Search results for "clinica"

Behavioral Inhibition Underlies the Link Between Interoceptive Sensitivity and Anxiety-Related Temperamental Traits

2017

Interoceptive sensitivity is a biologically determined, constitutional trait of an individual. High interoceptive sensitivity has been often associated with proneness to anxiety. This association has been explained by elevated autonomic responsiveness in anxious individuals. However, in a heartbeat discrimination task (discrimination of heartbeats’ simultaneity to an external stimulus) low cardiac responsiveness has accompanied enhanced performance. The relation between these factors seems task dependent, and cannot comprehensively explain the link between interoceptive sensitivity and anxiety. We explored for additional explanatory factors for this link. More specifically, we studied which…

Physiological and autonomic stress responses after prolonged sleep restriction and subsequent recovery sleep in healthy young men

2018

Purpose Sleep restriction is increasingly common and associated with the development of health problems. We investigated how the neuroendocrine stress systems respond to prolonged sleep restriction and subsequent recovery sleep in healthy young men. Methods After two baseline (BL) nights of 8 h time in bed (TIB), TIB was restricted to 4 h per night for five nights (sleep restriction, SR, n = 15), followed by three recovery nights (REC) of 8 h TIB, representing a busy workweek and a recovery weekend. The control group (n = 8) had 8 h TIB throughout the experiment. A variety of autonomic cardiovascular parameters, together with salivary neuropeptide Y (NPY) and cortisol levels, were assessed.…

Etude de l'impact du contrôle postural associé au port de verres prismatiques dans la réduction des troubles cognitifs chez le dyslexique de développ…

2007

But de l’etude L’objectif de ce travail est d’evaluer l’impact des modifications proprioceptives induites par un traitement postural sur les troubles cognitifs d’une population d’enfants souffrant de dyslexie de developpement. Patients et methodes Il a ete constitue un groupe de 20 enfants dyslexiques traites par prismes posturaux, semelles « de posture » et reeducation posturale, et un groupe temoin de 13 enfants dyslexiques portant uniquement des lunettes sans prismes. Tous les enfants etaient de sexe masculin. Lors de leur inclusion dans l’etude (M0) et 6 mois plus tard (M6), tous les participants ont ete evalues par un bilan ophtalmologique et postural et ont recu un examen neuropsychol…

Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies

2019

The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone. peerReviewed

A System Dynamics approach to improve clinical risk management effectiveness in an italian hospital ward: a case study.

'REOFUT' as an Observation Tool for Tactical Analysis on Offensive Performance in Soccer: Mixed Method Perspective

2019

Performance analysis in complex sports like soccer requires the study of the influence of the interaction between both teams during the game on final performance. The mixed methods approach involves the collection, analysis, and interpretation of qualitative and quantitative data for the same purpose and within the framework of the same study. To build certain observation tools, mixed methods are necessary in order to take advantage of integration between qualitative and quantitative elements. The aim of this study was to develop a new no standard observation tool to analyze soccer offensive performance considering not only the observed team but also some aspects of the opponent behavior, a…

Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018…

2018

Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean dia…

CERN IRRADIATION FACILITIES.

2017

CERN provides unique irradiation facilities for applications in dosimetry, metrology, intercomparison of radiation protection devices, benchmark of Monte Carlo codes and radiation damage studies to electronics.

Intensivsykepleierens vurdering og tilrettelegging av søvn : en kvalitativ studie om intensivsykepleierens erfaring med vurdering og tilrettelegging …

2016

Masteroppgave i spesialsykepleie – Universitetet i Agder 2016 Background: Previous studies have showed that lack of sleep makes ICU patients stressed. In addition, other studies have showed that the ICU nurses’ subjective assessment of ICU patients’ sleep have low correspondence with objective data, like polysomnography. This shows the need for further studies related to the assessment and facilitation of sleep that the ICU nurses are doing. Aim: The aim of this study is to investigate the ICU nurse’s experience of assessment and facilitation of the ICU patient’s sleep, and how sleep can affect the course of the disease. Method: The study has a qualitative approach and in-depth interviews w…

Dexamethasone premedication suppresses vaccine-induced immune responses against cancer

2020

ABSTRACT Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeutic cancer vaccine, which is based on a liposomal formulation of tumor-antigen encoding RNA (RNA-LPX) and induces a strong T-cell response both in mice as well as in humans. In this study, we investigated in vivo in mice and in human PBMCs the effect of the commonly used long-acting GCS Dexamethasone (Dexa) on the efficacy of this vaccine format, with a particular focus on antigen-specif…