Search results for "Unity"
showing 10 items of 3852 documents
SOUTH AMERICAN COLLABORATION IN SCIENTIFIC PUBLICATIONS ON LEISHMANIASIS: BIBLIOMETRIC ANALYSIS IN SCOPUS (2000-2011)
2014
Objetivos: Evaluar la producción y la red de colaboración de investigación sobre leishmaniasis en Sudamérica. Métodos: Se realizó un estudio bibliométrico usando la base de datos SCOPUS. La unidad de análisis fueron los artículos originales de investigación publicados desde el año 2000 hasta 2011, realizados sobre leishmaniasis y que incluyeron al menos un autor sudamericano. Se obtuvieron para cada artículo: nombre de la revista, idioma, año de publicación, número de autores, instituciones, países y otras variables. Resultados: 3174 artículos fueron publicados, 2.272 de ellos eran artículos originales. Se identificaron 1.160 firmas institucionales diferentes, 58 países y 398 revistas cient…
Effects of Service Learning on Physical Education Teacher Education Students’ Subjective Happiness, Prosocial Behavior, and Professional Learning
2020
Purpose: This study aims to analyze the effects of a service learning (SL) program on the subjective happiness (SH), prosocial behavior (PB), and professional learning (PL) perceptions of Physical Education Teacher Education (PETE) students as well as to examine the correlations among these variables. Methods: The study used a quasi-experimental design of two non-equivalent groups (control and experimental) comparing pre-test and post-test data. The instruments used were the Subjective Happiness Scale, the Prosocial and Civic Competence questionnaire, and the Impact of Service Learning during Initial Training of Physical Activity and Sports questionnaire. Results: Data indicated that SL onl…
Problemy współczesnej genologii medialnej
2020
The paper is an attempt at clarifying the object of research into media genology, distancing itself from literary studies genology. In the era of convergence of mass media, we can observe a progress in the blurring of the border between information and journalism, which consequently changes the contemporary communicative convention. As a result, information services are often degraded and the sense of implementing ‘traditional’ indicators of mass media genres is questioned. The change of communicative convention in contemporary mass media requires, above all, the use of cultural context for its analysis, as it determines the methods of creating messages and means of receiving them. It also …
Community response to environmental noise in Valencia
1990
Abstract In Valencia, Spain, 263 residents were interviewed at five different locations in order to investigate the subjective response to environmental noise in urban areas. External noise levels were measured over five consecutive days at each site. Noise levels were high in two of the selected sites ( L eq 24h about 75 dBA) and lower in the other two ( L eq 24h about 65 dBA). The fifth location had a night noise problem because of the presence of many leisure places (pubs, restaurants, etc.). The scores of the sample with their satisfaction with their neighbourhood were notably higher in the quiet than in the noisy areas (83% and 64% respectively). Road traffic and pub noise (in the fift…
A Cost–Benefit Based, Parametric Procedure to Screen Existing Irrigation and Municipal Supply Reservoirs for Wind Energy Storage
2018
Pumped hydro storage (PHS) is one of the more suitable energy storage technologies to provide bulk storage of intermittent renewable energy sources (RES) such as wind. Since the main limiting factors to the expansion of this mature technology are environmental and financial concerns, the use of an existing reservoir can help mitigate both types of impacts. In addition, the high number of reservoirs for municipal and irrigation supply in many areas of the world makes the idea of using PHS as a relatively diffuse, open-market, technology for RES management attractive. These arguments in favor of PHS must, however, be convincing for investors and regulators from an economic standpoint. To this…
Macrophages as an Emerging Source of Wnt Ligands: Relevance in Mucosal Integrity
2019
The Wnt signaling pathway is a conserved pathway involved in important cellular processes such as the control of embryonic development, cellular polarity, cellular migration, and cell proliferation. In addition to playing a central role during embryogenesis, this pathway is also an essential part of adult homeostasis. Indeed, it controls the proliferation of epithelial cells in different organs such as intestine, lung, and kidney, and guarantees the maintenance of the mucosa in physiological conditions. The origin of this molecular pathway is the binding between Wnt ligands (belonging to a family of 19 different homologous secreted glycoproteins) and their specific membrane receptors, from …
F-Type Lectins: A highly diversified family of fucose-binding proteins with a unique sequence motif and structural fold, involved in self/non-self-re…
2017
The F-type lectin (FTL) family is one of the most recent to be identified and structurally characterized. Members of the FTL family are characterized by a fucose recognition domain [F-type lectin domain (FTLD)] that displays a novel jellyroll fold (“F-type” fold) and unique carbohydrate- and calcium-binding sequence motifs. This novel lectin family comprises widely distributed proteins exhibiting single, double, or greater multiples of the FTLD, either tandemly arrayed or combined with other structurally and functionally distinct domains, yielding lectin subunits of pleiotropic properties even within a single species. Furthermore, the extraordinary variability of FTL sequences (isoforms) th…
Serological Levels of Anti-clathrin Antibodies Are Decreased in Patients With Pseudoexfoliation Glaucoma
2021
Evidence for immunologic contribution to glaucoma pathophysiology is steadily increasing in ophthalmic research. Particularly, an altered abundance of circulating autoantibodies to ocular antigens is frequently observed. Here, we report an analysis of autoantibody abundancies to selected antigens in sera of open-angle glaucoma patients, subdivided into normal-tension glaucoma (N = 31), primary open-angle glaucoma (N = 43) and pseudoexfoliation glaucoma (N = 45), vs. a non-glaucomatous control group (N = 46). Serum samples were analyzed by protein microarray, including 38 antigens. Differences in antibody levels were assessed by ANOVA. Five serological antibodies showed significantly altered…
RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis—Novel Targets for Therapy?
2019
Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and several genes (IL23R, IL6R, STAT3, JAK2, IL1R1/2, IL12B, and IL7R) involved in IL23 driven pathways of inflammation. AS is also strongly associated with polymorphisms in two transcription factors, RUNX3 and T-bet (encoded by TBX21), which are important in T-cell development and function. The influence of these genes on the pathogenesis of AS and their potential for identifying drug targets is discussed here.
Autoantigens in the trabecular meshwork and glaucoma‐specific alterations in the natural autoantibody repertoire
2019
Abstract Objectives Primary open‐angle glaucoma (POAG) is a neurodegenerative disorder leading to a gradual vision loss caused by progressive damage to the optic nerve. Immunological processes are proposed to be involved in POAG pathogenesis. Altered serological autoantibody levels have been frequently reported, but complete analyses of the natural autoantibodies with respect to disease‐related alterations are scarce. Here, we provide an explorative analysis of pathways and biological processes that may involve naturally immunogenic proteins and highlight POAG‐specific alterations. Methods Mass spectrometry‐based antibody‐mediated identification of autoantigens (MS‐AMIDA) was carried out in…