Search results for "Wester"
showing 10 items of 1157 documents
The Harvesting Memories Project: Landscape Archaeology in the Castro/Giardinello Valley and Mt. Barraù (Corleone, Palermo)
2018
Il progetto Harvesting Memories è finalizzato allo studio delle interazioni tra dinamiche umane e fattori ecologici che nella lunga durata hanno contribuito alla formazione dei paesaggi rurali. L’area di studio è localizzata tra Corleone e Campofiorito (Palermo) nei pressi delle contrade Castro e Giardinello e lungo le pendici occidentali di Monte Barrù. Questo distretto dell’Alto Belice Corleonese ha rappresentato un asse di collegamento tra la costa meridionale della Sicilia e quella settentrionale fin all’epoca repubblicana con continuità anche nel Medioevo in cui è citato per la prima volta il toponimo Barraù/Barracù, dal nome arabo ra’s e ǧabal bū ‘r-raḫū, nella Jarida di Monreale del …
Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavage.
2009
The topoisomerase I inhibitor topotecan (TPT) is used in the therapy of different tumors including high-grade gliomas. We previously showed that TPT-induced apoptosis depends on p53 with p53 wild-type (wt) cells being more resistant because of p53-controlled degradation of topoisomerase I. Here, we show that p53-deficient (p53(-/-)) fibroblasts undergo excessive mitochondrial apoptosis featuring H2AX phosphorylation, Bcl-x(L) decline, cytochrome c release, caspase-9/-3/-2 activation, and cleavage of Bid. In wt and apaf-1(-/-) cells, caspase-2 did not become activated and Bid was not cleaved. In addition, p53(-/-) cells cotreated with TPT and caspase-3 inhibitor showed neither caspase-2 acti…
Le groupe Kering ouvre la voie à la comptabilité environnementale
2015
National audience
A Dominant Global Translation Strategy in Thai Translated Novels: The Translations of Religious Markers in Dan Brown’s Thriller Novels
2020
When translation is considered as an integral part of larger social systems (Even-Zohar 1990), the ways in which translations are produced to serve readers’ specificity could be affected. This paper examines whether there is a preference for a specific global translation strategy due to a readership that is specialized in terms of education level. Adopting Venuti’s (1995/2008) division of global translation strategies into exoticizing and domesticating translation, it examines the frequency of local translation strategies, which are part of a global translation strategy, used in translating English-Thai religious markers in Dan Brown’s Angels and Demons, The Da Vinci Code, The Lost Symbol, …
Concepts and Concept Formation in Early Modern Philosophy
2013
The Renaissance witnessed a revival of ancient and Arabic philosophical traditions, such as Platonism, Skepticism and Averroism. Renaissance syncretism was especially influential at the universities in Northern Italy, where several scholars reinterpreted Medieval Latin conceptions of intelligible species. In the sixteenth and seventeenth century, university teaching in most European universities was dominated by second scholasticism. Francisco Suarez was the most philosophically inventive, as well as most influential, among these early modern scholastics (1).
Mapping and expression pattern analysis of key components of the major histocompatibility complex class I antigen processing and presentation pathway…
2001
Renal cell carcinoma (RCC) represent approximately 5% of all cancer deaths. At the time of presentation, over 50% of the patients have already developed locally advanced or metastatic disease with five-year survival rates of less than 20%. Although relative resistant to conventional regimens, RCC are partially susceptible to T cell-based immunotherapy. To further develop this treatment modality, two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) was applied for both the mapping of the key components of the major histocompatibility complex (MHC) class I antigen processing and presentation machinery (APM) and the characterization of the constitutive and cytokine-regulated protein e…
Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent syna…
2013
A major goal in current neuroscience is to understand the causal links connecting protein functions, neural activity, and behavior. The cannabinoid CB1 receptor is expressed in different neuronal subpopulations, and is engaged in fine-tuning excitatory and inhibitory neurotransmission. Studies using conditional knock-out mice revealed necessary roles of CB1 receptor expressed in dorsal telencephalic glutamatergic neurons in synaptic plasticity and behavior, but whether this expression is also sufficient for brain functions is still to be determined. We applied a genetic strategy to reconstitute full wild-type CB1 receptor functions exclusively in dorsal telencephalic glutamatergic neurons a…
Glutathione regulates telomerase activity in 3T3 fibroblasts.
2004
Changes in telomerase activity have been associated either with cancer, when activity is increased, or with cell cycle arrest when it is decreased. We report that glutathione, a physiological antioxidant present at high intracellular concentrations, regulates telomerase activity in cells in culture. Telomerase activity increases in 3T3 fibroblasts before exponential cell growth. The peak of telomerase activity takes place 24 h after plating and coincides with the maximum levels of glutathione in the cells. When cells are treated with buthionine sulfoximine, which decreases glutathione levels in cells, telomerase activity decreases by 60%, and cell growth is delayed. Glutathione depletion in…
Roads, travelling and communication in the Polish – Lithuanian Commonwealth in the 18th century. Russian and West European visitors’ perspective
2020
W artykule przedstawiony został stan techniczny dróg lądowych i rzecznych, mostów, grobli oraz pozostałej infrastruktury komunikacyjnej w Polsce na podstawie relacji podróżników z zagranicy, w tym Rosjan. Stan oraz jakość lądowych i rzecznych środków transportu był oceniany przez cudzoziemców bardzo nisko, podobnie jak jakość usług oferowanych w przydrożnych karczmach w Polsce i na Litwie. W rezultacie podróżowanie w XVIII w. po Rzeczypospolitej mogło stanowić interesujące doświadczenie. Tak goście z Rosji, jak i z krajów zachodniej Europy natrafiali na wiele przeszkód w trakcie podróży, postrzegając przy tym kraj jako pełen paradoksów. Fatalny stan dróg, przerażające swoim standardem karcz…
Latvijas Vēstures Institūta Žurnāls, 2022, Speciālizlaidums (116)
2022
Speciālizlaidums sagatavots Valsts pētījumu programmas projekta “Indivīda, sabiedrības un valsts mijiedarbība kopējā Latvijas vēstures procesā: vērtību konflikti un kopīgu vērtību veidošanās vēsturiskos lūzumu punktos / Interaction between the individual, the society and the state in process of the history of Latvia: Conflicting values and formation of shared values during historical turning points” (Nr. VPP-IZM-2018/1-0018) ietvaros (vad. G. Zemītis)