Search results for "Tarea"
showing 10 items of 182 documents
New insights into the clinical and molecular spectrum of the novel CYFIP2-related neurodevelopmental disorder and impairment of the WRC-mediated acti…
2021
International audience; Purpose: A few de novo missense variants in the cytoplasmic FMRP-interacting protein 2 (CYFIP2) gene have recently been described as a novel cause of severe intellectual disability, seizures, and hypotonia in 18 individuals, with p.Arg87 substitutions in the majority.Methods: We assembled data from 19 newly identified and all 18 previously published individuals with CYFIP2 variants. By structural modeling and investigation of WAVE-regulatory complex (WRC)-mediated actin polymerization in six patient fibroblast lines we assessed the impact of CYFIP2 variants on the WRC.Results: Sixteen of 19 individuals harbor two previously described and 11 novel (likely) disease-ass…
Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders
2015
The pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community, Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons for this include lack of sensitivity/specificity of current screening methods, lack of reliable screening tests for some pathogens (e.g. prions) and the fact that many potentially harmful infectious agents are not routinely screened for. Methods for the purification/inactivation of blood/plasma-derived products have been developed in order to further reduce the residual risk, but low concentrations…
The Chinese Postman Problem with Load-Dependent Costs
2018
[EN] We introduce an interesting variant of the well-known Chinese postman problem (CPP). While in the CPP the cost of traversing an edge is a constant (equal to its length), in the variant we present here the cost of traversing an edge depends on its length and on the weight of the vehicle at the moment it is traversed. This problem is inspired by the perspective of minimizing pollution in transportation, since the amount of pollution emitted by a vehicle not only depends on the travel distance but also on its load, among other factors. We define the problem, study its computational complexity, provide two mathematical programming formulations, and propose two metaheuristics for its soluti…
El papel de la sílaba en la codificación posicional de las representaciones ortográficas
2012
El objetivo de este trabajo consiste en estudiar si la posición de las letras se codifica de una forma absoluta o relativa, y en particular, conocer el papel que la sílaba juega en la codificación de la información posicional dentro de las representaciones ortográficas. Para ello, empleamos dos experimentos con una tarea de solución de anagramas. En dicha tarea, se presenta un anagrama (CSIAGTO) y el participante tiene que descubrir la palabra que se forma ordenando las letras internas del anagrama (CASTIGO). Los resultados del Experimento 1 muestran un efecto de la presencia de bigramas adyacentes: los anagramas que mantienen un bigrama en una posición adyacente (CTGASIO) son resueltos con…
Non-autonomous rough semilinear PDEs and the multiplicative Sewing Lemma
2021
We investigate existence, uniqueness and regularity for local solutions of rough parabolic equations with subcritical noise of the form $du_t- L_tu_tdt= N(u_t)dt + \sum_{i = 1}^dF_i(u_t)d\mathbf X^i_t$ where $(L_t)_{t\in[0,T]}$ is a time-dependent family of unbounded operators acting on some scale of Banach spaces, while $\mathbf X\equiv(X,\mathbb X)$ is a two-step (non-necessarily geometric) rough path of H\"older regularity $\gamma >1/3.$ Besides dealing with non-autonomous evolution equations, our results also allow for unbounded operations in the noise term (up to some critical loss of regularity depending on that of the rough path $\mathbf X$). As a technical tool, we introduce a versi…
Ciudadanía de la familia y derecho-deber educativo de los padres
2021
El hombre no se define solo por su autonomía sino más bien por su relacionalidad, que se inicia con la filiación. A través de la tarea educativa los padres sostienen la libertad de los hijos en el camino de la vida, acompañándolos así hasta el cumplimiento de sus personas. La educación tiene como tarea propia la madurez personal, es decir, todo aquello que permite a una persona dirigir su vida en su globalidad, que se haga cargo de los elementos fundamentales que implica y a los que debe responder.
La autonomía progresiva del niño en los procesos de cuidado y custodia : comprensión del caso colombiano
2021
La posibilidad de participación de los menores de edad en los asuntos que les afectan es una dimensión de la autonomía progresiva; por eso, los procesos de guarda y custodia plantean un especial interés, particularmente si se opta por una custodia compartida. El estudio de los instrumentos internacionales, la jurisprudencia y la doctrina permiten una aproximación a los avances en la materia y las tareas que quedan aún pendientes.
Efectos de las tareas dobles en el rendimiento y aprendizaje motor en niños
2021
En el presente trabajo, nuestro objetivo fue evaluar el efecto que causa el entrenamiento de una tarea simple en comparación con el entrenamiento de una tarea doble para el desempeño del control postural y cognitivo en adolescentes. Así como poder establecer las diferencias en el control postural entre los adolescentes y los jóvenes adultos cuando realizan una doble tarea. METODOLOGÍA: En todos los estudios los datos de balanceo postural se obtuvieron usando la Wii Balance Board, y para medir el rendimiento cognitivo se utilizó la prueba de span test de dígitos inversos, que consistía en memorizar una secuencia de números y luego decirlos en orden inverso. En el primer estudio 13 adolescent…
Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk.
2006
Caspase-1 processes the interleukin (IL)-1β and IL-18 inactive precursors to the biologically active cytokines that are known to have proatherogenic effects. The present study investigated the genetic variability of the CASP1 gene and plasma levels of caspase-1 in relation to cardiovascular risk. In Europeans, 3 tag SNPs captured 4 common haplotypes of the CASP1 gene. Among these, the A in6 allele of the G+7/in6A polymorphism was less frequent in 246 cases with myocardial infarction and a parental history of disease than in 253 controls free of familial history of disease (0.13±0.02 versus 0.20±0.02; P =0.005). However, in a larger case/control study (n=1774), these effects are borderline …
Handgrip strength is associated with suicidal thoughts in men: Cross-sectional analyses from NHANES
2019
OBJECTIVE: To investigate the association between handgrip strength and suicidal thoughts in a representative sample of the US adult population using data from the National Health and Nutrition Examination Survey (NHANES). POPULATION AND METHODS: Data from two waves of NHANES (2011-2014) were aggregated. Handgrip strength in kilogram (kg) was defined as the maximum value from the dominant hand. Suicidal thoughts were assessed using one question "Over the last 2 weeks, how often have you been bothered by the following problem: Thoughts that you would be better off dead or of hurting yourself in some way?" and dichotomized to no (not at all) and yes (several days/ more than half the days/ nea…