Search results for "PHARMACOLOGY"
showing 10 items of 8885 documents
Kiusaamiskokemukset yhteisöön kiinnittymisen esteenä
2009
Artikkeli perustuu Puheviestinnän päivillä 25.9.2009 pidettyyn plenum-esitelmään Kiusaamiskokemukset yhteisöön kiinnittymisen esteenä.
3-NPA induziert Ischämietoleranz der Rattenleber nach warmer Ischämie
2005
Until now little is known about the potential of 3-nitroproprionic acid (3-NPA) to reduce ischemia/ reperfusion injury (IRI) of the rat liver in vivo.
Sulfonamide moiety as "molecular chimera" in the design of new drugs.
2021
Background: The -SO2NH- group is of great significance in modern pharmaceutical use since, in sulfa-drugs, it is possible to introduce easily chemical modifications, and even small changes may lead to an improved version of an already existing drug. Objective: This paper aims to describe updated information in the sulfonamide field with a particular focus on new mechanisms of action, especially if discovered by employing computational approaches. Methods: Research articles that focused on the use of the sulfonamide moiety for the design, synthesis, and in vitro/in vivo tests of various diseases were collected from various search engines like PubMed, Science Direct, Google Scholar, and Scop…
Biodegradable Ultrasmall-in-Nano Gold Architectures: Mid-Period In Vivo Distribution and Excretion Assessment
2018
Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo[ b ]thiophene derivatives
2014
A new series of 3-benzoylamino-5-imidazol-5-yl-benzo[b]thiophenes and the parent amino derivatives were synthesized and screened as antitumor agents. All tested compounds showed concentration-dependent antiproliferative activity profile against HeLa cell line, exhibiting GI50 values in the low micromolar range. The most active compounds were tested in cell cycle perturbation experiments. A rapid accumulation of cells in the G2/M phase, with a concomitant reduction of cells in both the S and G0/G1 phases, was observed, suggesting that cell exposure to selected derivatives produces mitotic failure. To rationalize the biological results, the 3-benzoylamino-benzo[b]thiophenes were analyzed thro…
Vuorovaikutuksen jännitteet toimittajan työssä: Sovittelujournalismin herättämiä näkökulmia
2018
Vuorovaikutus on läsnä toimittajien työssä monella tavalla. Suhde yleisöön on keskeinen toimittajan työtä määrittävä motivaatio ja työn kohde, ja suuri osa tiedonhankinnasta tapahtuu vuorovaikutuksessa lähteiden kanssa. Lisäksi toimitustyötä tehdään yhä enemmän erilaisissa ammatillisissa tiimeissä ja verkostoissa. Vaikka toimittajan työtä ja itseymmärrystä on tutkittu monesta näkökulmasta, vuorovaikutuksen tarkastelu on jäänyt vähäiseksi. Tässä artikkelissa analysoidaan, miten toimittajat kuvaavat työhönsä kuuluvaa vuorovaikutusta ja siihen sisältyviä jännitteitä. Tutkimusaineistona on Sovittelujournalismi-toimintatutkimushankkeen viidessä työpajaryhmässä eli yhteensä 14 työpajatapaamisessa…
Le médicament homéopathique dans l'histoire du médicament, Co construction, confrontation, coopération. Histoire, Transmission, Représentation
2007
The dynamics of this thesis resides in the search for the breach between the historical positioning (in relation to scientific fact itself) of homeopathic medication in the history of medical sciences, and the representation made of it in the past and present. By distinguishing what may be at stake, we are led to identify the positioning and impact of the mode of transmitting scientific fact as lacking a historical link to the history of medical sciences, notably medication. Our research hypothesis thus postulates that the transmission mode is at the source of discrepancies in representation. The links between context breakthroughs, such as the role of influences, are just parameters that, …
Double copies of blaKPC-3::Tn4401a on an IncX3 plasmid in Klebsiella pneumoniae successful clone ST512 from Italy
2015
ABSTRACT A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla KPC genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla KPC-3 gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla KPC-3 ::Tn 4401a caused by intramolecular transposition events were detected in the plasmid.
A Novel Pathophysiological Mechanism Contributing to Trigeminal Neuralgia
2016
Trigeminal neuralgia (TN) is a form of neuropathic pain that affects the fifth cranial nerve, the most widely distributed nerve in the head. Although TN has been associated with a variety of pathological conditions, neurovascular compression on the trigeminal nerve, as it exits the brain stem, is the most frequent reported cause. This compression provides a progressive demyelination of the nerve and a subsequent aberrant neural transmission. Although several studies have clarified some physiopathological mechanisms underlying TN, the molecular basis remains vague. Very recently the substitution of methionine 136 by valine (MET126Val) in sodium channel Nav1.6 in a case study of typical TN ha…
Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action
2015
Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most potent, with an IC50 value of 16.4 nm and kinact/Ki=1.6×106 m−1 s−1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations. Inhibition…