Search results for "interactions."
showing 10 items of 1865 documents
Le menu au restaurant : construction pragmatique de l’expérience gastronomique et enjeux identitaires
2014
International audience; Ce travail de recherche, ancré dans le champ de l’analyse conversationnelle (Sacks, 1992), est basé sur un corpus d’enregistrements vidéo réalisé en contexte naturel de production dans plusieurs restaurants de type gastronomique en France. Les données collectées sont transcrites finement afin de rendre compte des ressources linguistiques et multimodales (Mondada, 2008) mobilisées par les participants à l’interaction.Dans notre corpus, nous avons constaté que le menu est un objet important dans l’organisation du service au restaurant et qu’il est utilisé à différentes fins pratiques selon les séquences d’activités et selon les participants qui l’utilisent (personnels …
Le menu au restaurant : textualité, oralité et usages en interaction.
2012
International audience; Ce travail de recherche, ancré dans le champ de l’analyse conversationnelle (Sacks, 1992), est basé sur un corpus d’enregistrements vidéo réalisé en contexte naturel de production dans plusieurs restaurants de type gastronomique en France. Les données collectées sont transcrites finement afin de rendre compte des ressources linguistiques et multimodales (Mondada, 2008) mobilisées par les participants à l’interaction.Dans notre corpus, nous avons constaté que le menu est un objet important dans l’organisation du service au restaurant et qu’il est utilisé à différentes fins pratiques selon les séquences d’activités et selon les participants qui l’utilisent (personnels …
Inhibition of small G proteins of the Rho family by statins orClostridium difficiletoxin B enhances cytokine-mediated induction of NO synthase II
2000
In order to investigate the involvement of Ras and/or Rho proteins in the induction of the inducible isoform of nitric oxide synthase (NOS II) we used HMG-CoA reductase inhibitors (statins) and Clostridium difficile toxin B (TcdB) as pharmacological tools. Statins indirectly inhibit small G proteins by preventing their essential farnesylation (Ras) and/or geranylgeranylation (Rho). In contrast, TcdB is a glucosyltransferase and inactivates Rho-proteins directly. Human A549/8- and DLD-1 cells as well as murine 3T3 fibroblasts were preincubated for 18 h with statins (1–100 μM) or TcdB (0.01–10 ng ml−1). Then NOS II expression was induced by cytokines. NOS II mRNA was measured after 4–8 h by R…
The Influence of Nanoparticle Shape on Protein Corona Formation
2020
Nanoparticles have become an important utility in many areas of medical treatment such as targeted drug and treatment delivery as well as imaging and diagnostics. These advances require a complete understanding of nanoparticles' fate once placed in the body. Upon exposure to blood, proteins adsorb onto the nanoparticles surface and form a protein corona, which determines the particles' biological fate. This study reports on the protein corona formation from blood serum and plasma on spherical and rod‐shaped nanoparticles. These two types of mesoporous silica nanoparticles have identical chemistry, porosity, surface potential, and size in the y ‐dimension, one being a sphere and the other a …
Olfactory cues and the value of information : Voles interpret cues differently based on recent predator encounters
2018
Prey strategically respond to the risk of predation by varying their behavior while balancing the tradeoffs of food and safety. We present here an experiment that tests the way the same indirect cues of predation risk are interpreted by bank voles, Myodes glareolus, as the game changes through exposure to a caged weasel. Using optimal patch use, we asked wild-caught voles to rank the risk they perceived. We measured their response to olfactory cues in the form of weasel bedding, a sham control in the form of rabbit bedding, and an odor-free control. We repeated the interviews in a chronological order to test the change in response, i.e., the changes in the value of the information. We found…
Safety and potential interaction of immunosuppressive drugs for the treatment of inflammatory bowel disease in elderly patients
2021
Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, are chronic diseases associated with increased morbidity and reduced quality of life. Age may represent a risk factor for adverse events, due to the multimorbidity and polypharmacy, common in elderly patients. Elderly are often not included in clinical trials evaluating efficacy and safety of study drugs for the treatment of inflammatory bowel diseases. Several drugs, such as aminosalicylates, systemic corticosteroids, immunosuppressant drugs, biological drugs and Janus Kinase inhibitors, are available for the management of inflammatory bowel diseases. With the increasing spectrum of therapeutic options, it is th…
Tenapanor for the treatment of irritable bowel syndrome with constipation.
2020
Introduction: Irritable bowel syndrome with constipation is associated with higher rates of functional impairment, as compared to other subtypes of the syndrome. Conventional laxative-based pharmacologic therapy of IBS-C, which is mostly symptom-based, is often unsatisfactory. Tenapanor represents a first-in-class orally available inhibitor of NHE3, which is minimally absorbed in the GI tract, what constitutes a significant therapeutic benefit, as it may act on the drug target. Areas covered: Aim of this article is to sum up the evidences about pharmacodynamics and pharmacokinetics of tenapanor, focusing on animal models and in vitro studies, but also discuss clinical trials on tenapanor's …
Dual action of phosphonate herbicides in plants affected by herbivore—Model study on black bean aphid Aphis fabae rearing on broad bean Vicia faba pl…
2008
Abstract The interactions between plants, herbicides and herbivore insects were studied as an aspect of possible side effect of the using of phosphonate herbicides. The experimental system was composed of phosphonate herbicides, broad bean Vicia faba (L.) plants and black bean aphid Aphis fabae (Scopoli). Two means of herbicide application, namely standard spraying and direct introduction of the herbicide into stem via glass capillary, were examined. The results obtained for N-2-piridylaminomethylene bisphosphonic acid and its derivatives show 10 times higher inhibition of the plant growth if glass capillary mode was used. When plants were infested by aphids 24 h after the use of herbicide,…
Research data supporting "Social learning within and across predator species reduces attacks on novel aposematic prey"
2019
This data is from the experiment that investigated how wild-caught blue tits and great tits use conspecific and heterospecific information about unpalatable prey, published at the Journal of Animal Ecology (2020). The experiment was conducted at the Konnevesi Research Station from October to December 2017. Sheet 1 (“Main experiment”) contains data from the main avoidance learning experiment. Sheets 2 (“Symbol preference blue tits”) and 3 ("Symbol visibility blue tits") contain data of blue tits' symbol choices in initial preference and visibility tests.
Shell-model computed cross sections for charged-current scattering of astrophysical neutrinos off 40Ar
2018
Charged-current (anti)neutrino-$^{40}\mathrm{Ar}$ cross sections for astrophysical neutrinos have been calculated. The initial and final nuclear states were calculated using the nuclear shell model. The folded solar-neutrino scattering cross section was found to be $1.78(23)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}42}\phantom{\rule{4pt}{0ex}}{\mathrm{cm}}^{2}$, which is higher than what the previous papers have reported. The contributions from the ${1}^{\ensuremath{-}}$ and ${2}^{\ensuremath{-}}$ multipoles were found to be significant at supernova-neutrino energies, confirming the random-phase approximation (RPA) result of a previous study. The effects of neutrino flavor conve…