Search results for "cause"
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Sensory analysis integrated by palynological and physicochemical determinations plays a key role in differentiating unifloral honeys of similar botan…
2015
Summary Myrtaceae honeys produced in Sierra Morena (southern Spain, Andalusia) are obtained from both Eucalyptus camaldulensis and Myrtus communis, and honeys can be easily confused when classified as they come from the same botanical family. The characterisation was intended on the basis of their physicochemical, sensory and palynological properties. Cluster analysis (CA) and principal component analysis (PCA) allowed us to make a distinction between two honey profiles. The first one corresponds to the European sensory profile described for Eucalyptus unifloral honeys. The second profile, which sensory characteristics are absolutely different, has not been previously described. Classificat…
Profilaktyka i terapia fonoholizmu wśród uczniów szkół podstawowych
2020
Wobec nasilającego się zjawiska fonoholizmu wśród dzieci i młodzieży szczególnego znaczenia nabierają obecnie działania związane z profilaktyką i terapią tego typu zaburzeń. Istotne w nich role mają do odegrania nauczyciele, a także, co oczywiste, rodzice. Ich wysiłki jednak będą skuteczne dopiero wtedy, gdy opanują oni wiedzę dotyczącą mechanizmów powstawania omawianych patologii, zrozumieją cele i zadania, jakie się w tej kwestii przed nimi stawia, sami zaprezentują wartościowe wzorce postępowania. Materiał przytoczony w artykule (w tym wyniki badań sondażowych, przeprowadzonych w grupie rodziców uczniów szkół podstawowych) świadczy o tym, że ani jedni, ani drudzy nie do końca odpowiednio…
Attività extralavorativa durante la malattia: obblighi del lavoratore e contestazione disciplinare
2021
Il contributo analizza una recente pronuncia della Suprema Corte. La sentenza in esame affronta la questione dello svolgimento di attività lavorativa presso terzi da parte del dipendente assente per malattia e si allinea al consolidato orientamento secondo il quale, pur non sussistendo un divieto assoluto di effettuare altra attività durante il periodo di sospensione del rapporto di lavoro, è legittimo il recesso del datore di lavoro quando questa configuri la violazione degli specifici obblighi contrattuali di diligenza e fedeltà, nonché dei doveri generali di correttezza e buona fede. The note analyses a recent judgment of the Supreme Court of Cassation. The decision deals with the work d…
Parentyfikacja w rodzinie w doświadczeniach młodych dorosłych
2017
Rodzina stanowiąca naturalne środowisko wychowawcze dla młodego pokolenia, nie zawsze prawidłowo wywiązuje się z ról i zadań wychowawczych. Zdarzenia losowe, dysfunkcje powodują, iż role te zostają odwrócone, tj. dzieci przejmują zadania dorosłych. Określa się to terminem parentyfikacja. Celem podjętych badań było poznanie przeżywanych w okresie dzieciństwa doświadczeń związanych z parentyfikacją z perspektywy młodych dorosłych. Zostały one przeprowadzone wśród studentów Uniwersytetu Opolskiego, a wzięło w nich udział 300 osób. Respondenci doświadczający inwersji ról w rodzinach stają się silniejsi, odpowiedzialni, zaradni, zdobywają przydatne w życiu umiejętności. Przez całe życie nadmiern…
Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis.
2005
Objective— Sedentary lifestyle is associated with increased cardiovascular events. The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase. Methods and Results— C57BL6 mice were subjected to regular housing (physical inactivity) or voluntary training on running wheels (6 weeks). Inactivity increased vascular lipid peroxidation to 148±9% and upregulated superoxide release to 176±17% (L-012 chemiluminescence) and 188±29% (cytochrome C reduction assay), respectively. ROS production was predominantly increased in the endothelium and the medi…
La desheredación del menor de edad
2021
This work aims to answer the eternal question of the disinheritance of the child under legal age. To this end, we will approach the institute of disinheritance, its foundation and its jurisprudential evolution. We will also address the capacity and responsibility of the child under legal age and the emancipated minor. Subsequently, we will carry out the study of the disinheritance of the child under legal age, subject to the whim of the specific disinherited causes, since each of the causes provided for in art. 853 Spanish Civil Code are endowed with their own idiosyncrasy, being very complicated, if not impossible, to deal with the subject of this work apart from the vicissitudes that can …
Mariano Benlliure Gil, artífice de la recuperación del patrimonio escultórico para la Cofradía California de Cartagena
2020
After the patrimonial destruction that took place during the Civil War of 1936-1939 in the city of Cartagena, religious art and especially sacred sculpture, is greatly affected. The artistic expressions that the Passionist entities took to the streets on the days of Holy Week, disappear almost in their entirety, having to start a tremendously costly reconstruction process in order to alleviate the losses suffered. The Cofradía California commissioned the renovation of its sculptural patrimony heritage, which came to replace the wealth of the works of Salzillo, to the Valencian artist Mariano Benlliure Gil. All this process is the one studied in this article, keeping in mind the different bi…
Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin s…
1994
Cytotoxic necrotizing factor type 2 (CNF2) produced by Escherichia coli strains isolated from intestinal and extraintestinal infections is a dermonecrotic toxin of 110 kDa. We cloned the CNF2 gene from a large plasmid carried by an Escherichia coli strain isolated from a lamb with septicemia. Hydropathy analysis of the deduced amino acid sequence revealed a largely hydrophilic protein with two potential hydrophobic transmembrane domains. The N-terminal half of CNF2 showed striking homology (27% identity and 80% conserved residues) to the N-terminal portion of Pasteurella multocida toxin. Methylamine protection experiments and immunofluorescence studies suggested that CNF2 enters the cytosol…
Rho GTPases are over-expressed in human tumors.
1999
Small GTPases of the Rho family are involved in the regulation of a variety of cellular processes, such as the organization of the microfilamental network, cell-cell contact and malignant transformation. To address the question of whether Rho proteins are involved in carcinogenesis in man, we compared their expression in tumors from colon, breast and lung with that of the corresponding normal tissue originating from the same patient. As shown by Rho-specific 32P-ADP-ribosylation, as well as Western-blot analysis, the amount of RhoA protein was largely increased in all 3 types of tumors tested. The most dramatic differences in the expression of Rho GTPases were observed in breast tissue. All…
Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O
2001
The pore-forming toxin streptolysin O (SLO) can be used to reversibly permeabilize adherent and nonadherent cells, allowing delivery of molecules with up to 100 kDa mass to the cytosol. Using FITC-labeled albumin, 10 5 –10 6 molecules were estimated to be entrapped per cell. Repair of toxin lesions depended on Ca 2+ -calmodulin and on intact microtubules, but was not sensitive to actin disruption or to inhibition of protein synthesis. Resealed cells were viable for days and retained the capacity to endocytose and to proliferate. The active domains of large clostridial toxins were introduced into three different cell lines. The domains were derived from Clostridium difficile B-toxin and Clo…