Search results for "T1D"
showing 4 items of 4 documents
Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions.
2020
Type 2 diabetes (T2D) is a very prevalent, multisystemic, chronic metabolic disorder closely related to atherosclerosis and cardiovascular diseases. It is characterised by mitochondrial dysfunction and the presence of oxidative stress. Metformin is one of the safest and most effective anti-hyperglycaemic agents currently employed as first-line oral therapy for T2D. It has demonstrated additional beneficial effects, unrelated to its hypoglycaemic action, on weight loss and several diseases, such as cancer, cardiovascular disorders and metabolic diseases, including thyroid diseases. Despite the vast clinical experience gained over several decades of use, the mechanism of action of metformin i…
OCT is not useful for detection of minimal diabetic retinopathy in type 1 diabetes.
2009
Optical coherence tomography (OCT) has been proven useful in measuring retinal thickness (RT) in patients with diabetes, although with discordant results in different studies. We examined RT in patients with type 1 diabetes (T1D) with or without minimal diabetic retinopathy (MDR) to test whether OCT is able to identify early retinal changes and potential correlations with metabolic parameters. RT of 102 patients with T1D (53 females, 49 males, aged 27.03 +/- 7.4 years) and of 42 healthy controls was examined, with analysis of nine different sectors (fovea, four pericentral and four peripheral sectors). According to the results of basal fundus photography, patients were divided into two grou…
Combined therapy with insulin and rGH in thirteen Italian patients with type 1 diabetes (T1DM) and growth disorders.
2012
Background: Combined GH and insulin therapy are rarely prescribed in pediatric pts because the association of GHD and T1DM is rare and maybe for the difficulties in managing a double therapy with opposite effects on glucose metabolism. Objective and hypotheses: To investigate on the attitude of pediatric endo-diabetologists in treating these pts. Methods: Data were collected from over 50 centres belonging to the ISPED. The inclusion criterion was based on the double therapy for at least 6 months with insulin due to T1DM, and rGH, due to growth impairment. Results: Most centres stated that the use of combined therapy was considered uncomfortable and frequently avoided, whereas 10 centres rep…
Pirmā tipa cukura diabēta pacientu fiziskās aktivitātes līmeņa ietekme uz depresijas simptomiem
2021
Maģistra darba mērķis - Noskaidrot CD 1 pacientu fiziskās aktivitātes līmeņa asociāciju ar depresijas simptomiem. Pētījuma hipotēze - Fiziski aktīviem CD1 pacientiem ir zemāks depresijas pazīmju līmenis. Uzdevumi: 1.Noskaidrot CD 1 pacientu fiziskās aktivitātes līmeni; 2.Noskaidrot vai fiziskā aktivitāte un tās intensitāte ir saistīta ar depresijas simptomiem pacientiem ar CD 1; 3.Noskaidrot kādi faktori ir asociēti ar CD 1 pacientu depresijas simptomu attīstību; 4.Noskaidrot kādi faktori ir asociēti ar CD 1 pacientu fizisko aktivitāti. Pētījumā dizains - šķērsgriezuma pētījums ar sekundāro datu apstrādi. Iegūtie dati tika analizēti – ar SPSS, Excel, Word process. Pētījumā piedalījās 346 pa…