Search results for "TB"

showing 10 items of 2582 documents

LTB4 is present in exudative pleural effusions and contributes actively to neutrophil recruitment in the inflamed pleural space

2004

SUMMARY The pleural space is a virtual compartment between the lung and chest wall that becomes filled with fluid and inflammatory cells during a variety of respiratory diseases. Here, we study the potential role of the eicosanoid metabolite leukotriene B4 (LTB4) in disparate diseases leading to acute (pneumonia) or chronic (tuberculosis, cancer) inflammation of the pleural space. LTB4 concentrations were significantly higher in pleural fluid due to pneumonia, tuberculosis and cancer with respect to congestive heart failure and correlated with neutrophil elastase, which is used as an indication of state of activation of neutrophils in the pleural space. Moreover, pleural LTB4 was biological…

LipopolysaccharidesPathologyHot TemperatureNeutrophilsLeukotriene B4Gene ExpressionEpitheliumchemistry.chemical_compoundNeoplasmsClinical StudiesImmunology and AllergyMedicineRespiratory systemPancreatic ElastasebiologyNeutrophilMiddle Agedrespiratory systemChemotaxis Leukocytemedicine.anatomical_structureNeutrophil InfiltrationNeutrophil elastaseLTB4Pleuralipids (amino acids peptides and proteins)medicine.symptomAdultmedicine.medical_specialtyImmunologyInflammationGranulocyteLeukotriene B4HumansRNA MessengerTuberculosis PulmonaryAgedArachidonate 5-LipoxygenaseLungbusiness.industryPneumoniaMacrophage Activationmedicine.diseaserespiratory tract diseasesPleural EffusionPneumoniaEicosanoidchemistryImmunologybiology.proteinbusinessClinical and Experimental Immunology
researchProduct

Assessing the impact of COVID-19 on the management of patients with liver diseases: A national survey by the Italian association for the study of the…

2020

Abstract Background The COVID-19 pandemic had a huge impact on national and regional health systems. The impact of SARS-CoV-2 on the quality of care for patients with liver disease is still unknown. Aims The Italian Association for the Study of the Liver (AISF) conducted a survey to assess the impact of SARS-CoV-2 on hepatology units activities in Italy. Methods A prospective web-based survey was proposed to all AISF active members. The survey was available online from April 8 2020, to May 3 2020, (lockdown phase in Italy). Results 194 AISF members answered the questionnaire, most of whom were specialists in Gastroenterology (41%) or Internal Medicine (28%), and worked in Northern Italy (51…

Liver CirrhosisLiver disease0302 clinical medicineSurveys and QuestionnairesPandemicAmbulatory CareMass ScreeningParacentesisViralChronicLiver DiseasesLiver NeoplasmsGastroenterologyHepatology Covid-19 SARS COV-2Hepatitis BHepatitis CHospitalizationCovid-19; Hepatology; SARS COV-2Italy030220 oncology & carcinogenesis030211 gastroenterology & hepatologyCoronavirus Infectionsmedicine.medical_specialtyCarcinoma HepatocellularCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pneumonia ViralEsophageal and Gastric VaricesAntiviral AgentsArticle03 medical and health sciencesBetacoronavirusHepatitis B ChronicInternal medicinemedicineHumansPandemicsMass screeningQuality of Health CareHepatologybusiness.industrySARS-CoV-2SARS COV-2CarcinomaOutbreakCOVID-19HepatocellularPneumoniaHepatitis C ChronicHepatologymedicine.diseaseNorthern italyLiver TransplantationEmergency medicineChronic DiseaseCovid-19; Hepatology; SARS COV-2; Ambulatory Care; Antiviral Agents; Betacoronavirus; COVID-19; Carcinoma Hepatocellular; Chronic Disease; Coronavirus Infections; Esophageal and Gastric Varices; Gastroenterology; Hepatitis B Chronic; Hepatitis C Chronic; Hospitalization; Humans; Italy; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Liver Transplantation; Mass Screening; Pandemics; Paracentesis; Pneumonia Viral; Quality of Health Care; SARS-CoV-2; Surveys and Questionnairesbusiness
researchProduct

Economic Consequences of Investing in Anti-HCV Antiviral Treatment from the Italian NHS Perspective: A Real-World-Based Analysis of PITER Data

2019

OBJECTIVE:\ud We estimated the cost consequence of Italian National Health System (NHS) investment in direct-acting antiviral (DAA) therapy according to hepatitis C virus (HCV) treatment access policies in Italy.\ud \ud METHODS:\ud A multistate, 20-year time horizon Markov model of HCV liver disease progression was developed. Fibrosis stage, age and genotype distributions were derived from the Italian Platform for the Study of Viral Hepatitis Therapies (PITER) cohort. The treatment efficacy, disease progression probabilities and direct costs in each health state were obtained from the literature. The break-even point in time (BPT) was defined as the period of time required for the cumulativ…

Liver CirrhosisPediatricsTime FactorsSettore MED/09 - Medicina InternaNational Health ProgramsERADICATIONOUTBREAKantiviral treatment anti HCV economic consequencesHepacivirusLIVER FIBROSISSeverity of Illness IndexHealth Services AccessibilityCOST-EFFECTIVENESSIndirect costs0302 clinical medicineEpidemiologyvirus infection030212 general & internal medicinehealth care economics and organizationscost effectiveness030503 health policy & servicesHealth PolicyHealth services researchhealthHepatitis CHepatitis CMarkov Chainschronic hepatitis C virus infection fibrosis progression cost effectiveness liver fibrosisItalyPharmacology; Health Policy; Public Health Environmental and Occupational HealthCohortSettore SECS-P/03 - Scienza delle FinanzeDisease ProgressionPublic Health0305 other medical scienceViral hepatitisAnti-HCV antiviral treatmentCHRONIC HEPATITIS-Cmedicine.medical_specialtyGenotypeSettore MED/12 - GASTROENTEROLOGIAVIRUS-INFECTIONAntiviral AgentsNO03 medical and health sciencesCost SavingsAntiviral Agents; Cost Savings; Disease Progression; Genotype; Health Policy; Health Services Accessibility; Hepacivirus; Hepatitis C; Humans; Italy; Liver Cirrhosis; Markov Chains; National Health Programs; Severity of Illness Index; Time FactorsmedicineMANAGEMENTHumanschronic hepatitis CINDUCED DISEASESMETAANALYSISPharmacologyHealth economicsbusiness.industryPublic healthEnvironmental and Occupational HealthPublic Health Environmental and Occupational Healthmedicine.diseaseFIBROSIS PROGRESSIONbusiness
researchProduct

Long‐term neuropsychiatric outcomes in COVID‐19 survivors: A 1‐year longitudinal study

2021

Longitudinal studymedicine.medical_specialty2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)business.industrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)long‐COVIDCOVID-19CognitionTerm (time)cognitiveQuality of life (healthcare)psychiatricquality of lifeCOVID‐19Internal MedicineResearch LetterMedicineHumansLongitudinal StudiesSurvivorsbusinessPsychiatryJournal of Internal Medicine
researchProduct

Mikrotransakcijas kā e –komercijas veids video spēļu nozarē

2021

E – komercija ir viens no visātrāk augošākajiem komercijas veidiem gan Latvijā, gan pasaulē. Mikrotransakcijas ir viens no jaunākajiem e – komercijas paveidiem, kas lielākoties ir atrodams tikai video spēļu e – komercijas lauciņā. Bakalaura darba tēma: Mikrotransakcijas kā e – komercijas veids video spēļu nozarē Autors: Valters Lukstiņš Bakalaura darba mērķis: Iepazīties ar mikrotransakcijām kā jaunu e – komercijas veidu, to iespējamo sakarību ar azartspēlēm, veikt video spēļu industrijas tirgus apskatu un veikt video spēļu industrijas kompāniju ienākumu analīzi, kas piedāva mikrotransakciju pakalpojumus. Bakalaura darba struktūra: Ievads, 3 nodaļas, secinājumi un priekšlikumi Darba apjoms:…

LootboxVideospēlesEkonomikaMikrotransakcijaEkomercija
researchProduct

Atbildētības varbūtību novērtēšana izlases apsekojuma gadījumā

2016

Bakalaura darbs ir veltīts atbildētības varbūtību novērtēšanai izlases apsekojuma gadījumā. Atbildētības varbūtības sniedz statistiski pamatotu vērtējumu par to, ar kādu varbūtību respondents atbildēs uz konkrēto apsekojumu. Modeļa izstrādē izmantota loģistiskā regresija. Tad tiek izveidots simulāciju process, kurā tiek pielietota loģistiskā regresija, un tad tiek vērtēta novērtējuma precizitāte, izmantojot Montekarlo novirzi, Montekarlo standartnovirzi un kvadrātsakni no vidējās kvadrātiskās kļūdas. Datu statistiskā apstrāde un modeļa veidošana tiek veikta programmā R. Bakalaura darbs sastāv no 35 lappusēm, 1 attēla, 18 tabulām, 8 atsaucēm uz izmantotās literatūras avotiem un 1 pielikuma

Loģistiskā regresijaMatemātikaVienības neatbildētībaAtbildētības varbūtībaIzlases apsekojumi
researchProduct

The Deadly Quartet (Covid-19, Old Age, Lung Disease, and Heart Failure) Explains Why Coronavirus-Related Mortality in Northern Italy Was So High

2020

Since its outbreak in China at the end of 2019, the new coronavirus disease (COVID-19) was characterized by both easy spreading and high mortality. The latter proved to be way more elevated in the North of Italy -with a peak of 18.4% in region Lombardia and even 31% in the city of Bergamo and surrounding county- than in the rest of the world. In an attempt to conceptualize the reasons for such a dramatic situation, four key elements have been identified: COVID-19 itself, old age, lung disease, and heart failure. Their harmful combination has been named “The deadly quartet”. The underlying risk factors, among which a lot of them are distinctive features of the population in northern Italy, …

Lung Diseases0301 basic medicineCoronavirus disease 2019 (COVID-19)PopulationcoronavirusheartDiseasemedicine.disease_causeArticleDisease OutbreakslungScientific evidenceSettore MED/1103 medical and health sciences0302 clinical medicineRisk FactorsHumansMedicineChinaeducationAgedCoronavirusHeart Failureeducation.field_of_studySARS-CoV-2business.industryAge FactorsCOVID-19OutbreakGeneral Medicinemedicine.diseasemortality030104 developmental biologyItaly030220 oncology & carcinogenesisHeart failureCardiology and Cardiovascular MedicinebusinessDemographyCurrent Cardiology Reviews
researchProduct

Le traitement du dopage lors de l'Euro 2016

2016

International audience

Lutte contre le dopage[SHS.DROIT]Humanities and Social Sciences/Law[SHS.DROIT] Humanities and Social Sciences/LawPratique sportiveFootballComputingMilieux_MISCELLANEOUSSPORT
researchProduct

Identification of Cpgp40/15 Type Ib as the Predominant Allele in Isolates of Cryptosporidium spp. from a Waterborne Outbreak of Gastroenteritis in So…

2006

ABSTRACT Cryptosporidium sp. isolates from a waterborne outbreak of diarrhea in France were analyzed by PCR-restriction fragment length polymorphism analysis and sequencing of the Cpgp40/15 locus. Ninety-one percent of the isolates were Cryptosporidium hominis type Ib. The results of this study and those of studies of other outbreaks suggest that the type Ib allele is the predominant allele associated with waterborne cryptosporidiosis.

MESH : France/epidemiologyEpidemiologyMESH : polymerase chain reactionMESH : molecular sequence dataProtozoan ProteinsCryptosporidiosisPolymerase Chain Reactionlaw.inventionDisease OutbreaksMESH : Cryptosporidium/geneticsMESH : water/parasitologylaw[ SDV.MP ] Life Sciences [q-bio]/Microbiology and ParasitologyMESH : gastroenteritis/parasitologyMESH : Polymorphism restriction fragment lengthwaterborne outbreakPolymerase chain reactionbiologyMESH : DNA Protozoan/analysisCryptosporidiumGastroenteritisDiarrheaMESH : Cryptosporidiosis/epidemiologyFrancemedicine.symptomMESH : Cryptosporidium/classificationCryptosporidium hominisMESH : Protozoan proteins/metabolismPolymorphism Restriction Fragment LengthMicrobiology (medical)MESH : Cryptosporidium/isolation&purificationMolecular Sequence DataCryptosporidiumLocus (genetics)MESH : Disease outbreaksMicrobiologyMESH : Cryptosporidiosis/parasitologymedicineAnimalsAlleleGenotyping[SDV.MP] Life Sciences [q-bio]/Microbiology and ParasitologyAllelesMESH : animalsMESH : sequence analysis DNAOutbreakWaterSequence Analysis DNADNA Protozoanbiology.organism_classificationMESH : protozoan proteins/geneticsVirologygenotypingMESH : Gastroenteritis/epidemiologyMESH : Alleles
researchProduct

New Urban Metabolism

2014

Le città ecologiche e resilienti del futuro chiedono un nuovo sguardo e una rinnovata ecosofia che ne riveli le preziose “riserve di resilienza”, per troppo tempo invisibili agli occhi di chi le ha guardate solo come concentrato della rendita fondiaria o come generatrici di plusvalenze finanziarie. Le cellule resilienti al mutamento (frammenti di paesaggio, lacerti infrastrutturali, quartieri un riciclo funzionale, etc.) permettono alla città di assumere forme più elastiche, meno resistenti all'innovazione e più adattative, le consentono di attivare processi capaci di gestire un numero maggiore di problemi interagenti, di coinvolgere la pluralità degli attori e i variegati arcipelaghi socia…

METBOLISMO URBANO ECOLOGIA RIGENERAZIONE URBANASettore ICAR/21 - Urbanistica
researchProduct