Search results for "RNA."
showing 10 items of 44327 documents
Clathrin- and Caveolin-Independent Entry of Human Papillomavirus Type 16—Involvement of Tetraspanin-Enriched Microdomains (TEMs)
2008
BACKGROUND: Infectious entry of human papillomaviruses into their host cells is an important step in the viral life cycle. For cell binding these viruses use proteoglycans as initial attachment sites. Subsequent transfer to a secondary receptor molecule seems to be involved in virus uptake. Depending on the papillomavirus subtype, it has been reported that entry occurs by clathrin- or caveolin-mediated mechanisms. Regarding human papillomavirus type 16 (HPV16), the primary etiologic agent for development of cervical cancer, clathrin-mediated endocytosis was described as infectious entry pathway. METHODOLOGY/PRINCIPAL FINDINGS: Using immunofluorescence and infection studies we show in contra…
Tumor targeting of baculovirus displaying a lymphatic homing peptide.
2008
Background Tumor-associated cells and vasculature express attractive molecular markers for site-specific vector targeting. To attain tumor-selective tropism, we recently developed a baculovirus vector displaying the lymphatic homing peptide LyP-1, originally identified by ex vivo/in vivo screening of phage display libraries, on the viral envelope by fusion to the transmembrane anchor of vesicular stomatitis virus G-protein. Methods In the present study, we explored the specificity and kinetics of viral binding and internalization as well as in vivo tumor homing of the LyP-1 displaying virus to elucidate the applicability of baculovirus for targeted therapies. Results We demonstrated that th…
Discipline del Design e “Slow Journalism”: un antidoto alle fake-news
2021
L’articolo sviluppa una riflessione a partire da un’esperienza di ricerca maturata all’interno dell’Università degli Studi di Palermo nell’ambito del progetto PO FERS “Fake News” che aveva come obiettivo quello di elaborare nuovi e più efficaci meccanismi automatici di valutazione dell’autenticità, originalità e rilevanza dell’informazione prodotta dal giornalismo etico e partecipativo a partire da metodologie e strumenti progettuali propri del design della comunicazione e dell’informazione. The article develops a reflection on a research experience gained within the University of Palermo in the context of the PO FERS “Fake News” project, which aimed to develop new and more effective automa…
The mechanism of retro-cue effect in visual working memory : Cognitive phase separation
2020
Retro-cue effect (RCE) refers to the phenomenon that individuals can use retro-cues to improve their visual working memory (VWM) performance of target items after memory stimuli disappear. To explain the mechanism of RCE in VWM, five different hypotheses have been proposed by previous studies: the hypothesis of enhancing target representations, the hypothesis of forgetting non-target representations, the hypothesis of preventing memory degradation, the hypothesis of preventing interference from probe array and the hypothesis of cognitive phase separation. Although RCE has been repeatedly observed in previous studies, the mechanism of RCE remains unclear. In this study, we conducted three ex…
视觉工作记忆中回溯线索效应的影响因素 [The Influencing Factors of Retro-Cue Effect in Visual Working Memory]
2022
The visual working memory is a temporary storage system, which encodes, maintains and retrieves visual information. The researchers have found that adding retro-cues to the maintenance phase of memory leads to changes in participants’ memory performance, which is the retro-cue effect. The magnitude of the retro-cue effect is not set in stone, but changes with the changes of its influencing factors. However, there is no study to summarize the influencing factors of the retro-clue effect. This paper looked into the articles related to the study of the retro-cue effect and summarized the influencing factors of the retro-cue effect: memory items, maintenance interval time, interference in maint…
Procedures for study of teaching practices. Literature Review
2012
Interest in studying teaching practices has increased, because of the need to evaluate teachers and dissatisfaction with the usual ways of doing it. Recent approaches with Value-Added Models, based on students’ results on achievement tests do not seem satisfactory. The article is based on a review of literature and classifies the approaches to practices in three groups: instruments based on information given by teachers; observation protocols; and approaches based on the analysis of products of the practices. Specific tools are described and advantages and disadvantages of the three approaches are discussed. El interés por las prácticas docentes ha aumentado, en parte por la necesidad de ev…
Journalistien suhtautuminen Suomen Punaisen Ristin Veripalveluun
2004
Le lave. Gli usi ornamentali nell'architettura storica in Sicilia
2012
L’attività vulcanica in Sicilia e nelle isole limitrofe ha nel corso dei millenni contribuito a modellare l’aspetto fisico di un vasto comprensorio, generando sconfinati giacimenti naturali di materiale lapideo impiegato fin dall’età antica nell’attività edificatoria. Relativamente all’utilizzo in architettura, va sottolineata l’ambivalenza di questo materiale chiamato nei secoli a svolgere tanto la funzione di pietra da costruzione, quanto quella di pietra ornamentale. Catania e l’intera area etnea, ma anche l’isola di Lipari, conservano le testimonianze più consistenti e significative di un ricorso ab antiquo alla pietra lavica e ai suoi derivati in architettura. Da una ricognizione compl…
L'utilisation de la pierre ponce volcanique dans la construction de voûtes en Sicile au début de l’âge moderne
2016
La stereotomia della pietra applicata alla costruzione di volte ha in Sicilia una lunga tradizione, documentata a partire dal tempo della dominazione normanna nell’isola (XI-XII secolo). Tale pratica costruttiva prosegue nei secoli successivi, con momenti di apice nella qualità del taglio stereotomico nelle architetture federiciane (prima metà del XIII secolo), un successivo scadimento nel corso del XIV secolo, e il ritorno a una fertile stagione di sperimentazione a partire dal Quattrocento, sotto l’impulso impresso al cantiere locale dall’arrivo di modelli e maestri dalla penisola iberica (soprattutto da Barcellona, Valencia e Palma di Maiorca). Questa lunga tradizione prosegue ancora nel…
Análisis sociojurídico de las transformaciones en la provisión de seguridad. Austeridad y aporofobia como racionalidades estructurantes de los derech…
2021
Desde la perspectiva sociojurídica de los estudios de la gobernabilidad, se analiza la evolución de las estrategias de provisión de seguridad, desde su orientación neoliberal hasta el predominio de la austeridad desde la crisis de 2008. Se delimita así un escenario en el que la desigualdad y la aporofobia son elementos fundamentales del marco axiológico hegemónico. Esto es relevante para la configuración y efectividad de los derechos sociales de distintos grupos vulnerables. El artículo se aproxima finalmente a la situación de las empleadas de hogar y de quienes acceden a una vivienda mediante la ocupación de inmuebles vacíos en España.