Search results for "PROTECTION"
showing 10 items of 1623 documents
Side-specific effects by cadmium exposure: Apical and basolateral treatment in a coculture model of the blood–air barrier
2010
Cadmium (Cd{sup 2+}) is a widespread environmental pollutant, which is associated with a wide variety of cytotoxic and metabolic effects. Recent studies showed that intoxication with the heavy metal most importantly targets the integrity of the epithelial barrier. In our study, the lung epithelial cell line, NCI H441, was cultured with the endothelial cell line, ISO-HAS-1, as a bilayer on a 24-well HTS-Transwell (registered) filter plate. This coculture model was exposed to various concentrations of CdCl{sub 2}. The transepithelial electrical resistance decreased on the apical side only after treatment with high Cd{sup 2+} concentrations after 48 h. By contrast, a breakdown of TER to less t…
''Deferoxamine blocks death induced by glutathione depletion in PC 12 cells''
2013
Chouraqui, E. | Leon, A. | Repesse, Y. | Prigent-Tessier, A. | Bouhallab, S. | Bougle, D. | Marie, C. | Duval, D.; International audience; ''The purpose of the present work was to investigate the mechanisms by which glutathione depletion induced by treatment with buthionine sulfoximine (BSO) led within 24-30 h to PC 12 cells apoptosis. Our results showed that treatment by relatively low concentrations (10-30 mu M) of deferoxamine (DFx), a natural iron-specific chelator, almost completely shielded the cells from BSO-induced toxicity and that DFx still remained protective when added up to 9-12 h after BSO treatment. On the other hand, phosphopeptides derived from milk casein and known to carr…
The role of mitochondrial transition pore, and its modulation, in traumatic brain injury and delayed neurodegeneration after TBI
2009
Following severe traumatic brain injury (TBI), a complex interplay of pathomechanism, such as exitotoxicity, oxidative stress, inflammatory events, and mitochondrial dysfunction occurs. This leads to a cascade of neuronal and axonal pathologies, which ultimately lead to axonal failure, neuronal energy metabolic failure, and neuronal death, which in turn determine patient outcome. For mild and moderate TBI, the pathomechanism is similar but much less frequent and ischemic cell death is unusual, except with mass lesions. Involvement of mitochondria in acute post-traumatic neurodegeneration has been extensively studied during the last decade, and there are a number of investigations implicatin…
Effect of environmental conditions on the durability of polycarbonate for the protection of cultural heritage sites.
2019
Polycarbonate is a good material for covering and protecting cultural heritage sites because of its durability, mechanical properties, and transparency. However, polycarbonate degrades under environmental weathering with a significant decrease of physical and mechanical properties and loss of transparency. In this work, the contemporary presence of ultraviolet irradiation and different temperature and moisture conditions have been taken into account to study the environmental degradation of this polymer with regard to its mechanical and optical properties. The photo-oxidation reactions cause a decrease in the molecular weight and the formation of many oxygenated species. The hydrolytic sci…
Cavitation corrosion and repassivation kinetics of titanium in a heavy brine LiBr solution evaluated by using electrochemical techniques and Confocal…
2011
The cavitation corrosion behaviour of commercially pure Grade 2 titanium in a 992 g/l LiBr solution has been investigated at 25 °C using an ultrasound device. Cavitation was found to have more influence on the anodic branch than on the cathodic branch, shifting the corrosion potential, Ecorr, and the OCP value towards more negative potentials, and increasing the corrosion current density, icorr, by six times. The repassivation kinetics of Grade 2 titanium have also been studied in the 992 g/l LiBr solution, at 25 °C and various applied potentials, using cavitation to damage the electrode surface. The repassivation kinetics have been analysed in terms of the current density flowing from the …
Luovat ja taidelähtöiset menetelmät lastenkodin arjessa : ohjaajan ja lapsen vuorovaikutustapojen rikastaminen
2016
Tämän tutkielman tarkoituksena on edesauttaa vuorovaikutusta rikastavien, luovien ja taidelähtöisten menetelmien käyttöä lastensuojelun sijaishuollossa, jossa tehdään monipuolisia kohtaamisen tapoja edellyttävää ihmissuhdetyötä. Tutkimuksen viitekehys rakentuu sosiaalisia piirteitä korostavista taiteen kehityssuunnista. Tutkimuksessa käsitellään muun muassa dialogisen taiteen teoriaa sekä taidelähtöiseen toimintaan liittyvää esteettistä etääntymistä ja mahdollisuuksille avointa tilaa. Tutkimus on lähtökohdiltaan laadullinen tutkimus, jonka ihmis- ja tiedonkäsitys perustuu fenomenologis-hermeneuttiseen perinteeseen. Tutkimusstrategiana on toimintatutkimus, jossa tutkimuksen osat ovat muotout…
Conceptual Design and Modeling of Fast Discharge Unit for Quench Protection of Superconducting Toroidal Field Magnets of DTT
2020
The paper deals with the modelling and simulation of a Fast Discharge Unit (FDU) for quench protection of the Toroidal Field (TF) magnets of the Divertor Tokamak Test, an experimental facility under design and construction in Frascati (Italy). The FDU is a safety key component that protects the superconducting magnets when a quench is detected through the fast extraction of the energy stored in superconducting magnets by adding in the TF magnets a dump (or discharge) resistor. In the paper, two different configurations of dump resistors (fixed and variable respectively) have been analysed and discussed. As a first result, it is possible to underline that the configuration with variable dump…
Conceptual Design and Modeling of the Toroidal Field Coils Circuit of DTT
2020
Italian Divertor Tokamak Test (DTT) facility is part of the general European programme on the fusion research. Its specific role is to cover the gap on the power exhaust for the future DEMOstration power plant (DEMO). This tokamak will be built and installed in Italy at Frascati ENEA laboratories. The paper describes the Toroidal Field (TF) coils circuit powered by a TF power supply that feeds in series 18 toroidal superconducting magnets and the development of three software models in order to validate the adopted technical solutions in term of maximum voltage and maximum current stress on each power device/component, due to both the operating and fault conditions, and across TF coils.
Global health burden of PM2.5, black and organic carbon aerosols
2021
Cuando el exceso de protección se convierte en un problema: factores globales que inciden en el desarrollo de riesgos en los adolescentes
2014
El presente artículo, reflexiona en torno al hecho común y cada vez más representativo sobre cómo adolescentes, que proceden de entornos familiares socialmente ajustados y envueltos en garantías, acaban siendo protagonistas de prácticas de riesgo que derivan en su propio deterioro. Podemos afirmar, que los nuevos tiempos amparados en las garantías de la globalización, han logrado adiestrar a estos nuevos adolescentes acomodados, socializados en espacios de bienestar, preservados ante cualquier contingencia y vacunados contra las inercias de la exclusión. Como decimos, los adolescentes viven con mucha protección y muchas posibilidades, pero estas garantías no evitan los problemas. Así, algun…