Search results for "PG"

The Sinemurian ammonites of the Lusitanian Basin (Portugal): an example of complex endemic evolution.

2010

29 pages; International audience; This work synthesizes all of the observations since the late nineteenth century of the highly endemic Late Sinemurian (Obtusum Chronozone) ammonite faunas of the Lusitanian Basin. It is based mainly on recent abundant collections from the Penedo da Saudade section near São Pedro de Muel (Leiria, Portugal). This rich material (some eight species and four genera), collected bed by bed, allows us to propose an initial biostratigraphic, palaeobiogeographic, evolutionary and taxonomic synthesis of these mostly endemic faunas. The genus Epophioceroides n. gen. is new and three new species are identifi ed: Epophioceroides apertus n. gen. n. sp., Ptycharietites (Su…

EFFECT OF EXTRACTS FROM LEAVES AND RHIZOMES OF THE SEAGRASS POSIDONIA OCEANICA ON HEPG2 HEPATOCARCINOMA (HCC) CELLS

2022

Empirical and theoretical study of atelostomate (Echinoidea, Echinodermata) plate architecture: using graph analysis to reveal structural constraints.

2015

AbstractDescribing patterns of connectivity among organs is essential for identifying anatomical homologies among taxa. It is also critical for revealing morphogenetic processes and the associated constraints that control the morphological diversification of clades. This is particularly relevant for studies of organisms with skeletons made of discrete elements such as arthropods, vertebrates, and echinoderms. Nonetheless, relatively few studies devoted to morphological disparity have considered connectivity patterns as a level of morphological organization or developed comparative frameworks with proper tools. Here, we analyze connectivity patterns among apical plates in Atelostomata, the m…

Ramadan During Pregnancy – Fasting, Nutrition, Sleep Patterns and Offspring Health at Birth: A Cross-Sectional Study

2020

Background: Intrauterine exposure to Ramadan is associated with adverse offspring health outcomes. Yet, the dynamics behind these associations remain largely unexplored. We investigate if maternal intermittent fasting or other lifestyle changes during Ramadan affect birth outcomes, and determine whether nutritional and sleep behavior during non-fasting hours influences the fasting-birth weight association. Methods: Linear regressions are estimated using OLS to identify the associations between fasting, sleep behavior, sweets consumption and birth weight, 5-minute APGAR score and gestational age. Interaction terms between fasting and other behaviors are included to explore the potential mode…

Designing an Online Dungeons & Dragons Experience for Primary School Children

2020

In this work, we present the results of a role-playing game experience carried out with a group of 9- to 12-year-old children during the COVID-19 emergence. The ‘harmony in education’ approach has been used to adapt the game design to the constraints imposed by the online context and the young age of the students involved. The results show the effectiveness of the approach in terms of 21st-century skills training with particular evidence on perspective-taking.

Germline correction of an epimutation related to Silver-Russell syndrome.

2015

Like genetic mutations, DNA methylation anomalies or epimutations can disrupt gene expression and lead to human diseases. However, unlike genetic mutations, epimutations can in theory be reverted through developmental epigenetic reprograming, which should limit their transmission across generations. Following the request for a parental project of a patient diagnosed with Silver-Russell syndrome (SRS), and the availability of both somatic and spermatozoa DNA from the proband and his father, we had the exceptional opportunity to evaluate the question of inheritance of an epimutation. We provide here for the first time evidence for efficient reversion of a constitutive epimutation in the sperm…

The production of 85 kDa N-terminal fragment of apolipoprotein B in mutant HepG2 cells generated by targeted modification of apoB gene occurs by ALLN…

2010

Abstract To study the mechanism of low levels of full length and truncated apoB in individuals heterozygous for apoB truncation, a non-sense mutation was introduced in one of the three alleles of apob gene of HepG2 cells by homologous recombination. Despite very low levels of apoB-82 (1–2%) in the media, a prominent N-terminal apoB protein of 85 kDa (apoB-15) was secreted that fractionated at d > 1.065 in density gradient ultracentrifugation. The mechanism of production of this short protein was studied by 35S-methionine pulse–chase experiment. Oleate prevented presecretory degradation of apoB-100 in the cell and resulted in increased secretion of newly synthesized apoB-100 with decreases i…

Backoff Hardware Architecture for Inter-FPGA Traffic Management

2017

International audience; Multi-FPGA platforms are considered to be the mostappropriate experimental way to emulate a large Multi-ProcessorSystem-on-Chip based on a Network-on-Chip. However, theuse of a Network-on-Chip in several FPGAs requires inter-FPGA communication links to replace intra-FPGA links betweenrouters. As the ratio of the logic capacity to the number of IOsonly increases slowly with each generation of FPGA, IOs inFPGA are becoming a scare resource. And as there are morerouters than IOs, using a Network-on-Chip requires sharinginter-FPGA links between routers, and sharing an external linkcan lead to bottlenecks. Here, we evaluate the inter-FPGA trafficmanagement using a backoff…

Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products.

2010

Cigarette smoke is the main cause of chronic obstructive pulmonary disease (COPD), where it can contribute to the observed airway inflammation. PGE(2) is produced within human airways, and both pro- and anti-inflammatory activities have been reported. We quantitated PGE(2) concentrations in induced sputum supernatants from different groups of subjects and correlated the obtained values to neutrophil infiltration as well as to the expression of cyclooxygenase-2 (COX-2). Cigarette smoke extract (CSE) was used to evaluate the effect of smoking on COX-2 and PGE(2) receptor expression as well as on PGE(2) release in neutrophils and alveolar macrophages (AM) obtained from normal donors. The effec…

Pārtikas preču piegādes uzņēmumu apgrozījuma izmaiņas

2021

Bakalaura darba temats ir “Pārtikas preču piegādes uzņēmumu apgrozījuma izmaiņas”. Bakalaura darba mērķis ir izpētīt tirgus formas un e-komercijas teorētiskos aspektus, izprast tās darbības iespējas nākotnē un veikt pārtikas preču piegādes apgrozījuma dinamikas analīzi, kā rezultātā, sniegt priekšlikumus pārtikas preču piegādes uzņēmumu apgrozījuma palielināšanai. Darbā tiek raksturoti tirgus konkurences tipi, peļņas un apgrozījuma rādītāji, patērētāju uzvedības izmaiņu iemesli, saistība ar pieprasījumu, arī tiek apskatīts elektroniskās komercijas jēdziens. Darbā tiek analizēti statistiskie dati saistībā ar e-komerciju pasaulē un Latvijā, uzmanība tiek pievērsta tieši tiešsaistes pārtikas p…