Search results for "VARIATION"

showing 10 items of 2124 documents

Short-Term Precision Error of Bone Strain Index, a New DXA-Based Finite Element Analysis Software for Assessing Hip Strength

2020

Abstract Bone Strain Index (BSI) is a new finite element analysis tool applied to hip dual energy X-ray absorptiometry scans. The aim of this study was to assess the short-term precision error of BSI on the proximal femur, both on a phantom and patients. The International Society for Clinical Densitometry guidelines were followed for short-term precision error assessment. Dual energy X-ray absorptiometry measurements were performed on an anthropomorphic femur phantom that was scanned twice for 30 times, for a total of 60 scans. For the in vivo part, 30 subjects were scanned twice. BSI precision error was compared to that of bone mineral density (BMD). Both for the phantom and the in vivo st…

Malemusculoskeletal diseases0301 basic medicineEndocrinology Diabetes and MetabolismCoefficient of variationFinite Element Analysis030209 endocrinology & metabolismPatient PositioningImaging phantom03 medical and health sciencesAbsorptiometry Photon0302 clinical medicineBone DensitymedicineHumansRadiology Nuclear Medicine and imagingOrthopedics and Sports MedicineFemurFemurDual-energy X-ray absorptiometryAgedFemoral neckBone mineralReproducibilitymedicine.diagnostic_testPhantoms Imagingbusiness.industryReproducibility of Resultsbacterial infections and mycosesmedicine.anatomical_structureOsteoporosisFemale030101 anatomy & morphologyDensitometrybusinessNuclear medicinehuman activitiesSoftwareJournal of Clinical Densitometry
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Overlapping phenotypes between SHORT and Noonan syndromes in patients with PTPN11 pathogenic variants

2020

Overlapping syndromes such as Noonan, Cardio-Facio-Cutaneous, Noonan syndrome (NS) with multiple lentigines and Costello syndromes are genetically heterogeneous conditions sharing a dysregulation of the RAS/mitogen-activated protein kinase (MAPK) pathway and are known collectively as the RASopathies. PTPN11 was the first disease-causing gene identified in NS and remains the more prevalent. We report seven patients from three families presenting heterozygous missense variants in PTPN11 probably responsible for a disease phenotype distinct from the classical Noonan syndrome. The clinical presentation and common features of these seven cases overlap with the SHORT syndrome. The latter is the c…

Malemusculoskeletal diseases0301 basic medicineMAPK/ERK pathwaycongenital hereditary and neonatal diseases and abnormalitiesMAP Kinase Signaling SystemProtein Tyrosine Phosphatase Non-Receptor Type 11030105 genetics & heredityBiologyGene productPhosphatidylinositol 3-Kinases03 medical and health sciencesMetabolic DiseasesGeneticsmedicineHumansMissense mutationskin and connective tissue diseasesProtein kinase BGrowth DisordersGenetics (clinical)GeneticsGenetic heterogeneityNoonan SyndromeGenetic Variationmedicine.diseasePTPN11NephrocalcinosisPhenotype030104 developmental biologySHORT syndromeHypercalcemiaNoonan syndromeFemaleMitogen-Activated Protein KinasesSignal TransductionClinical Genetics
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Sprint Time Differences Between Single- and Dual-Beam Timing Systems

2014

Valid and reliable measures of sprint times are necessary to detect genuine changes in sprinting performance. It is currently difficult for practitioners to assess which timing system meets this demand within the constraints of a proper cost-benefit analysis. The purpose of this investigation was to quantify sprint time differences between single-beam (SB) and dual-beam (DB) timing systems. Single-beam and DB photocells were placed at 0, 20, and 40 m to compare 0-20 and 20-40 m sprint times. To control for the influence of swinging limbs between devices, 2 recreationally active participants cycled as fast as possible through the track 25 times with a 160-cm tube (18 cm diameter) vertically …

Malesports equipmentTime FactorsAdolescentCoefficient of variationTiming systemSPRINTING PERFORMANCEReproducibility of ResultsPhysical Therapy Sports Therapy and RehabilitationEquipment DesignGeneral MedicineAthletic PerformanceDual beamBicyclingRunningSports EquipmentYoung AdultSprintHumansFemaleOrthopedics and Sports MedicineSimulationMathematicsJournal of Strength and Conditioning Research
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Pan-cancer analysis of whole genomes

2020

Publisher's version (útgefin grein)

Maletert promoter mutationsCancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]DNA Mutational AnalysisNormal tissuesystematic analysisGermlineTranscriptome0302 clinical medicineAetiologyCàncerCellular SenescenceCancer0303 health sciencesdna-damageMassive parallel sequencingPan cancerREARRANGEMENTSHigh-Throughput Nucleotide SequencingGenomicsSciences bio-médicales et agricolesTelomereCOMPREHENSIVE3. Good healthTERT PROMOTER MUTATIONSsignatures030220 oncology & carcinogenesisScience & Technology - Other TopicsErfðarannsóknirHuman:Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]EvolutionRNA SplicingGenomicsArticleEvolution MolecularStructural variationRC025403 medical and health sciencesSDG 3 - Good Health and Well-beingGeneticgenomicsSYSTEMATIC ANALYSISGeneticsGenomics--Databases.HumansGenetic TestingMolecular BiologySIGNATURESWhole genome sequencing1000 MultidisciplinaryChromothripsisScience & TechnologyRC0254 Neoplasms. Tumors. Oncology (including Cancer)Information DisseminationResearchInstitutes_Networks_Beacons/mcrcPreventionBiology and Life SciencesMolecularOncogenesCloud Computingmedicine.diseaseGenòmicaCompute cloudsMutation570 Life sciences; biologyCOMPREHENSIVE CHARACTERIZATIONGenèticaWhole Genome Sequencing--methodsBackground informationDNA Mutational Analysis ; Evolution ; Genetic / genetics ; Genome ; Genomics ; Germ-Line Mutation / genetics ; High-Throughput Nucleotide Sequencing ; Human / genetics ; Humans ; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumMedizinGenomeWhole-genomeGenome mappingNeoplasms2.1 Biological and endogenous factorsPromoter Regions GeneticCàncer -- Aspectes genèticsTelomeraseGeneticsWomen's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]MultidisciplinaryChromothripsisGenomeManchester Cancer Research Centregenomics cancer profiling3rd-DAS10124 Institute of Molecular Life SciencesWomen's cancers Radboud Institute for Health Sciences [Radboudumc 17]Multidisciplinary SciencesParallel sequencingICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumFemaleprofilingMedical GeneticsEngineering sciences. TechnologyBiotechnologyGeneral Science & TechnologyThe Cancer Genome Atlas610 Medicine & healthComputational biologyQH426 GeneticsBiologyConsortium of the International Cancer Genome ConsortiumPromoter RegionsGermline mutationPan-cancer analysisKrabbameinsrannsóknirmedicinecancerddc:610QH426Germ-Line MutationMedicinsk genetikKrabbamein030304 developmental biologyCell ProliferationLANDSCAPEGenome Humancomprehensive characterizationPan-cancer analysis of whole genomesPoint mutationHuman GenomeCancerReproducibility of ResultsSOMATIC MUTATIONSEVOLUTIONCancer sequencing Chromothripsis telomereDNA-DAMAGEMutagenesisPATTERNS3111 BiomedicineCHARACTERIZATION
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Secular trends in moderate-to-vigorous physical activity in 32 countries from 2002 to 2010: a cross-national perspective

2015

Background: Sufficient levels of moderate to vigorous physical activity (MVPA) give substantial health benefits to adolescents. This article examines trends in physical activity (PA) from 2002 to 2010 across 32 countries from Europe and North America. Methods: Representative samples included 479 674 pupils (49% boys) aged 11 years ( n = 156 383), 13 years ( n = 163 729) and 15 years ( n = 159 562). The trends in meeting the recommendations for PA (at least 60 min daily) were evaluated using logistic regression. Results: There was a slight overall increase between 2002 and 2010 (17.0% and 18.6%, respectively). MVPA increased significantly ( P ≤ 0.05) among boys in 16 countries. Conversely, n…

MaletrendsPediatricsmedicine.medical_specialtyAdolescentAdolescent HealthPhysical activityHealth benefitsLogistic regressionmedicineHumansadolescentsChildExercisebusiness.industrymoderate-to-vigorous physical activityPublic Health Environmental and Occupational Healthta3141ta3142Health SurveysSecular variationEuropeAdolescent BehaviorNorth AmericaFemalebusinessCross nationalDemographyAdolescent health
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Environmental Correlates of Motor Competence in Children -The Skilled Kids Study

2019

Environment, physical activity (PA) and motor development are tightly interwoven during childhood. We examined the associations of environmental factors with motor competence (MC) in children. Children (N = 945, 50.1% boys, age = 3–7 years, mean = 5.4 years) from 37 childcare centres in the Southern (n = 17), Central (n = 13) and Northern Finland (n = 7) participated. The environmental factors comprised the geographical location (Southern, Central and Northern Finland) and residential density (metropolitan area, city, rural area and countryside) of the childcare centres’ based on postal codes and the national population density registry. MC was measured using the Test of Gross Motor Develop…

Maleulkoiluparticipation in sportsympäristöFITNESSHealth Toxicology and Mutagenesisresidential densityasuinympäristöPoison controllcsh:MedicineLANGUAGESuicide preventionOccupational safety and health0302 clinical medicineSurveys and QuestionnairesADOLESCENTS030212 general & internal medicinegeographical locationChildFinlandMotor skillASSOCIATIONSoutdoor timeSEDENTARY BEHAVIORmotor competenceMotor SkillsCOGNITIVE-DEVELOPMENTChild PreschoolFemalePsychologyenvironmentfyysinen aktiivisuusSportsINTERVENTIONSympäristötekijätSEASONAL-VARIATIONGross motor skilllapset (ikäryhmät)Article03 medical and health scienceschildrenInjury preventionHumansmotoriset taidotliikuntaharrastusExerciseDemographylcsh:RPublic Health Environmental and Occupational Health030229 sport sciencesPERFORMANCEMetropolitan areaPHYSICAL-ACTIVITYRural areaDemographyInternational Journal of Environmental Research and Public Health
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Le metamorfosi del corale "Vom Himmel hoch da komm ich her" fra Lutero, Bach e Stravinsky

2020

Il corale matalizio "Vom Himmel hoch da komm ich her" (Dall'alto dei cieli io giungo) è stato realizzato da Martin Lutero sulla base della melodia popolare "Ich komm aus fremden Landen her" e fu pubblicato per la prima volta a Wittenberg nel 1535. Assai diffuso in tutta l'area culturale tedesca, questo brano è stato ripreso, tra gli altri, anche da J.S. Bach, sia nel "Weinachts-Oratorium" BWV 248 che nelle "Canonische Veraenderungen" per organo BWV 796 e 796a. Il saggio ricostruisce il contesto in cui vide la luce la versione originale del canto natalizio e si sofferma sull'interesse di Bach per la numerologia e sulle "citazioni nascoste" in molte sue opere, incluse le "Veraenderungen" sul …

Martin Lutero corale natalizio "Vom Himmel Hoch da komm ich her" Johann Sebastian Bach "Weinachts-Oratorium" BWV 248"Canonische Veraenderenderungen" BVW 796 e 796aVenice "Canticum Sacrum" "Choral-Variationen" Anton Webern.Igor Stravinsky Robert CraftvENEZIA "Canticum Sacrum" "Choral-Variationen" Anton Webern.Martin Luther christmas charol "Vom Himmel Hoch da komm ich her" Johann Sebastian Bach "Weinachts-Oratorium" BWV 248Settore L-ART/07 - Musicologia E Storia Della Musica
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Musica e architettura. Le opere di Igor Stravinsky per la basilica di San Marco a Venezia

2019

Il 13 settembre 1956, Stravinsky diresse nella basilica di San Marco a Venezia la prima esecuzione del "Canticum Sacrum" (1955), insieme con le "Variazioni-corali sulla canto natalizio Vom Himmel hoch…" (1955-56). Il "Canticum" era stato realizzato su commissione del Festival delle Biennale e costituisce un esempio dell'approccio del compositore alla tecnica dodecafonica. Le "Variazioni-corali" presentano quasi il medesimo organico del "Canticum" e sono invece da considerarsi come una sorta di ripensamento creativo delle "Variazioni canoniche" BWV 796-796a di Johann Sebastian Bach. September 13th 1956, Stravinsky conducted at the basilica of St. Mark in Venice the first performance of the "…

Martin LutherserialismVeneziacoraleIgor StravinskyvariazioneJohann Sebastian BachchoralCanticum Sacrumbasilica di San MarcoVeniceVariazioni-corali sul canto natalizio Vom Himmel hochbasilica of St. MarkChoral-Variations on the Christmas Carol Vom Himmel hochMartin LuteroSettore L-ART/07 - Musicologia E Storia Della Musicavariationtrascrizioneserialismo
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Description of light nuclei in pionless effective field theory using the stochastic variational method

2016

We construct a coordinate-space potential based on pionless effective field theory with a Gaussian regulator. Charge-symmetry breaking is included through the Coulomb potential and through two- and three-body contact interactions. Starting with the effective field theory potential, we apply the stochastic variational method to determine the ground states of nuclei with mass number $A\leq 4$. At next-to-next-to-leading order, two out of three independent three-body parameters can be fitted to the three-body binding energies. To fix the remaining one, we look for a simultaneous description of the binding energy of $^4$He and the charge radii of $^3$He and $^4$He. We show that at the order con…

Mass numberPhysicsNuclear Theory010308 nuclear & particles physicsGaussianBinding energyOrder (ring theory)FOS: Physical sciencesCharge (physics)01 natural sciencesNuclear Theory (nucl-th)symbols.namesakeVariational methodQuantum electrodynamics0103 physical sciencesEffective field theorysymbolsElectric potential010306 general physicsMathematical physics
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In vitro carious lesion detection on D-, E-, and F-speed radiographic films

2004

Abstract Objectives To compare the accuracy in detection of interproximal natural carious lesions in vitro between Ultraspeed (D), Ektaspeed Plus (E), and Insight (F) radiographic films. Study design Ten observers indicated on a 5-point scale their confidence in detecting an interproximal lesion in 240 surfaces (120 extracted teeth) with noncavitated carious lesions. Truth was assessed microscopically from hemisections. The areas (Az) beneath receiver operating characteristic (ROC) curves were pairwise compared and used for a 2-way analysis of variance. Results Az values were significantly correlated with observers ( P  = .002; Eta = 0.671) and film type ( P  = .003; Eta = 0.412). E differe…

Matched-Pair AnalysisRadiographic FilmsDentistryDental CariesDiagnosis DifferentialLesionConfidence IntervalsRadiography DentalmedicineHumansGeneral DentistryObserver VariationAnalysis of VarianceReceiver operating characteristicbusiness.industryX-Ray FilmConfidence intervalROC CurveOtorhinolaryngologyArea Under CurveSurgeryCarious lesionOral Surgerymedicine.symptomNuclear medicinebusinessOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
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