Search results for "SOM"
showing 10 items of 8346 documents
Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120.
2015
International audience; Modified nucleotide 5-methylcytosine (m(5)C) is frequently present in various eukaryotic RNAs, including tRNAs, rRNAs and in other non-coding RNAs, as well as in mRNAs. RNA: m(5)C-methyltranferases (MTases) Nop2 from S. cerevisiae and human proliferation-associated nucleolar antigen p120 are both members of a protein family called Nop2/NSUN/NOL1. Protein p120 is well-known as a tumor marker which is over-expressed in various cancer tissues. Using a combination of RNA bisulfite sequencing and HPLC-MS/MS analysis, we demonstrated here that p120 displays an RNA:m(5)C-MTase activity, which restores m(5)C formation at position 2870 in domain V of 25S rRNA in a nop2 Delta …
Absolute quantification of noncoding RNA by microscale thermophoresis
2019
Abstract Accurate quantification of the copy numbers of noncoding RNA has recently emerged as an urgent problem, with impact on fields such as RNA modification research, tissue differentiation, and others. Herein, we present a hybridization‐based approach that uses microscale thermophoresis (MST) as a very fast and highly precise readout to quantify, for example, single tRNA species with a turnaround time of about one hour. We developed MST to quantify the effect of tRNA toxins and of heat stress and RNA modification on single tRNA species. A comparative analysis also revealed significant differences to RNA‐Seq‐based quantification approaches, strongly suggesting a bias due to tRNA modifica…
Force Distribution Analysis of Mechanochemically Reactive Dimethylcyclobutene
2013
Internal molecular forces can guide chemical reactions, yet are not straightforwardly accessible within a quantum mechanical description of the reacting molecules. Here, we present a force-matching force distribution analysis (FM-FDA) to analyze internal forces in molecules. We simulated the ring opening of trans-3,4-dimethylcyclobutene (tDCB) with on-the-fly semiempirical molecular dynamics. The self-consistent density functional tight binding (SCC-DFTB) method accurately described the force-dependent ring-opening kinetics of tDCB, showing quantitative agreement with both experimental and computational data at higher levels. Mechanical force was applied in two different ways, namely, exter…
Sir Thomas More's Utopia : An overlooked economic classic
2019
Sir Thomas More's Utopia, published in 1516, is a classic work of how to organise a society based on common property. With a unique mix of common property, institutions and sound economic insights, we argue that More built a framework for a society that could be viable in the long run. While the conditions that make Utopia work are quite restrictive, it does provide a sketch of a society where common property may not stifle long‐term development, but is associated with productive workers and people content with their lives.
Somali Associations’ Trajectories in Italy and in Finland: Leaders building trust and finding legitimisation
2013
Previous research on migrant associations has explained their formation and maintenance by highlighting migrant groups' cultural characteristics or the political opportunity structures (POS) available in the countries of settlement. Past research has also focused on associations in relation to migrants' political participation in the countries of settlement, applying the notion of social capital. The aim of this article is to enrich the debate on migrant associations by analysing their trajectories. This analysis will also make use of the concepts of POS and social capital. The article analyses Somali associations' developmental trajectories over time in two different settlement-country con…
Strengthening Institutional Isomorphism in Development NGOs? Program Mechanisms in an Organizational Intervention
2017
Nongovernmental organizations (NGOs) in international development struggle between being actors in the mainstream or representatives of alternatives to it. However, many NGOs all over the world align with the mainstream and are increasingly similar to each other. This homogenization results from institutional isomorphism, which is affected by their aspirations to be legitimate vis-á-vis the international field. Consultancies are among the main practices to promote normative isomorphism, but little is known about their micro-level dynamics. Drawing on the notion of program mechanisms in realistic evaluation, we scrutinize how external facilitators in organizational development processes enab…
Six points à retenir sur les déterminants de la "juste" portion [expertise pour Nestlé]
2021
Membres du comité d'experts ayant participé à la réflexion :Sandrine Monnery-Patris ; Pascale Hebel ; Ghislain Grodard ; Thibaut de Saint Pol et Marie-Josèphe Amiot-Carlin Référence interne : EAPP; Nestlé a initié une réflexion avec un comité d'experts pluridisciplinaires indépendants pour identifier et comprendre les déterminants de la portion, levier essentiel, mais complexe, pour réguler la prise alimentaire.La synthèse de leurs réflexions s’articule en 6 points clés, soutenus par une analyse de la littérature scientifique, qui sont : • Une portion ni normée, ni injonctive• Une portion réaliste• Une portion personnalisée• Une portion associée à l’hédonisme• Une portion qui intègre les as…
SIA “Avenājs” attīstības iespēju izvērtējums
2016
Diplomdarba tēma ir “SIA “Avenājs” attīstības iespēju izvērtējums”. Par pētījuma objekti ir izvēlēts uzņēmums SIA “Avenājs”, tā darbības veids galvenokārt ir taksometru pakalpojumi. Diplomdarba mērķis ir apkopot un analizēt informāciju par taksometru pārvadājumiem Rīgā, analizēt uzņēmuma SIA “Avenājs” saimniecisko darbību, novērtēt finansiālo situāciju, izvērtēt attīstības iespējas, izstrādājot priekšlikumu turpmākai uzņēmuma attīstībai. Galvenie informācijas avoti ir SIA “Avenājs” nepublicētie materiāli un finanšu pārskati par periodu no 2010.gada līdz 2015.gadam Diplomdarbs sastāv no 3 daļām. Pirmajā nodaļā autore analīzes taksometru pārvadājumu nozari Rīgā; otrajā – uzņēmuma saimnieciskā…
Competing Decay Modes of a High-spin Isomer in the Proton-unbound Nucleus 158Ta
2015
An isomeric state at high spin and excitation energy was recently observed in the proton-unbound nucleus 158Ta. This state was observed to decay by both α and γ decay modes. The large spin change required to decay via γ-ray emission incurs a lifetime long enough for α decay to compete. The α decay has an energy of 8644(11) keV, which is among the highest observed in the region, a partial half-life of 440(70) µs and changes the spin by 11~. In this paper, additional evidence supporting the assignment of this α decay to the high-spin isomer in 158Ta will be presented. peerReviewed
Tradicionālā apģērba terminoloģijas tulkojums spēlē "Saliec tautastērpu!”
2021
Bakalaura darbā veikts galda spēlē “Saliec tautastērpu!” iekļauto somu tautastērpu aprakstu tulkojums no somu valodas latviski. Somu un latviešu tautastērpiem ir daudz līdzīgu iezīmju, tādēļ spēle var kalpot kā palīglīdzeklis, lai iepazītu somu kultūru. Problēma tulkojuma gaitā ir ar tautastērpu saistītās leksikas tulkošana, jo daudziem terminiem trūkst pietiekami precīza tulkojuma mērķvalodā vai tāds līdz šim nav izveidots vispār. Darba gaitā tiek apskatīti spēlē iekļautie specifiskās leksikas piemēri un izvēlētie to tulkojumi, balstoties uz Žana Pola Vinē, Žana Darbelnē un Monas Beikeres tulkošanas stratēģiju paņēmieniem. Šis darbs ir starpnozaru pētījums, jo tajā kultūrvēsturiski etnogrā…