Search results for "drug discovery"
showing 10 items of 3927 documents
Non-glycemic effects of pioglitazone and incretin-based therapies.
2013
Atherosclerosis and cardiovascular events are highly prevalent and represent the major cause of mortality in patients with type 2 diabetes. Therefore, there is significant interest in the non-glycemic properties of anti-diabetic agents, particularly on those that are effective on cardiovascular risk factors. Thiazolidinediones and incretin-based therapies (IBTs) represent some of the most recent treatment options approved for the management of type 2 diabetes; these agents have shown important glycemic effects, as well as a number of non-glycemic effects. The latter include those on body weight, inflammation, hypertension and dyslipidemia, thus impacting the different components of the meta…
Effects of l-Carnitine in Patients with Autism Spectrum Disorders: Review of Clinical Studies
2019
Carnitine is an amino acid derivative, which plays several important roles in human physiology, in the central nervous system, and for mitochondrial metabolism, in particular. Altered carnitine metabolic routes have been associated with a subgroup of patients with autism spectrum disorders (ASD) and could add to the pathophysiology associated with these disorders. We review the current evidence about the clinical effects of carnitine administration in ASD in both non-syndromic forms and ASD associated with genetic disorders. Two randomized clinical trials and one open-label prospective trial suggest that carnitine administration could be useful for treating symptoms in non-syndromic ASD. Th…
Gut Microbiota, Obesity and Bariatric Surgery: Current Knowledge and Future Perspectives.
2019
Background::There is an urgent need for a better understanding and management of obesity and obesity- associated diseases. It is known that obesity is associated with structural and functional changes in the microbiome.Methods::The purpose of this review is to present current evidence from animal and human studies, demonstrating the effects and the potential efficacy of microbiota modulation in improving obesity and associated metabolic dysfunctions.Results::This review discusses possible mechanisms linking gut microbiota dysbiosis and obesity, since there is a dual interaction between the two of them. Furthermore, comments on bariatric surgery, as a favourable model to understand the under…
Traditional Chinese medicine research in the post-genomic era: good practice, priorities, challenges and opportunities.
2012
Abstract Background and aims GP-TCM is the 1st EU-funded Coordination Action consortium dedicated to traditional Chinese medicine (TCM) research. This paper aims to summarise the objectives, structure and activities of the consortium and introduces the position of the consortium regarding good practice, priorities, challenges and opportunities in TCM research. Serving as the introductory paper for the GP-TCM Journal of Ethnopharmacology special issue, this paper describes the roadmap of this special issue and reports how the main outputs of the ten GP-TCM work packages are integrated, and have led to consortium-wide conclusions. Materials and methods Literature studies, opinion polls and di…
Der Anstieg einiger Serumenzyme (GOT, LDH, CPK, MK) nach Ganzk�rpermuskelmassage und seine Bedeutung bei Dermatomyositis
1972
25 gesunde Normalpersonen wiesen 8 Std nach einer Ganzkorpermuskelmassage einen signifikanten Aktivitatsanstieg der Serumenzyme GOT, LDH, CPK und MK auf, wobei die MK im pathologischen Bereich liegt (Durchschnittswerte vor Massage: GOT: 10,97 mE/ml, LDH: 154,78 mE/ml, CPK: 18,28 mE/ml, MK: 15,79 mE/1000 ml; Durchschnittswerte 8 Std nach Massage: GOT: 16,84 mE/ml, LDH: 179,82 mE/ml, CPK: 27,36 mE/ml, MK: 21,74 mE/1000 ml). Die diskutierten, moglichen Ursachen gebieten Zuruckhaltung mit Massagen und analogen medico-mechanischen Masnahmen bei Dermatomyositis.
The influence of dopamine on hemodynamics, microcirculation and renal function in patients with hypnotic drug intoxication
1976
The effect of dopamine on hemodynamics (CO, AoPm, TPR, SV, SW, CVP, PAPm, PAEDP), microcirculation (MBF, PS-product) and renal function (VU, CKI, CNa, CK, Cosm, TcH2O) was studied in 8 patients with hypnotic drug poisoning. With increasing doses of dopamine, cardiac output and heart rate increased and the peripheral resistance decreased. An augmentation of stroke volume and left ventricular stroke work was observed in the low dose range only (200--400 mug/min). With increasing doses, central venous pressure as well as mean pulmonary artery pressure and enddiastolic pulmonary artery pressure decreased. No vasoconstriction was found in muscle tissue vessels even with large doses of dopamine. …
A Review of the Cardiovascular and Anti-Atherogenic Effects of Ghrelin
2013
Ghrelin is a peptide hormone produced mainly in the stomach that has widespread tissue distribution and diverse hormonal, metabolic and cardiovascular activities. The circulating ghrelin concentration increases during fasting and decreases after food intake. Ghrelin secretion may thus be initiated by food intake and is possibly controlled by nutritional factors. Lean subjects have increased levels of circulating ghrelin compared with obese subjects. Recent reports show that low plasma ghrelin is associated with elevated fasting insulin levels, insulin resistance and type 2 diabetes mellitus. Factors involved in the regulation of ghrelin secretion have not yet been defined; however, it is as…
Untersuchungen zur Aktivit�tskinetik des Isoenzymes CK-MB im Serum nach Myokardinfarkt
1978
We investigated the activity kinetics of CK-total and CK-MB in 83 patients with proven myocardial infarctions. Serial serum samples were taken at intervals of 2--6 h. The activity of isoenzym CK-MB was determined by means of the immunological inhibition method. CK-MB activity was determined in all patients. The mean peak activity of CK-MB was 65 U/l (range: 9-241 U/l). At the time of peak CK-MB activity the mean percentage CK-MB activity was 13.2% (range: 3.4--21.7%). The CK-MB activity reached its peak at 17.4 h (range: 3.0--32.5 h) after the onset of retrosternal pain. This is 1.4 h after peak CK-total activity. The mean disappearance rate constant for CK-MB (n = 31) was found to be 9.3 X…
Bestimmung der Tagesschwankungen des Plasma-Testosterons normaler M�nner durch kompetitive Proteinbindung
1970
Bei der Bestimmung von Tagesschwankungen von Plasma-Testosteron normaler Manner mit der kompetitivenProteinbindung wurden tiefste Werte um 20.00 Uhr und hochste Werte entweder um 4.00 Uhr oder um 12.00 Uhr gefunden.
Angiotensin II-Stoffwechsel bei Angiotensininfusion und bei Kochsalzentzug
1975
1. Bei funf normotonen Probanden wurde im arteriellen und venosen Plasma des Unterarms vor und nach diatetischem Salzentzug sowie vor und wahrend Infusion von Angiotensin II-amid Angiotensin II (A II) und der Angiotensinmetabolit Angiotensin (3–8)-Hexapeptid (H) nach dunnschichtchromatographischer Trennung radioimmunologisch bestimmt.