Search results for "channel"
showing 10 items of 1643 documents
AMPA Receptor Auxiliary Proteins of the CKAMP Family
2019
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are assembled of four core subunits and several additional interacting proteins. Cystine-knot AMPA receptor-modulating proteins (CKAMPs) constitute a family of four proteins that influence the trafficking, subcellular localization and function of AMPA receptors. The four CKAMP family members CKAMP39/shisa8, CKAMP44/shisa9, CKAMP52/shisa6 and CKAMP59/shisa7 differ in their expression profile and their modulatory influence on AMPA receptor function. In this review, I report about recent findings on the differential roles of CKAMP family members.
Flow kinematic characteristics in the scour hole downstream of a grade-control structure
2010
Digitization of the communication and its implications for marketing
2014
Performance of the cost-effective Planacon ® MCP-PMTs in strong magnetic fields
2020
We present the behavior of the cost-effective Planacon MCP-PMTs with pore diameter in the presence of axial magnetic fields up to 0.5 T. Having a batch of 62 devices of the same type, two MCP-PMTs were selected and their gain variation measured in different magnetic fields. These two otherwise identical devices satisfied the selection criteria by requiring the lowest (1.15 kV) and one of the highest (1.4 kV) bias voltage values to achieve a given gain. Both MCP-PMTs have a nearly identical tolerance of the strong magnetic field despite the significant difference in the bias voltage. This clarifies the mechanism of the B-field influence on the MCP-PMT gain, emphasizing the importance of the …
Stromal Interaction Molecule 1 (STIM1) Is Involved in the Regulation of Mitochondrial Shape and Bioenergetics and Plays a Role in Oxidative Stress
2012
Calcium ions are involved in a plethora of cellular functions including cell death and mitochondrial energy metabolism. Store-operated Ca(2+) entry over the plasma membrane is activated by depletion of intracellular Ca(2+) stores and is mediated by the sensor STIM1 and the channel ORAI1. We compared cell death susceptibility to oxidative stress in STIM1 knock-out and ORAI1 knockdown mouse embryonic fibroblasts and in knock-out cells with reconstituted wild type and dominant active STIM1. We show that STIM1 and ORAI1 deficiency renders cells more susceptible to oxidative stress, which can be rescued by STIM1 and ORAI1 overexpression. STIM1 knock-out mitochondria are tubular, have a higher Ca…
Molecular basis of early epithelial response to streptococcal exotoxin: role of STIM1 and Orai1 proteins
2011
Streptolysin O (SLO) is a cholesterol-dependent cytolysin (CDC) from Streptococcus pyogenes. SLO induces diverse types of Ca(2+) signalling in host cells which play a key role in membrane repair and cell fate determination. The mechanisms behind SLO-induced Ca(2+) signalling remain poorly understood. Here, we show that in NCI-H441 cells, wild-type SLO as well as non-pore-forming mutant induces long-lasting intracellular Ca(2+) oscillations via IP(3) -mediated depletion of intracellular stores and activation of store-operated Ca(2+) (SOC) entry. SLO-induced activation of SOC entry was confirmed by Ca(2+) add-back experiments, pharmacologically and by overexpression as well as silencing of ST…
Glucose excites hypothalamic neurons through the activation of Transient Receptor Potential Canonical (TRPC) channels
2015
International audience
Analytical solutions of magnetohydrodynamical problems on a flow of conducting fluid in the entrance region of channels in a strong magnetic field šķ…
2014
Darbā iegūti analītiskie atrisinājumi magnetohidrodinamiskiem (MHD) uzdevumiem par elektrovadoša šķidruma plūsmu plakanā un cilindriskā kanālā stiprā magnētiskā laukā gadījumiem, kad šķidrums ietek kanālos caur galīga platuma spraugu vai caur galīga rādiusa atveri kanāla sānu malā. Pamatojoties uz iegūtajiem atrisinājumiem, veikta plūsmas ātruma lauka skaitliskā analīze. Iegūti uzdevumu asimptotiskie atrisinājumi lieliem Hartmana skaitļiem. Turklāt darbā pētīta pilna spiediena spēka šķidruma ieplūdes apgabalā atkarība no funkcijas veida, ar kuru ir uzdots ātruma robežnosacījums. Pētījums veikts analītiski, risinot divas hidrodinamiskas problēmas un divas MHD problēmas par viskoza šķidruma i…
Exclusive measurement of quasi-free η-photoproduction from deuterium
2003
Quasi-free photoproduction of eta-mesons from the deuteron has been measured at the tagged photon facility of the Mainz microtron MAMI with the photon spectrometer TAPS for incident photon energies from the production threshold at 630 MeV up to 820 MeV. In a fully exclusive measurement eta-mesons and recoil nucleons were detected in coincidence. At incident photon energies above the production threshold on the free nucleon, where final state interaction effects are negligible, an almost constant ratio of sigma(n)/sigma(p)=0.66+/-0.10 was found. At lower incident photon energies the ratio rises due to re-scattering effects. The average ratio agrees with the value extracted from a comparison …
Management du consommateur multicanal : Importance de l’intégration perçue de la gestion de la fidélité
2013
La gestion de la fidélité constitue l’une des préoccupations majeures des managers des enseignes multicanal. Comment retenir mes clients multicanal ? Et comment convertir mes shoppers multicanal en clients multicanal ? Telles sont les questions auxquelles ce papier vise à répondre, à travers une étude quantitative auprès de 343 consommateurs multicanal. Les résultats montrent un impact significatif de l’intégration perçue de la gestion de la fidélité sur la confiance dans l’enseigne multicanal et sur les comportements multicanal. Ils montrent également le rôle de l’intégration perçue de la gestion de la fidélité dans le management des consommateurs multicanal. Managing loyalty is one of the…