Search results for "RESPIRATORY"

15. Mainzer Allergie-Workshop 2003

2003

L’échographie en réhabilitation, une émergence anglo-saxonne

2017

Resume L’echographie est un outil qui a vu le jour dans les annees 1950 en medecine, et depuis s’est considerablement developpe pour de nombreuses professions de sante dont les kinesitherapeutes. Son accessibilite, son absence d’effet secondaire et son faible cout en font un moyen d’evaluation indispensable pour les kinesitherapeutes explorant les alterations du mouvement et cherchant a ameliorer la pertinence du plan de traitement propose aux patients. De nombreux pays ont deja œuvre dans le sens de l’amelioration de la formation et de la pratique en echographie pour les kinesitherapeutes. L’integration du developpement de cet outil en France doit necessairement passer par des collaboratio…

Hereditäres Angioödem in einer Familie mit spezifischen Mutationen sowohl im Plasminogen‐ als auch im SERPING1‐Gen

2020

Food allergy and atopic dermatitis phenotypes according to molecular allergology: Lessons from cohort around the world

2020

International audience

N-terminal hevein-like domains (4.3 kDa) but not 31 kDa endochitinases are responsible for IgE-mediated in vitro and in vivo reactions in latex-fruit…

2005

The first wave of the Spanish COVID-19 epidemic was associated with early introductions and fast spread of a dominating genetic variant

2020

The COVID-19 pandemic has shaken the world since the beginning of 2020. Spain is among the European countries with the highest incidence of the disease during the first pandemic wave. We established a multidisciplinar consortium to monitor and study the evolution of the epidemic, with the aim of contributing to decision making and stopping rapid spreading across the country. We present the results for 2170 sequences from the first wave of the SARS-Cov-2 epidemic in Spain and representing 12% of diagnosed cases until 14th March. This effort allows us to document at least 500 initial introductions, between early February-March from multiple international sources. Importantly, we document the …

Emergence and spread of a SARS-CoV-2 variant through Europe in the summer of 2020.

2020

A variant of SARS-CoV-2 emerged in early summer 2020, presumably in Spain, and has since spread to multiple European countries. The variant was first observed in Spain in June and has been at frequencies above 40% since July. Outside of Spain, the frequency of this variant has increased from very low values prior to 15th July to 40-70% in Switzerland, Ireland, and the United Kingdom in September. It is also prevalent in Norway, Latvia, the Netherlands, and France. Little can be said about other European countries because few recent sequences are available. Sequences in this cluster (20A.EU1) differ from ancestral sequences at 6 or more positions, including the mutation A222V in the spike pr…

Latex allergy: the sum quantity of four major allergens shows the allergenic potential of medical gloves

2007

Background:  Assessment of allergenic potential of medical devices made of natural rubber latex (NRL) requires the measurement of concentrations of specific allergenic proteins or polypeptides eluting from rubber. Methods:  Four NRL allergens (Hev b 1, 3, 5, and 6.02) were quantified in all medical glove brands marketed in Finland in 1999, 2001, and 2003 (n = 208) by a capture enzyme immunoassay. The results were compared with those obtained from previous nationwide market surveys, using a skin prick test-validated human IgE-based ELISA-inhibition method. Results:  A high overall correlation (r = 0.87, 95% CI 0.83–0.90) emerged between the sum values of the four allergens(μg/g glove) and Ig…

High prevalence of SARS-CoV-2 antibodies in pets from COVID-19+ households

2020

AbstractIn a survey of household cats and dogs of laboratory-confirmed COVID-19 patients, we found a high seroprevalence of SARS-CoV-2 antibodies, ranging from 21% to 53%, depending on the positivity criteria chosen. Seropositivity was significantly greater among pets from COVID-19+ households compared to those with owners of unknown status. Our results highlight the potential role of pets in the spread of the epidemic.

Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs.

2021

Mitochondria contain a specific translation machinery for the synthesis of mitochondria-encoded respiratory chain components. Mitochondrial tRNAs (mt-tRNAs) are also generated from the mitochondrial DNA and, similar to their cytoplasmic counterparts, are post-transcriptionally modified. Here, we find that the RNA methyltransferase METTL8 is a mitochondrial protein that facilitates 3-methyl-cytidine (m3C) methylation at position C32 of the mt-tRNASer(UCN) and mt-tRNAThr. METTL8 knockout cells show a reduction in respiratory chain activity, whereas overexpression increases activity. In pancreatic cancer, METTL8 levels are high, which correlates with lower patient survival and an enhanced resp…