Search results for "Wissenschaft"
showing 10 items of 426 documents
SANS (USH1G) Molecularly Links the Human Usher Syndrome Protein Network to the Intraflagellar Transport Module by Direct Binding to IFT-B Proteins.
2019
The human Usher syndrome (USH) is a retinal ciliopathy, characterized by profound congenital deafness, variable vestibular dysfunction and pre-pubertal onset of retinitis pigmentosa. In the effected sensory cells, USH protein networks are assumed to function in ciliary transport processes. The USH1G protein SANS is a scaffold of the ciliary/periciliary USH protein network of photoreceptor cells. Moreover, SANS is associated with microtubules, the transport routes for protein delivery toward the cilium. To enlighten the role of SANS in ciliary transport processes, we aimed to identify transport related proteins associated with SANS. The intraflagellar transport (IFT) system is a conserved me…
Training the translator trainers : an introduction
2019
This is an Accepted Manuscript of an article published by Taylor & Francis in [The Interpreter and Translator Trainer] on [09 Oct 2019], available online: http://www.tandfonline.com/10.1080/1750399X.2019.1647821
"In der Mathematik ist ein Streit mit Sicherheit zu entscheiden". Perspektiven einer Soziologie der Mathematik
2000
Die Mathematik wird in diesem Aufsatz als ein empirisches Beispiel präsentiert, an dem sich die Voraussetzungen eines "rationalen Dissenses" exemplarisch untersuchen lassen. Denn im Gegensatz zu anderen epistemischen Kulturen gibt es in der Mathematik weder interpretative Flexibilität noch unentscheidbare Kontroversen. Auf der Basis einer medientheoretischen Perspektive und einer Feldstudie in einem internationalen Mathematikinstitut geht der Aufsatz der Frage nach, ob die Soziologie im Falle der Mathematik nicht auf eine prinzipielle Grenze stößt. In einem ersten Teil wird die These einer epistemischen Besonderheit der Mathematik präzisiert und in Auseinandersetzung mit zwei programmatisch…
Microwear textures associated with experimental near-natural diets suggest that seeds and hard insect body parts cause high enamel surface complexity…
2022
In mammals, complex dental microwear textures (DMT) representing differently sized and shaped enamel lesions overlaying each other have traditionally been associated with the seeds and kernels in frugivorous diets, as well as with sclerotized insect cuticles. Recently, this notion has been challenged by field observations as well as in vitro experimental data. It remains unclear to what extent each food item contributes to the complexity level and is reflected by the surface texture of the respective tooth position along the molar tooth row. To clarify the potential of seeds and other abrasive dietary items to cause complex microwear textures, we conducted a controlled feeding experiment wi…
Satellite Observations of the Contrasting Response of Trees and Grasses to Variations in Water Availability
2019
Interannual variations in ecosystem primary productivity are dominated by water availability. Until recently, characterizing the photosynthetic response of different ecosystems to soil moisture anomalies was hampered by observational limitations. Here, we use a number of satellite-based proxies for productivity, including spectral indices, sun-induced chlorophyll fluorescence, and data-driven estimates of gross primary production, to reevaluate the relationship between terrestrial photosynthesis and water. In contrast to nonwoody vegetation, we find a resilience of forested ecosystems to reduced soil moisture. Sun-induced chlorophyll fluorescence and data-driven gross primary production ind…
ARIA���EAACI statement on asthma and COVID���19 (June 2, 2020)
2021
Artículo con numerosos autores sólo se mencionan el primero y el de la UAM
Patterns of structural and sequential ambidexterity in cross-border media management
2019
ABSTRACT Organisational ambidexterity – the ability of a company to successfully link exploitation and exploration – is a fruitful approach for cross-border management. It is a crucial concept for media companies that, because of the dual (cultural and economic) character of their products, need to reconcile strategies of mere expansion with local customisation when engaging across borders. Drawing on semi-structured interviews with international media managers, this article captures patterns of ambidextrous strategising and organising in cross-border media activities. The article focuses on digitisation, which has altered the opportunities for balancing exploration and exploitation in inte…
Nanomechanics of individual aerographite tetrapods
2017
Carbon-based three-dimensional aerographite networks, built from interconnected hollow tubular tetrapods of multilayer graphene, are ultra-lightweight materials recently discovered and ideal for advanced multifunctional applications. In order to predict the bulk mechanical behaviour of networks it is very important to understand the mechanics of their individual building blocks. Here we characterize the mechanical response of single aerographite tetrapods via in situ scanning electron and atomic force microscopy measurements. To understand the acquired results, which show that the overall behaviour of the tetrapod is governed by the buckling of the central joint, a mechanical nonlinear mode…
The infrastructure MESSy submodels GRID (v1.0) and IMPORT (v1.0)
2018
The coupling of Earth system model components, which work on different grids, into an Earth System Model (ESM) provokes the necessity to transfer data from one grid to another. Additionally, each of these model components might require data import onto its specific grid. Usually, one of two approaches is used: Either all input data is preprocessed to the employed grid, or the imported data is interpolated on-line, i.e. during model integration to the required grid. For the former, each change in the model resolution requires the re-preprocessing of all data. The latter option implies that in each model integration computing time is required for the grid mapping. If all components of an ESM …
Focal Cortical Lesions Induce Bidirectional Changes in the Excitability of Fast Spiking and Non Fast Spiking Cortical Interneurons
2014
A physiological brain function requires neuronal networks to operate within a well-defined range of activity. Indeed, alterations in neuronal excitability have been associated with several pathological conditions, ranging from epilepsy to neuropsychiatric disorders. Changes in inhibitory transmission are known to play a key role in the development of hyperexcitability. However it is largely unknown whether specific interneuronal subpopulations contribute differentially to such pathological condition. In the present study we investigated functional alterations of inhibitory interneurons embedded in a hyperexcitable cortical circuit at the border of chronically induced focal lesions in mouse …