Search results for "PLE"
showing 10 items of 22773 documents
Performance and Specificity of 6 Immunoassays for TSH Receptor Antibodies: A Multicenter Study
2017
Background: The measurement of TSH receptor (TSHR) antibodies is warranted for diagnosis of Graves’ disease (GD). Objective: The performance, detection sensitivity, and specificity of 6 TSHR immunoassays were compared. Methods: Two bioassays and 4 binding assays (Kronus, Immulite, Kryptor, Dynex) were compared in a dilution study performed in patients with autoimmune thyroid disease. Both bioassays were compared to 2 binding assays using stimulatory (M22) and blocking (K1–70) monoclonal antibody (MAb) mixtures. Results: Thirty samples from stimulatory (TSAb)-positive/blocking (TBAb)-negative patients with GD were diluted serially and measured in all assays. Samples were positive until dilut…
The Impact of Epigallocatechin Gallate and Coconut Oil Treatment on Cortisol Activity and Depression in Multiple Sclerosis Patients
2021
(1) Background: Multiple sclerosis (MS) is pathogenically characterized by high oxidative stress and symptomatically by progressive muscle loss and increased body fat associated with the presence of depression. Epigallocatechin gallate (EGCG) (particularly present in green tea) and ketone bodies (in particular beta-hydroxybutyrate (BHB)), whose main source is coconut oil, have shown emotional benefits and body fat loss. The aim of this study was to assess the impact of EGCG and coconut oil on cortisol activity related to fat loss and depression in MS patients. (2) Methods: The study involved 51 MS patients who were randomly divided into an intervention group or a control group. The interven…
Postoperative Lens Position Preoperatively Determined by Scheimpflug Photography
1999
The position of the artificial lens has an important influence on refractive power calculation. We compared the position of the crystalline lens with that of the artificial lens after cataract surgery by means of Scheimpflug photography. A difference in position of approximately 0.8 mm in the anterior direction could be determined.
Objective assessment of cataract: Comparison between the Lens Opacities Classification System III and a Scheimpflug camera
2015
Purpose Develop an automatic system for cataract classification using the Sirius Scheimpflug for both nuclear and cortical cataract. Methods Scheimpflug images were taken using the Sirius system in 50 patients with nuclear and/or cortical cataract (mean age 69 ± 9.2 years). The nuclear opacity (NO) and cortical opacity was graded by an ophthalmologist according to the Lens Opacities Classification System (LOCSIII) by comparing the slit-lamp image with the LOCS's standard nuclear images. A custom-made MATLAB program was used to calculate the pixel intensity value within a region of interest (ROI) of the nucleus and to calculate the percentage of opaque pixels in the cortex. Results Eighty-ni…
Effect of Phenylephrine on the Accommodative System
2016
Accommodation is controlled by the action of the ciliary muscle and mediated primarily by parasympathetic input through postganglionic fibers that originate from neurons in the ciliary and pterygopalatine ganglia. During accommodation the pupil constricts to increase the depth of focus of the eye and improve retinal image quality. Researchers have traditionally faced the challenge of measuring the accommodative properties of the eye through a small pupil and thus have relied on pharmacological agents to dilate the pupil. Achieving pupil dilation (mydriasis) without affecting the accommodative ability of the eye (cycloplegia) could be useful in many clinical and research contexts. Phenylephr…
Slowed abduction saccades in bilateral internuclear ophthalmoplegia
1992
Horizontal eye movements were investigated in 65 patients with bilateral internuclear ophthalmoplegia utilizing direct current electro-oculography. Abduction saccades were slowed in 35 patients (53.8%), being hypermetric in 65.7% of them. Slowing of abduction saccades is attributed to impaired inhibition of the tonic resting activity of the antagonistic medial rectus muscle. Experimental data indicate that this slowing results from a lesion of an uncrossed connection between the pontine reticular formation and the oculomotor nucleus. The prevalence of hypermetric abduction saccades increased with increasing severity of adduction paresis on the opposite eye. This confirms the view that media…
Macula structural and vascular differences in glaucoma eyes with and without high axial myopia
2021
AbstractAimsTo assess the thickness of various retinal layers, and the superficial vessel density (sVD) in the macula of glaucomatous eyes and their associations with axial length (AL) and visual field mean deviation (VFMD) to identify parameters useful for glaucoma management in myopic eyes.Methods248 glaucoma patients (401 eyes) participating in the Diagnostic Innovations in Glaucoma Study observational cohort representing 3 axial myopia groups (non-myopia: n=146 eyes; mild myopia: n=208 eyes; high myopia (AL>26 mm): n=47 eyes) who completed macular OCT and OCT-Angiography imaging were included. The cross-sectional associations of AL and VFMD with the thickness of the ganglion cell inn…
Abduction saccades in unilateral internuclear ophthalmoplegia
1990
Horizontal eye movements were investigated in 60 consecutive patients with unilateral internuclear ophthalmoplegia utilizing direct current electrooculography. In nine patients additional conjugated slowing of ipsiversive saccades indicated the diagnosis of a one-and-a-half syndrome. Slowing of abduction saccades was bilateral in two patients and unilateral in 20 (ipsilateral to the MLF lesion in 17 patients and contralateral in three). Slowing of abduction saccades was attributed to impaired inhibition of the tonic resting activity of the antagonistic medial rectus muscle. On the eye contralateral to the lesion 70% of the patients had abduction nystagmus and 66.7% hy permetric abduction sa…
CT and MR Imaging of Orbital Lesions
1989
In the past, the diagnosis of orbital lesions manifested clinically by unilateral or bilateral proptosis and/or impaired ocular motility has relied on conventional skull films and orbital radiographs, sonography, fluorescein angiography, internal and external carotid angiography, and ophthalmic venography. The introduction of CT, however, has greatly reduced the importance of invasive diagnostic procedures (Wende et al. 1977).
Binocular Vision in Patients with Multiple Sclerosis.
2021
Amparo Gil-Casas,1,2 David P Piñero-Llorens,2 Ainhoa Molina-Martin2 1Clínica Optométrica, Fundació Lluís Alcanyís, University of Valencia, Valencia, Spain; 2Optics and Visual Perception Group (GOPV), Department of Optics, Pharmacology, and Anatomy, University of Alicante, Alicante, SpainCorrespondence: Ainhoa Molina-MartinDepartment of Optics, Pharmacology, and Anatomy, University of Alicante, Carretera San Vicente del Raspeig, San Vicente del Raspeig, 03690, Alicante, SpainTel +34 965 903-400Email ainhoa.molina@ua.esPurpose: Oculomotor disorders have been reported in multiple sclerosis (MS) in up to 80% of cases. There have …