Search results for "formation."

Rho GTPases are over-expressed in human tumors.

1999

Small GTPases of the Rho family are involved in the regulation of a variety of cellular processes, such as the organization of the microfilamental network, cell-cell contact and malignant transformation. To address the question of whether Rho proteins are involved in carcinogenesis in man, we compared their expression in tumors from colon, breast and lung with that of the corresponding normal tissue originating from the same patient. As shown by Rho-specific 32P-ADP-ribosylation, as well as Western-blot analysis, the amount of RhoA protein was largely increased in all 3 types of tumors tested. The most dramatic differences in the expression of Rho GTPases were observed in breast tissue. All…

Rho GTPases: Promising Cellular Targets for Novel Anticancer Drugs

2006

Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. Rho GTPases are localized at membranes and become activated upon stimulation of cell surface receptors. In their GTP-bound (=active) state, Rho proteins bind to effector proteins, thereby triggering specific cellular responses. Members of the Rho family of small GTPases are key regulators of actin reorganization, cell motility, cell-cell and cell-extracellular matrix (ECM) adhesion as well as of cell cycle progression, gene expression and apoptosis. Each of these functions is of importance for the development and progression of cancer. Fu…

The Effect of Mechanocatalytic Pretreatment on the Structure and Depolymerization of Willow

2020

In this study, the effect of a mechanocatalytic pretreatment on the structure of willow and sugar release from pretreated willow was explored. In the mechanocatalytic approach, the pretreatment consists of solvent-free impregnation with sulfuric acid and a mechanical treatment with ball milling. Willow sawdust and pretreated samples were analyzed with field emission scanning electron microscope and X-ray diffraction. The products in the sugar solution were determined as the total reducing sugars with the 3,5-dinitrosalicylic acid method and monosaccharides with capillary electrophoresis. According to the results, milling increased the sugar production, depending on the sulfuric acid load. T…

Strategic Cyber Environment Management with Zero Trust and Cyber Counterintelligence

2022

Organisations need to improve their information security practices, given the volume of successful cyberattacks and crimes. To enhance security in an organisation, information security must be considered a business issue, instead of a technical problem. Hence, organisations must change the security protocol from reactive action to proactive operation; must develop information security strategies that support the business; should implement better controls, systems, and services; and must create a process to proactively gather information about the possible threats and adversaries. This study proposes a novel method for combining a zero-trust strategy with cyber counterintelligence to gain th…

Visuaalinen haku MacIntosh-käyttöliittymässä

1998

GRANULAR-INFORMATION-BASED RISK ANALYSIS IN UNCERTAIN SITUATIONS

2006

In the real life almost all of the decisions that we have to make incorporate uncertainty about the future events. Assessment of the uncertainty and, thus, the risk that is inherent in these decisions models can be critical. It is even truer if we are talking about the possibility of negative impact on the environment. It is very important to assess all the environmental risks in a project if there is any hazard to the environment. In this paper the possibility of using granular information is considered. The main advantage of the granular information is that it can be used to assess risks in situations when information about future events is incomplete and imprecise. Moreover, we can use n…

Are Brands Postmodern Relics? Taking a Closer Look at New Sacred Objects

2011

Summary : Ever since the Church lost its monopoly on the sacred, no longer able to solely determine its form or contents, the social sphere has gradually taken over this value, applying it to new human and social objects. As a result, the modes of expression of the sacred have multiplied, along with the subjective and intimate experiences of modern individualism. Among the vast number of potential manifestations of this value, to which almost everything now seems to aspire, this paper will concentrate on commercial brands as vectors of meaning, with the hypothesis that some of them seek to position themselves, in postmodern society, as new figures of the sacred. This area of study is close …

Regard anthropologique sur les cultures de la table

2006

Chirurgische Ausbildung im digitalen Zeitalter – Virtual Reality, Augmented Reality und Robotik im Medizinstudium

2021

The digital transformation of healthcare is changing the medical profession. Augmented/Virtual Reality (AR/VR) and robotics are being increasingly used in different clinical contexts and require supporting education and training, which must begin within the medical school. There is currently a large discrepancy between the high demand and the number of scientifically proven concepts. The aim of this thesis was the conceptual design and structured evaluation of a newly developed learning/teaching concept for the digital transformation of medicine, with a special focus on the influence of surgical teaching.Thirty-five students participated in three courses of the blended learning curriculum "…

Modeling ontologies for robotic environments

2002

On the basis of a multiple abstraction levels specification process, we developed a representational model for environmental robotic knowledge through the definition of a set of ontologies using a multi perspective approach. A general ontological model for typical indoor environments has been first developed, followed by its specialization using an implementation perspective. Actual software implementation of the ontology has been obtained via a XML-based markup language, used to build a repository for robotic environmental knowledge. Copyright 2002 ACM.