Search results for "farmacologia"
showing 10 items of 411 documents
Drinking pattern matters: effects on maternal care and offspring vulnerability to alcohol in rats
2015
Alcohol drinking during pregnancy and post-partum period is a major concern because of the persistent neurobehavioral deficits in the offspring, which include increased vulnerability to substance abuse (1). The intermittent pattern of alcohol consumption induces higher drinking levels and deeper neurobiological changes in addiction-related brain regions, with respect to traditional free-access paradigms in male rats (2, 3). Nevertheless, no studies investigated on the effects of the drinking pattern on female subjects during pregnancy and perinatal time. To this aim, this study explored the consequences of continuous vs. intermittent drinking pattern on maternal behaviour and on offspring v…
STUDIO RETROSPETTIVO SULL’UTILIZZO DEGLI ANTIDEPRESSIVI NELLA PROVINCIA DI AGRIGENTO E ANALISI FARMACOECONOMICA NEL BIENNIO 2011–2012
La depressione è una patologia nevrotica che secondo le stime OMS nel 2020 sarà la seconda malattia ad alta prevalenza nel mondo, dopo le patologie cardiovascolari. Negli ultimi anni c'è stata un'esplosione sia per numero di nuovi casi che per intensità. Materiali e metodi. E’ stata condotta una analisi dei dati di consumo e di spesa attraverso il Progetto SFERA (Spesa- Farmaceutica-Elaborazioni-Regioni-ASL) e il sistema di rilevazione ottica ricette SSN nel periodo compreso tra gennaio/novembre per gli anni 2011 e 2012. I farmaci antidepressivi esaminati sono i seguenti, espressi in ATC 5. Per TCA di prima generazione: N06AA02, N06AA04, N06AA06, N06AA09, N06AA10. Per i TCA di seconda gener…
THE ROLE OF POLYMORPHISM OF TIOPURINE METHYLTRANSFERASE IN THERAPY WITH AZATHIOPRINE. PRELIMINARY STUDY
2017
Azathioprine is an immunosuppressive medication used in the treatment of inflammatory diseases (MICI). Despite its extensive use in therapy, azathioprine can result in serious side effects such as myelosuppression. The likelihood of developing myelosuppression also depends on genetic factors: one of the enzymes involved in drug metabolism, methyltransferase tiopurine (TPMT), is subject to genomic polymorphism. To date, 40 polymorphisms have been identified, of which three are associated with a reduction in enzymatic activity. These are TPMT*2, TPMT*3A and TPMT*3C polymorphisms. TPMT*1 is the wild-type coding form for an enzyme capable of efficiently metabolizing the drug. The objective of t…
BINGE DRINKING: CONSUMPTION PRACTICES AMONG YOUNG PEOPLE. ANALYSIS OF THE QUESTIONNAIRES COMPILED BY STUDENTS OF PALERMO CITY AND PROVINCE INVOLVED I…
2014
The term binge drinking is used in the northern countries of Europe, to point out the consumption of great intoxicating quantities of alcohol, until feel bad, for the pure and simple desire to get drunk. Conventionally, binge drinking is the consumption of at least six glasses of alcoholic drinks, different ones as well, in a single occasion and one after the other. A survey has been conducted through administration of questionnaires with the purpose to have an idea about the territorial diffusion of such practice among the students of Palermo and province. In the months of April and May 2014, this survey affected 30 classes of different schools in 10 cities and province, involving about 74…
AMOUNT OF ERBITUX USED IN THE HOSPITAL “CIVICO - DI CRISTINA - BENFRATELLI”, PALERMO
2017
Erbitux (Cetuximab) is indicated for the treatment of patients with epidermal growth factor receptor (EGFR)- expressing, KRAS wild-type metastatic colorectal cancer and without KRAS mutations (wild type). Cetuximab is a chimeric monoclonal IgG1 antibody directed against the EGFR. It blocks binding of endogenous EGFR ligands resulting in inhibition of the function of the receptor and induces the internalization of EGFR, which can lead to down-regulation of EGFR. Erbitux may be administered via a gravity drip, an infusion pump or a syringe pump. The first administration should be administered in 120 minutes and subsequent over 60 minutes. Precautions:It is stored at a temperature between 2°C …
Clindamycin-induced restless syndrome
2008
Brief description: We presented a case of severe RLS associated with clindamycin (a lincosamide antibiotic frequently used in clinical practice) which was also a cause of a neurological emergency unit admission
ANALISI DEI CONSUMI DI STUPEFACENTI E POPOLAZIONE DEL SERT DI TERMINI IMERESE FINALIZZATA ALL’ATTIVAZIONE DI UN PROGETTO EDUCAZIONALE
2013
Introduzione. In questo studio è stato preso in considerazione il consumo annuale di stupefacenti (metadone e buprenorfina) dal 2009 al 2012, da parte del Ser.T di Termini Imerese. Si è voluto indagare sulla tipologia di pazienti ambulatoriali per avviare un successivo progetto di prevenzione rivolto alle scuole. Materiali e metodi: I dati relativi ai consumi sono stati estrapolati dal programma di magazzino del polo di distribuzione di Termini Imerese, mentre i dati relativi ai pazienti sono stati ricavati dal Sistema Informativo Sanitario del Ministero della Salute consultabile dai dipendenti del Ser.T. Risultati: I consumi di metadone cloridrato flacone da 20 ml 0,1% sono progressivament…
ASSESSMENT OF HEAVY METAL CONTAMINATION IN TERRACES FOR PUBLIC USE RECOVERED IN THE CITY OF PALERMO AND IN AGRICULTURAL TERRACES
2017
The contamination by heavy metals in the soil is nowadays considered an indicator of environmental pollution caused by to several factors, such as waste disposal, industrial discharges and the use of irrigation water. Developed in collaboration with SO.GEST Ambiente Laboratory, in Palermo, this study had as a purpose to monitor the levels of heavy metals - Cd, Cr, Fe, Mn, Pb, Zn -both in public lands and in agricultural terrains. All the soil samples collected have been subjected to an acid extraction process by using HCL and eventually to a mass spectrometer-based analysis for the quantitative/ qualitative determination, specifically by the technique of flame atomic absorption spectrophoto…
ELABORATION OF CURCUMIN INTO DIKETONE MODIFIED ANALOGUES DEVOID OF NUCLEOPHILIC ADDITION CAPABILITY; IMPLICATIONS FOR THEIR ANTITUMOR AND CHEMOSENSIT…
2009
Curcumin (CUR), a polyphenolic compound extracted from Curcuma longa L.,can beconsidered as a good lead compound for the design of new drugs for the treatment of cancer and other therapeutic purposes. CUR is endowed with a diketone function, which appears to be important for its antitumor activity: also depending on the dose, the compound may show complex either pro-oxidant or anti-oxidant effects, which both may, at least in part, be linked to this structural moiety. In the lower concentration, "chemopreventive", range, CUR behaves mainly as an antioxidant; at higher concentrations, the a, b-unsaturated 1,3-diketone, as a Michael acceptor, can form adducts with the –SH groups and generate …