Search results for "SARS"
showing 10 items of 1372 documents
Transgresywny charakter pisarstwa w polu teorii polityki
2023
Tezą niniejszej artykułu jest twierdzenie, iż specyficzną cechą pisarstwa w dziedzinie teorii polityki jest jego trangresywność, a więc przekraczanie niektórych norm. Oznacza to, że podejmuje ono polemikę z wzorcem naukowości, który wyraża się w formalnych regułach, stanowiących aktualne kryterium naukowości. Obranie perspektywy teorii polityki, inspirowanej dorobkiem Pierre’a Bourdieu, pokazuje, że przyjęta definicja nauki jest kluczową stawką w grze toczonej na polu nauki, w tym na „subpolu” teorii polityki. Celem artykułu jest pokazanie, iż transgresywny charakter piśmiennictwa teoriopolitycznego nie stawia go poza naukowością, lecz jest formą negocjacji samych norm naukowości poprzez pr…
"Missed" Information: A Moral Failing that Erodes Efforts to Tackle the COVID-19 Pandemic.
2021
Alterations in blood sera metabolome and blood transcriptome in hospitalized COVID-19 patients
2021
COVID-19 pandēmija turpina būt lielākais globālais drauds sabiedrības veselībai, sasniedzot ne tikai apjomīgus infekcijas gadījumu skaitus, bet arī salīdzinoši augstu mirstību starp tiem (~2%). COVID-19 raksturīga heterogēna slimības gaita un šobrīd nav atrasti medikamenti, kas novērš smaga un kritiska stāvokļa iestāšanos. Lai noskaidrotu kādi mehānismi iesaistīti stacionētu COVID-19 pacientu patoģenēzē, tika veikta mērķēta metaboloma un transkriptoma analīze divos laika punktos: pacientam iestājoties slimnīcā un aptuveni 30 dienas vēlāk, tādejādi salīdzinot akūtās fāzes paraugus pret atveseļošanās fāzi. Rezultāti liecina par spēcīgām izmaiņām vairākos metabolajos un imūnsistēmas signālceļo…
"Aby wszędzie być i wszystko widzieć". Doświadczanie miejsc i siebie w trakcie górskich podróży. Relacje Ślązaków
2015
“To be everywhere” and “see everything” is a declaration by Father Euzebiusz Franciszek Stateczny, a well-known Silesian writer from the turn of the 20th century, and an extraordinary monk and tenacious traveller, who in a true positivist fashion valued the truth about the world based on one’s own experience. By outlining a comprehensive need to get to know the world, Stateczny acted as a cosmographer, which prompted the author of the article to try to establish whether this declaration also applied to other travellers from the region and how this completeness was supposed to be expressed. The author’s overview of Silesian accounts of trips to the mountains (by Karol Miarka, Rev Antoni Stab…
La Corte eur. dir. uomo e la non discriminazione tra coppie etero e omoaffettive
2018
Il saggio analizza le ricadute sul dibattito in tema di diritti fondamentali della recente decisione della Corte di Strasburgo su un singolare caso di discriminazione in base all’orientamento sessuale per così dire "alla rovescia" , in quanto dovuta all’inaccessibilità alla coppie eterosessuali austriache all’istituto della Partnership registrata, riservato alle coppie same-sex. Esaminata la giurisprudenza della Corte europea dei diritti dell'uomo in tema di non discriminazione in base all'orientamento sessuale e la soluzione adottata nel caso in questione con l'attestarsi della maggioranza dei giudici sulla dottrina del “separate but equal”, l'indagine si volge poi a considerare le spinte …
More nature in the city
2020
According to projects and practices that the Italian botanists and ecologists are carrying out for bringing “more nature in the city”, new insights for a factual integration between ecological perspectives and more consolidated aesthetic and agronomic approaches to the sustainable planning and management of urban green areas are provided.
Microstructural evaluation and recommendations for face masks in community use to reduce the transmission of respiratory infectious diseases
2022
Funding Information: A.K., H.Y. and R.J. also acknowledges the funding through Academy of Finland BESIMAL (Decision No. 334197) and Aalto University, Department of Communications and Networking. This work has also received funding in part from the EPSRC UK (grant number EP/R012091/1). A.K. would also like to thank Mr. Volkan Kaplan for the fruitful discussions in the early concept generation. Publisher Copyright: © 2022 The Author(s) Background and Objective: Recommendations for the use of face masks to prevent and protect against the aerosols (≤5µm) and respiratory droplet particles (≥5µm), which can carry and transmit respiratory infections including severe acute respiratory syndrome coro…
IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection
2021
The renal involvement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported. The etiology of kidney injury appears to be tubular, mainly due to the expression of angiotensin-converting enzyme 2, the key joint receptor for SARS-CoV-2; however, cases with glomerular implication have also been documented. The multifactorial origin of this renal involvement could include virus-mediated injury, cytokine storm, angiotensin II pathway activation, complement dysregulation, hyper-coagulation, and microangiopathy. We present the renal histological findings from a patient who developed acute kidney injury and de novo nephrotic syndrome, highly suggestive of acute IgA-domina…
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…
Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations.
2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic represents the most severe global health crisis in modern human history. One of the major SARS-CoV-2 virulence factors is nonstructural protein 1 (Nsp1), which, outcompeting with the binding of host mRNA to the human ribosome, triggers a translation shutdown of the host immune system. Here, microsecond-long all-atom simulations of the C-terminal portion of the SARS-CoV-2/SARS-CoV Nsp1 in complex with the 40S ribosome disclose that SARS-CoV-2 Nsp1 has evolved from its SARS-CoV ortholog to more effectively hijack the ribosome by undergoing a critical switch of Q/E158 and E/Q159 residues that perfects Nsp1's interactions…