistrychemistry.chemical_compoundCrystallographychemistryCyclopentadienyl complexDrug DiscoveryOrganic chemistryChirality (chemistry)Single crystalSpectroscopyAcetophenoneTitaniumChirality
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