Search results for "lp(a)"
showing 10 items of 657 documents
Kilpailua vai yhteistyötä? Ristiriidat hiertävät tutkijan työtä
2012
Tieteen edistys vaatii tiedon peittelemätöntä jakamista, mutta kiristynyt kilpailu saa monet tutkijat miettimään avoimuutensa rajoja. nonPeerReviewed
The Effect of Using Noise Cancellation Earplugs in Open-plan Offices of the Work Well-being and Work Performance of Software Professionals
2017
The popularity of open-plan offices has been on the rise recently and expanded to all sectors of working life. While moving to open-plan offices brings savings to companies, open-plan offices have been connected with various different negative consequences, such as noise. Noise has been found to be a central cause of dissatisfaction towards working in an open-plan office and lead to subsequent negative outcomes, such as decreased self-perceived health and weakened cognitive performance. Therefore, it is important to study the ways and technologies that could possibly mitigate the negative effects of noise on work well-being and work performance. This explorative study investigates both the …
Subcellular distribution of calpain-1 and calpain-2 as a key event for calpain-mediated functions in physiological and neoplastic mammary models
2019
Calpains are a family of calcium-dependent proteases, which modulate their substrates rather than degrade them in such a way that modifies them. Calpains deregulations have been determined as an aggravating factor of different diseases, including cancer. Nevertheless, there are no clear records about the particular contribution of each calpain isoform in physiological processes and how these isoforms are deregulated in pathological conditions. In vivo, each calpain isoform recognizes specific proteins as substrates, and it has been suggested that calpains subcellular localization might determine their substrate recognition, and consequently their functions. In the present study we have expl…
La calpaína-2 en el núcleo de células de cáncer de mama: De la identificación de dianas nucleares a la función
2022
La calpaína-2 (CAPN2) es una cisteín-proteasa dependiente de Ca2+ de distribución ubicua en mamíferos. Proteoliza de forma limitada sus sustratos, modificando su función, distribución, interacción con otras proteínas o regulación. Se ha postulado que la gran variedad de funciones de la CAPN2 depende de su distribución subcelular y de su acceso a sustratos específicos. El papel de la CAPN2 en la membrana celular o en el citosol se ha estudiado en diferentes tipos celulares para explicar funciones como la migración, adhesión o muerte celular. Sin embargo, las funciones de la CAPN2 nuclear no se han estudiado en profundidad. Identificar los componentes dependientes de la CAPN2 en el núcleo, ay…
nota in tema di responsabilità medica
2016
Causalità e colpa nell'esposizione dei lavoratori alle polveri di amianto fra "caos" e "logos"
2009
L’esperienza giurisprudenziale in materia di esposizione dei lavoratori alle polveri di amianto costituisce un banco di prova particolarmente utile per una rigorosa verifica delle elaborazioni teoriche concernenti la causalità e la colpa. Sul versante della causalità, al progressivo abbandono di posizioni incentrate sull’eccessiva enfatizzazione del quantum di probabilità statistica ha fatto seguito la graduale ammissione del criterio della credibilità razionale. Tale importante mutamento di approccio non è stato tuttavia sufficiente a eliminare in modo radicale la tendenza della giurisprudenza a confondere il profilo della spiegazione causale/naturalistica con il profilo dell’imputazione n…
Type V collagen-induced upregulation of capn2 (large subunit of m-calpain) gene expression and DNA fragmentation in 8701-BC breast cancer cells
2011
Abstract Type V collagen is known to be over-deposited in the stroma of ductal infiltrating carcinomas of the breast. When used as a substrate, type V collagen restrains growth and invasion, and affects gene expression of 8701-BC ductal infiltrating carcinomas cells. Here we supplement existing data by demonstrating type V collagen dependent upregulation of capn2 gene expression in 8701-BC cells through differential display-PCR and Western blot assays. Furthermore, we suggest that our data obtained by centrifugal sedimentation and electrophoresis strongly suggest a correlation between calpain overproduction and DNA fragmentation, since the incubation with calpain inhibitor partly reverts th…
Ecological and evolutionary consequences of selective interspecific information use
2023
Recent work has shown that animals frequently use social information from individuals of their own species as well as from other species; however, the ecological and evolutionary consequences of this social information use remain poorly understood. Additionally, information users may be selective in their social information use, deciding from whom and how to use information, but this has been overlooked in an interspecific context. In particular, the intentional decision to reject a behaviour observed via social information has received less attention, although recent work has indicated its presence in various taxa. Based on existing literature, we explore in which circumstances selective i…
Coach-athlete perceived congruence between actual and desired emotions in karate competition and training
2018
Coaches can help athletes regulate emotions but would benefit from tools that help them accurately perceive athletes' emotions. In the present study, we investigated the use of video-recorded performances to compare 3 martial artists' ratings of desired and actual emotions with their coach's ratings. Results show how desired emotions progressively fluctuated throughout competition. Furthermore, desired and actual emotions differed between training and performance contexts. Finally, we report correlations between performance and perceived congruence in desired and actual emotions. Cumulatively, results offer support for the video-assisted recall of emotions as an intervention tool in develop…
Responsabilità dello spacciatore per la morte del tossicodipendente: le Sezioni Unite optano per la colpa in concreto
2009
Il lavoro sottopone ad analisi critica il ricorso al criterio dell'agente ragionevole proposto dalle sezioni unite della cassazione per diagnosticare la presenza della colpa in concreto nelle attività illecite