Search results for "Unity"

Identification and characterization of autoantibodies against catalase and α-enolase in patients with primary sclerosing cholangitis

1998

SUMMARY Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology. Recent studies have shown that genetic factors and both cellular and humoral immunological abnormalities are important in the pathogenesis of PSC. The most prominent autoantibodies in PSC are anti-neutrophil cytoplasmic antibodies (ANCA). The autoepitopes of ANCA in PSC are not well defined. The aim of this study was to identify corresponding ANCA autoantigens in patients with PSC. A biochemical approach with enrichment and partial purification of soluble neutrophil proteins, detection of autoantibodies by Western blot and partial amino acid sequencing were used. Two new autoantigen/aut…

Autoimmune thyroid disease: new models of cell death in autoimmunity

2002

Autoimmunity to thyroid antigens leads to two distinct pathogenic processes with opposing clinical outcomes: hypothyroidism in Hashimoto's thyroiditis and hyperthyroidism in Graves' disease. The high frequency of these diseases and easy accessibility of the thyroid gland has allowed the identification of key pathogenic mechanisms in organ-specific autoimmune diseases. In early investigations, antibody- and T-cell-mediated death mechanisms were proposed as being responsible for autoimmune thyrocyte depletion. Later, studies on apoptosis have provided new insights into autoimmune target destruction, indicating the involvement of death receptors and cytokine-regulated apoptotic pathways in the…

Thyroid Stimulating Hormone Receptor Antibodies in Thyroid Eye Disease-Methodology and Clinical Applications.

2018

Background Thyroid stimulating hormone receptor antibodies (TSHR-Ab) cause autoimmune hyperthyroidism and are prevalent in patients with related thyroid eye disease (TED). Purpose To provide a historical perspective on TSHR-Ab and to present evidence-based recommendations for clinical contemporary use. Methods The authors review the recent literature pertaining to TSHR-Ab in patients with TED and describe the various immunoassays currently used for detecting TSHR-Ab and their clinical applications. Results We provide a historical summary and description of the various methods used to detect TSHR-Ab, foremost, the functional TSHR-Ab. Increasing experimental and clinical data demonstrate the …

Personality types in individuals with type 1 and type 2 diabetes

2020

Objective The Type A personality, characterized by impatience, strong career ambition and competitiveness, is associated with greater sensitivity to external stress. Type 1 diabetes (T1D) is an auto-immune disease, which is potentially influenced by stress, unlike type 2 diabetes (T2D). The aim of this study was to assess whether individuals with T1D and T2D exhibited significant differences on the Type A personality scale. We also assessed personality in patients with thyroid auto-immune diseases to validate potential links between auto-immune disease and Type A personality. Design and methods The Bortner questionnaire was used to assess Type A personality in 188 patients with T1D, 430 pa…

The Inflammatory Feed-Forward Loop Triggered by the Complement Component C3 as a Potential Target in Endometriosis

2021

Copyright © 2021 Agostinis, Zorzet, Balduit, Zito, Mangogna, Macor, Romano, Toffoli, Belmonte, Morello, Martorana, Borelli, Ricci, Kishore and Bulla. The complement system is a major component of humoral innate immunity, acting as a first line of defense against microbes via opsonization and lysis of pathogens. However, novel roles of the complement system in inflammatory and immunological processes, including in cancer, are emerging. Endometriosis (EM), a benign disease characterized by ectopic endometrial implants, shows certain unique features of cancer, such as the capacity to invade surrounding tissues, and in severe cases, metastatic properties. A defective immune surveillance against…

Educación artística : revista de investigación

2016

Resumen: El siguiente articulo pretende identificar posibles espacios comunes entre arte y educacion partiendo de la propuesta artistica Mapa dels Desitjos [1] del colectivo Crater [2] . Esta propuesta se llevo a cabo en el contexto de la XVII Mostra d’Art Public / Universitat Publica de la Universitat de Valencia. Mapa dels Desitjos surgio de la idea de preguntar a la comunidad universitaria como organizarian su vida si no tuviesen en cuenta la cuestion economica y de hacer publicas sus respuestas. A partir de esta experiencia, analizamos y reflexionamos en torno a cuatro preguntas que estructuran el analisis: ?Que paralelismos existen entre los roles de artista/publico y maestro/estudiant…

Analysis of Social Media Impact on Opportunity Recognition. A Social Networks and Entrepreneurial Alertness Mixed Approach

2020

This paper investigates the effects of social media on entrepreneurial opportunity recognition. Combining the internal and external approaches of opportunity recognition, the study analyzes how social media influences the entrepreneurs in discovering new entrepreneurial opportunities. Structural equation modeling was used in this study, using the variance-based partial least squares (PLS)&ndash

Evaluation and reasoning in the entrepreneurial opportunity process : narratives from sex industry entrepreneurs

2010

Influence of littoral periphyton on whole-lake metabolism relates to littoral vegetation in humic lakes

2017

The role of littoral habitats in lake metabolism has been underrated, especially in humic lakes, based on an assumption of low benthic primary production (PP) due to low light penetration into water. This assumption has been challenged by recent recognition of littoral epiphyton dominance of whole-lake PP in a small highly humic lake and of epiphyton as an important basal food source for humic lake biota. However, as these studies have mostly concerned single lakes, there is a need to test their wider generality. We studied the whole-lake PP and community respiration (CR) in eight small humic lakes in southern Finland during July 2015 using 14C incorporation to measure pelagic PP and the ch…

Iespēju vienlīdzība un ekonomikas izaugsme: gadījumu izpēte Eiropā

2021

Attīstoties filozofijai, sociālo zinātņu teorijai un ekonomikai, rezultātu vienlīdzību nomainīja iespēju vienlīdzība uzmanības centrā. Kaut arī Kuzņeca līkne nav dzelzs likums, nav pintes, lai to pārbaudītu, tā tomēr mums dod zināmu informāciju, kura atspoguļo to, cik " veselīga " ir mūsu attīstība. Šī maģistra darba mērķis ir izpētīt ekonomiskās izaugsmes ietekmi no iespēju egalitārisma viedokļa. Šī darba galvenā hipotēze ir sekojoša:  “Ekonomiskā izaugsme nelabvēlīgi ietekmē iespēju vienlīdzību attīstītajās valstīs noteiktā periodā.”  Runājot par iespēju vienlīdzības novērtējumu, šajā rakstā ir izmantots Iespēju indeksa modelis. IKP uz vienu iedzīvotāju tiek uzskatīts par mainīgo, lai ats…