Search results for "fluid"

Simultaneous dissolution profiles of two drugs in pharmaceutical formulations by an FIA manifold

2002

Abstract This article deals with the simultaneous determination of dissolution profiles of two drugs with overlapped spectra, present in the same pharmaceutical formulation. The official procedure for the dissolution profile is adapted to the continuous-flow methodology; the dissolution vessel is connected to an FIA manifold, in which the sample aliquots from the dissolution vessel are treated in order to adjust to the suitable pH and dilution degree to be monitored. The resulting solution is injected into the carrier stream, an acetic acid–acetate buffer at pH 4.3 and forced to the flow-cell of the spectrophotometer. The simultaneous determination of both profiles is based on the first der…

Supercritical CO2 extraction of essential oils from orange peel

1996

The supercritical fluid extraction of orange essential oil was studied using dehydrated orange peel (0.0538 kg H2O kg−1 dm) from naveline cultivars as raw material and CO2 as solvent. The effect of operation conditions was analyzed in a series of experiments at 313 and 323 K and pressures between 1 and 25 MPa. Furthermore, the effect of CO2 flow rate and particle size of orange peel was studied in the range of 0.5 to 3.5 kg h−1 and 0.1 to 10 mm. The subcritical CO2 dissolves hardly any essential oils, however, on reaching the critical point, the amount of essential oils dissolved increased with pressure, within the range of pressures considered in this study. Increasing solvent mass flow de…

Gas assisted mechanical expression (GAME) as a promising technology for oil and phenolic compound recovery from tiger nuts

2015

Abstract The aim of this work was to investigate the potential of gas assisted mechanical expression (GAME) process as an innovative technology for oil extraction and polyphenol recovery from tiger nuts. GAME process was first studied by varying the supercritical carbon dioxide (SC-CO2) and the mechanical expression (ME) pressures (10–30 MPa), then was compared to separate processes applied alone, using either SC-CO2 or ME. The results showed that the better conditions for GAME were found using 20 MPa for SC-CO2 and 30 MPa for ME. Under these conditions, 50% of oil was released from tiger nuts after 10 min extraction, compared to only 10% and 20% when using SC-CO2 and ME separately at 20 an…

Supercritical Fluid Adsorption of Domperidone on Silica Aerogel

2013

Silica aerogel (SA) was loaded with domperidone to demonstrate the potentiality of adsorption processes based on the usage of supercritical carbon dioxide to treat poorly water-soluble drugs, forming new kinds of drug delivery systems. The effects of pressure, temperature and solution concentration on loaded SA were studied. Adsorption isotherms were measured at 35℃ and 45℃ and fitted with Langmuir model. Release kinetics of the adsorbed drug were also evaluated by in vitro dissolution tests. Results showed that domperidone can be uniformly dispersed into the aerogel and that the release rate of domperidone from the composite, constituted by drug and silica aerogel, is much faster than that…

Solubility of some pesticides in supercritical CO2

1988

The solubility limits of some pesticides (Linuron, Methoxychlor, Diclofopmethyl, Diclofop and 2,4-D) and of 3,4-dichloroaniline have been determined in supercritical CO2 at 200 bar and 40° C, using the Milton Roy sample preparation accessory SPATM. Depending on the polarity and vapour pressure of the investigated compounds, the solubility was found to be between 0.3 and 12 gl−1.

Supercritical Fluid Extraction and Supercritical Fluid Chromatography of Vitamin E in Pharmaceutical Preparations

1999

Traditional and new analytical methodology

2010

International audience

Antihypertensive effect of a bovine lactoferrin pepsin hydrolysate: Identification of novel active peptides

2012

et al.

The use of direct determination of chromium in human urine by electrothermal atomic absorption spectrometry in diabetic patients.

1991

EDTA excess Zn(II) back-titration in the presence of 4-(2-pyridylazo)-resorcinol indicator and naphthol green beta as inert dye for determining Cr(II…

2006

The colour changes of 4-(2-pyridylazo)-resorcinol and naphthol green beta as new screening metallochromic indicator in back-titration of EDTA excess with Zn(II) to determine Cr(III)/EDTA complex was investigated with the help of tristimulus colorimetry. Specific colour discrimination (SCD) and L*, a*, b* 1976 parameters were successfully applied to evaluate the quality of colour transition at the end-point in non-alkaline media and in the presence of Zn(II) and Ca(II) which resulted in non-interfering species at 1x10(-3) M and 2x10(-3) M, respectively. The above concentrations are comparable with those used for Cr(III). Validation of the fast and accurate reported method was performed by at…