Search results for "WES"

Novel Munc13-4 mutations in children and young adult patients with haemophagocytic lymphohistiocytosis

2006

Familial haemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous disorder characterised by constitutive defects in cellular cytotoxicity resulting in fever, hepatosplenomegaly and cytopenia, and the outcome is fatal unless treated by chemoimmunotherapy followed by haematopoietic stem‐cell transplantation. Since 1999, mutations in the perforin gene giving rise to this disease have been identified; however, these account only for 40% of cases. Lack of a genetic marker hampers the diagnosis, suitability for transplantation, selection of familial donors, identification of carriers, genetic counselling and prenatal diagnosis. Mutations in the Munc13–4 gene have recently been des…

West Nile virus in Spain: Forecasting the geographical distribution of risky areas with an ecological niche modelling approach.

2021

West Nile virus (WNV), a well-known emerging vector-borne arbovirus with a zoonotic life cycle, represents a threat to both public and animal health. Transmitted by ornithophilic mosquitoes, its transmission is difficult to predict and even more difficult to prevent. The massive and unprecedented number of human cases and equid outbreaks in Spain during 2020 interpellates for new approaches. For the first time, we present an integrate analysis from a niche perspective to provide an insight to the situation of West Nile disease (WND) in Spain. Our modelling approach benefits from the combined use of global occurrence records of outbreaks of WND in equids and of its two alleged main vectors i…

Will the invasive western conifer seed bug Leptoglossus occidentalis Heidemann (Hemiptera: Heteroptera: Coreidae) seize all of Europe?

2008

In our day, thanks to high-speed transport systems, people are moving living species (intentionally or not) across ecosystems and countless borders. As we know, most introduced species usually do not survive, because they find neither a tolerable environment nor an available ecological niche. Sometimes, successful establishment may also require multiple introductions (Balcom 2004).

Paleodiversity of the Superfamily Ursoidea (Carnivora, Mammalia) in the Spanish Neogene, related to environmental changes

2014

In the present study we analyse the diversity of the Superfamily Ursoidea during the Neogene of the Iberian Peninsula to further compare it with that of the Neogene of Western Europe to find the different associations of this group. The results indicate that both the diversity and the taxonomy amongst these two regions show important variations, thus letting their interpretation in terms of climatic differentiation. We might relate variations in the abundance of the Ursoidea to the environmental fluctuations taking place during the Miocene and Pliocene. Therefore, they could enable us to reach the assessment of these biogeographical distributions in order to deduce the preferential niches o…

Nutrient element and carbohydrate status of Norway spruce at Mt. Kleiner Feldberg in Taunus exposed to air pollution and soil acidification

1988

An unidentified harvestman Leiobunum sp. alarmingly invading Europe (Arachnida: Opiliones)

2007

Etwa seit dem Jahr 2000 breitet sich eine bisher nicht identifizierte Art der Gattung Leiobunum C. L. Koch, 1839 schnell in Mitteleuropa aus. Nachweise ab dem Jahr 2004 sind aus den Niederlanden (wahrscheinlich dem Land des ersten Auftretens in Europa), Deutschland, Österreich und der Schweiz bekannt. Die wahrscheinlich eingeschleppte Art besiedelt bisher lediglich Wände von Gebäuden und seltener felsähnliche Biotope in Wäldern. Adulte Individuen ruhen tagsüber selten einzeln oder in eng geklumpten Gruppen aus Dutzenden bis Hunderten von Individuen an leicht abgedunkelten Stellen in Mauerwinkeln, an glatten Hauswänden und überhängenden Dachtraufen. Jungtiere leben am Boden. Diese Art verfüg…

First Record of the Genus Acanthixalus Laurent, 1944 from the Upper Guinean Rain Forest, West Africa, with the Description of a New Species

2003

Abstract We describe a new species of Acanthixalus from southwestern Ivory Coast. Acanthixalus sonjae sp. nov. differs from the Central African Acanthixalus spinosus genetically by 4.6 % in the investigated 16S rRNA. Morphologically adult frogs are very similar to A. spinosus. Male A. sonjae have wider heads and probably smaller gular glands than A. spinosus. Tadpoles of A. sonjae differ by much longer tails. Acanthixalus sonjae males are apparently mute. The new species is semiaquatic and lives in large water-filled cavities of trees in secondary and primary rain forest. Tadpoles complete metamorphosis in three months. They are at least partly carnivorous.

Overcoming the crisis : the changing profile and trajectories of Latvian migrants

2016

The work was funded by the National Research Programme [grant number 5.2.4] and the Latvian Council of Sciences [grant number 514/2012]. Taking mobility between Latvia and Western Europe as an empirical lens, this analysis explores the complex relationship between spatial disparities in earning potential and migration. The very dramatic shifts in the economic and political context against which migration from Latvia has occurred over the period 2004-2012 make it an especially apposite focus of research investigating the link between mobility and labour market circumstances. As an analytical starting point, conventional economic theory broadly explains the movement of workers from lower to h…

Finnish vocational education and training in comparison: Strengths and weaknesses

2014

International journal for research in vocational education and training 1 (2014) 2, S. 81-106

Twenty Years of Basic Vocational Education Provision in Spain: Changes and Trends

2015

International journal for research in vocational education and training 2 (2015) 2, S. 137-151