Search results for "cept"
showing 10 items of 15508 documents
Bcl-xL as a Modulator of Senescence and Aging
2021
Many features of aging result from the incapacity of cells to adapt to stress conditions. When cells are overwhelmed by stress, they can undergo senescence to avoid unrestricted growth of damaged cells. Recent findings have proven that cellular senescence is more than that. A specific grade of senescence promotes embryo development, tissue remodeling and wound healing. However, constant stresses and a weakening immune system can lead to senescence chronicity with aging. The accumulation of senescent cells is directly related to tissue dysfunction and age-related pathologies. Centenarians, the most aged individuals, should accumulate senescent cells and suffer from their deleterious effects,…
An integrative dual-route model of rhythm perception and production
2009
An integrative dual-route model of rhythm perception and production is proposed here. Furthermore, an empirical study illustrated in the second part of this paper provides evidence of the existence of two different cognitive pathways. The development of the model is based on fundamental psychological principles of perception, action control and relevant neurobiological findings in rhythm processing and sensorimotor synchronization. Experiments with a dual-task paradigm were used during synchronization tapping to verify the fundamental assumptions of the model. The aim was to examine whether professional drummers show a change in tapping performance when their attention is drawn to another t…
Mucin 1 deficiency mediates corticosteroid insensitivity in asthma
2019
BACKGROUND: The loss of corticosteroid efficacy is an important issue in severe asthma management and may lead to poor asthma control and deterioration of airflow. Recent data indicate that Mucin 1 (MUC1) membrane mucin can mediate corticosteroid efficacy in chronic rhinosinusitis, but the role of MUC1 in uncontrolled severe asthma is unknown. The objective was to analyze the previously unexplored role of MUC1 on corticosteroid efficacy in asthma. METHODS: Mucin 1 expression was evaluated by real-time PCR in human bronchial epithelial cells (HBEC) and blood neutrophils from uncontrolled severe asthma (n=27), controlled mild asthma (n=16), and healthy subjects (n=13). IL-8, MMP9, and GM-CSF …
Principals’ perceptions about collective competences in shared leadership contexts
2022
This article aims to understand how principals perceive collective competences in their schools’ shared leadership contexts. Collective competences are crucial in shared leadership but have not been widely explored within educational leadership studies. This study investigates collective competences through two intersected models: attribute and relational models. The data comprise interviews conducted with 12 Finnish principals in comprehensive and secondary schools who practiced shared modes of leadership. Due to the Finnish school culture emphasising collaboration, the principals were expected to be able to broadly consider the collective side of competences in their schools. The data wer…
Identification of new ligands for sigma receptors. Design and synthesis of a beta-aminoketonic drug discovery library
2009
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
2013
Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborat…
Realitātes reprezentācijas principi Kristofera Nolana kinofilmā "Inception"
2017
Bakalaura darba tēma - Realitātes reprezentācijas principi Kristofera Nolana kinofilmā “Inception”. Darba mērķis ir izpētīt realitātes reprezentācijas paņēmienus un realitātes koncepciju K. Nolana kinofilmā “Inception”. Darba ietvaros tika analizēta kinofilma “ Pirmsākums”. Darba pirmā daļa ir teorētiskā daļa, kas iekļauj sevī informāciju par kino izteiksmes līdzekļiem, naratīva konstrukcijas principiem, laiku un telpu kinofilmās. Otrā daļa ir veltīta pētniecības metodēm – naratīvai un semiotiskai analīzei. Trešajā daļā ir veikta semiotiskā analīze, tika analizēti filmas varoņi, simboli, kas parādās filmas gaitā un naratīva filmas analīze, ar kuras palīdzību tika analizēta filmas naratīva s…
L'image, l'analogon, le simulacre : la question des 'fictions perceptives' chez Husserl
2006
Emetteur, récepteur et simulacre : questions d'affiches publicitaires
2014
This paper analyzes the concepts of simulacrum, adresser and adressee in the field of advertising. The latter is discussed in a semiotic and linguistic perspective. Inspired by the concept of semiosphere and other sociological perspectives, we study the simulacrum and its representation in the advertising discourse. To do so, we had to take into account the adressee of the advertising messages through intentionality and subjectivity issues, or, in other words, through the questions of interpretation.
Revista electrónica de investigación y evaluación educativa
2016
El Programa para la Evaluación Internacional de Alumnos (PISA) proporciona un marco en el que más de 80 países colaboran para construir métricas globales avanzadas para explorar los conocimientos, habilidades y atributos del estudiantado. El diseño de las evaluaciones plantea importantes desafíos conceptuales y técnicos, como el éxito del aprendizaje. Más allá de una base conceptual sólida, PISA necesita cumplir una serie de exigencias a veces contradictorios. Los/as administradores de escuelas, autoridades normativas y los docentes deben ser capaces de utilizar esta información de la evaluación para determinar cómo crear mejores oportunidades para el aprendizaje de los estudiantes. Las eva…