Search results for "marker"
showing 10 items of 3799 documents
Proteomic discovery of new differentiation markers in the U937 cell line
2009
MILLSTONES COASTAL QUARRIES AS INDICATOR OF RELATIVE SEA LEVEL CHANGES
2012
The Italian coasts shows numerous archaeological remains which reveals the activities that were carried out along the coast for thousands of years of history. In order to use archaeological structures for coastal studies, an accurate estimate of their relationship to the sea level at the time of construction is required (Lambeck et al 2004, Antonioli et al 2007, Auriemma & Solinas 2009). Millstone coastal quarries are only documented in southern Italy; they are carved on beachrock, calcarenites and other sedimentary rock easy to be exploited. Few archaeological information have been published about quarries for millstones extraction; they are documented since around 2500 yr BP (Amouretti, 1…
Conditional connection explored: the case of Sicilian cusà
2022
Abstract Stemming from a wh-question, the Sicilian marker cusà (cu sa ‘who knows’) expresses several epistemic meanings, which can also reach the realm of conditionality. The paper explores the discourse profile of cusà as it emerges from the analysis of diachronic data (from the eighteenth and nineteenth centuries) and present-day informal Sicilian, namely spoken Sicilian and present-day informal Sicilian as written by speakers on the web. These data suggest a possible path of development leading from the wh-question to new functions. We propose that the origin of this development can be explained in the light of the strategy of the “impossible question”, while the diverse functions of cus…
Robotics Construction Kits: From “Objects to Think with” to “Objects to Think and to Emote with”
2018
This paper discusses new ideas about the use of educational robotics in social-emotional learning. In particular, educational robotics could be a tool intended to allow children to acquire some of the basic aspects of human emotions and emotional functioning, and to understand how these relate to the mind and body. More specifically, by using robots such as the LEGO Mindstorm construction kits—which allow users to both construct the body of the robot and to provide it with a behavioural repertory—children have the opportunity to visualize (and manipulate) the relationship between the robot’s body and mind. This allows them to simulate “embodied emotional minds” and to reflect on new neurosc…
Genetic risk factors and candidate biomarkers for Alzheimer s disease
2009
Alzheimer's disease is a multifactorial and progressive neurodegenerative disease, extremely diffused and with an increasing prevalence worldwide. There is an urgent need for biomarkers to diagnose AD early in its course. Furthermore, accurate biomarkers would be able to determine the clinical efficacy of novel neuroprotective strategies. Although the heritability of late-onset AD is high, our knowledge of the underlying putative susceptibility genes remains incomplete and the only unequivocally established late-onset AD gene is APOE. Nevertheless a number of susceptibility loci seems to influence the pathogenesis of AD, and variations in numerous genes have been considered to be important …
Prognostic value of IL-6 and IL-10 serum levels and immunonutritional assessment in determining postoperative complications after geriatric surgery
2009
The onset of postoperative septic complications has recently been associated to serum levels of interleukin (IL) IL-6 and IL-10. Patients with complications have higher serum levels than patients without complication after surgery. IL-6 has been recognized as early marker of postoperative septic events. Furthermore IL-6 increases with age, expecially if there are associated diseases. It is a sign of functional deterioration of different organs. The disregulation in interleukin production, anesthetic drugs, hemorrhage and transfusions may lead to the onset of postoperative complications. The latter are more frequent in oncologic patients. The aim of our study is to evaluate pre- and postoper…
Biomarkers of aging
2010
Aging is a complex process that negatively impacts the development of the different systems and its ability to function. Moreover, the Aging rate in humans is not the same, principally due to genetic heterogeneity and environmental factors. The aging rate is measured as the decline of functional capacity and stress resistance. Therefore, several attempts have been made to analyse the individual age, ( so-called biological age) compared to chronological age. The biomarkers of aging are age-related body function or composition, these markers aim to assess the biological age and predict the onset of age-related diseases and/or residual lifetime. Such biomarkers should help in one hand to chara…
Endothelial Progenitor Cells A New Real Hope?
2017
Chronic inflammatory diseases, such as cardiovascular diseases (CVDs), diabetes, Alzheimer’s disease (AD) and cancer, have a disproportionate prevalence with advancing age owing to the continuous growth in the aging population. This condition determines several medical, economic and social problems due to the dramatic increase in the number of affected individuals, who are not autonomous. Thus, research efforts are centred around reducing and/or delaying the onset and progression of these diseases by researching new strategies for early prevention and diagnosis. In this context, understanding the mechanisms involved in the tissue, organ protection and repair are imperative for the developme…