Search results for "Virus Disease"
showing 10 items of 1907 documents
Prevalence of sexually transmitted infections and enteric protozoa among homosexual men in western Sicily (south Italy)
2012
Introduction. In recent years an increase in the number of sexu- ally transmitted infections (STIs) in men who have sex with men (MSM) has been reported in different industrialised countries. Because few epidemiological data on the STIs/MSM population in Sicily are available, a survey was conducted to assess the preva- lence of STIs/enteric protozoa and risky sexual behaviours among MSM in western Sicily. Methods. In 2010, 74 MSM with median age of 30 years old, were recruited via networks. All participants to the study were interviewed by anonymous self-administered questionnaire in order to collect social/demographic information, clinic data and STI-related risky sexual behaviours. After …
Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1)…
2014
Although the addition of the HCV NS3/4A protease inhibitors boceprevir and telaprevir to pegylated interferon (peginterferon) alfa plus ribavirin has improved sustained virological response (SVR) in treatment-naive and treatment-experienced patients infected with hepatitis C virus (HCV) genotype 1, the regimens have a high pill burden and are associated with increased rates and severity of adverse events, such as anaemia and rash. The efficacy and safety of the combination of simeprevir, a one pill, once-daily, oral HCV NS3/4A protease inhibitor, plus peginterferon alfa 2a plus ribavirin were assessed in treatment-naive patients with HCV genotype 1 infection.In QUEST-1, a phase 3, randomise…
Anam-Net: Anamorphic Depth Embedding-Based Lightweight CNN for Segmentation of Anomalies in COVID-19 Chest CT Images.
2021
Chest computed tomography (CT) imaging has become indispensable for staging and managing coronavirus disease 2019 (COVID-19), and current evaluation of anomalies/abnormalities associated with COVID-19 has been performed majorly by the visual score. The development of automated methods for quantifying COVID-19 abnormalities in these CT images is invaluable to clinicians. The hallmark of COVID-19 in chest CT images is the presence of ground-glass opacities in the lung region, which are tedious to segment manually. We propose anamorphic depth embedding-based lightweight CNN, called Anam-Net, to segment anomalies in COVID-19 chest CT images. The proposed Anam-Net has 7.8 times fewer parameters …
Tetraspanin CD151 Mediates Papillomavirus Type 16 Endocytosis
2013
ABSTRACT Human papillomavirus type 16 (HPV16) is the primary etiologic agent for cervical cancer. The infectious entry of HPV16 into cells occurs via a so-far poorly characterized clathrin- and caveolin-independent endocytic pathway, which involves tetraspanin proteins and actin. In this study, we investigated the specific role of the tetraspanin CD151 in the early steps of HPV16 infection. We show that surface-bound HPV16 moves together with CD151 within the plane of the membrane before they cointernalize into endosomes. Depletion of endogenous CD151 did not affect binding of viral particles to cells but resulted in reduction of HPV16 endocytosis. HPV16 uptake is dependent on the C-termina…
A bioweapon or a hoax? The link between distinct conspiracy beliefs about the Coronavirus disease (COVID-19) outbreak and pandemic behavior
2020
During the coronavirus disease pandemic rising in 2020, governments and nongovernmental organizations across the globe have taken great efforts to curb the infection rate by promoting or legally prescribing behavior that can reduce the spread of the virus. At the same time, this pandemic has given rise to speculations and conspiracy theories. Conspiracy worldviews have been connected to refusal to trust science, the biomedical model of disease, and legal means of political engagement in previous research. In three studies from the United States ( N = 220; N = 288) and the UK ( N = 298), we went beyond this focus on a general conspiracy worldview and tested the idea that different forms of …
Resilience and Parental Burnout Among Finnish Parents During the COVID-19 Pandemic: Variable and Person-Oriented Approaches.
2021
During the coronavirus disease 2019 (COVID-19) crisis, different personality characteristics may have influenced parental well-being in different ways. In the present study, we combined variable and person-oriented approaches and examined relationships between resilience, parental burnout, and perfectionism during the lockdown. We first used structural equation modeling to assess the paths between variables. We then used latent profile analysis to examine different profiles of parents based on resilience, perfectionism, and symptoms of parental burnout. Finally, we examined how these profiles differ in terms of relevant background variables. The results showed that resilience predicted par…
Los cambios en la gestión del régimen de clases pasivas: ¿un ataque a las singularidades de los regímenes especiales de funcionarios?
2020
El objetivo de este trabajo es analizar los cambios en la gestión del régimen de clases pasivas aprobados durante el 2020 dentro de la legislación de urgencia suscrita durante el estado de alarma. El traspaso de la gestión al Instituto Nacional de Seguridad Social plantea tres cuestiones: primero, si el traspaso es técnicamente adecuado; segundo, por qué se ha efectuado en un real decreto ley de medidas para paliar los efectos económicos del COVID-19 una medida que afecta a la gestión de las pensiones de funcionarios, y, tercero, qué puede suponer este cambio de gestión para las especialidades contenidas en este régimen especial. The objective of this paper is to analyze the changes in the …
Presentación del debate: Impactos sociales de COVID-19: un nuevo reto para la sociología
2020
La pandemia COVID-19 ha convulsionado el mundo, y la sociología debe ser protagonista en la lectura e interpretación de estos movimientos, contribuyendo, además, a la construcción de propuestas a los problemas que se vislumbran. Más allá de un fenómeno epidemiológico y sanitario, la pandemia es también un fenómeno sociológico, y las medidas que se propongan también han de serlo. Esto supone que no solo hay que indagar el agente causante de la pandemia de naturaleza biológica, sino también los determinantes sociales de la salud, y los efectos de las medidas adoptadas en la vida social.
Does the platform matter? Social media and COVID-19 conspiracy theory beliefs in 17 countries
2021
While the role of social media in the spread of conspiracy theories has received much attention, a key deficit in previous research is the lack of distinction between different types of platforms. This study places the role of social media affordances in facilitating the spread of conspiracy beliefs at the center of its enquiry. We examine the relationship between platform use and conspiracy theory beliefs related to the COVID-19 pandemic. Relying on the concept of technological affordances, we theorize that variation across key features make some platforms more fertile places for conspiracy beliefs than others. Using data from a crossnational dataset based on a two-wave online survey cond…
Phylogenetic analysis in the clinical risk management of an outbreak of hepatitis C virus infection among transfused thalassaemia patients in Italy
2021
Background: Occurrence of hepatitis C virus (HCV) infection is reduced by effective risk management procedures, but patient-to-patient transmission continues to be reported in healthcare settings. Aim: To report the use of phylogenetic analysis in the clinical risk management of an HCV outbreak among 128 thalassaemia outpatients followed at a thalassaemia centre of an Italian hospital. Methods: Epidemiological investigation and root-cause analysis were performed. All patients with acute hepatitis and known chronic infection were tested for HCV RNA, HCV genotyping, and NS3, NS5A, and NS5B HCV genomic region sequencing. To identify transmission clusters, phylogenetic trees were built for each…