Search results for "myocardial infarction."

showing 10 items of 1011 documents

Plaque and blood vulnerability in ST segment elevation myocardial infarction patients: association between lesion morphology using intravascular ultr…

2013

AIM The purpose of the study was to evaluate associations between iMap intravascular ultrasound tissue characterization of culprit and nonculprit lesions in infarct-related artery and plasma biomarkers during ST segment elevation myocardial infarction (STEMI) and at 10-month follow-up. METHODS AND RESULTS Sixty-three STEMI patients at the time of index hospitalization and 10-month follow-up underwent coronary angiography and intravascular ultrasound with iMap tissue characterization of the culprit artery. Proximal and culprit segments were analyzed. A higher percentage of necrotic tissue in the nonculprit segment was found in patients in the top soluble intercellular adhesion molecule 1 (sI…

MaleAcute coronary syndromemedicine.medical_specialtyTime FactorsMyocardial InfarctionCoronary AngiographyCulpritLesionchemistry.chemical_compoundNecrosisPercutaneous Coronary InterventionPredictive Value of TestsInternal medicineIntravascular ultrasoundPlasminogen Activator Inhibitor 1medicineST segmentHumansMyocardial infarctionProspective StudiesUltrasonography InterventionalAgedmedicine.diagnostic_testbusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseIntercellular Adhesion Molecule-1Coronary VesselsFibrosisPlaque Atheroscleroticmedicine.anatomical_structureTreatment OutcomechemistryPlasminogen activator inhibitor-1CardiologyFemalemedicine.symptomCardiology and Cardiovascular MedicinebusinessBiomarkersArteryCoronary artery disease
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Non-vitamin K antagonist oral anticoagulants in the treatment of coronary and peripheral atherosclerosis

2019

Oral anticoagulants (OACs) are widely used for prevention of systemic thromboembolism, including the reduction of the risk of stroke in patients with atrial fibrillation (AF) and prosthetic heart valves. There is also an increasing population of patients who require not only OACs, but also double antiplatelet therapy (DAPT). A typical example is a patient with AF and stable coronary artery disease or acute coronary syndrome (ACS), treated by percutaneous coronary intervention. In recent years, with the introduction of NOACs, triple or dual therapy has become safer. Regardless of these indications for the use of NOACs, rivaroxaban at a reduced dose has proved to efficiently reduce the risk o…

MaleAcute coronary syndromemedicine.medical_specialtymedicine.drug_classmedicine.medical_treatmentCardiologyAdministration OralCoronary Artery Disease030204 cardiovascular system & hematologyCoronary artery disease03 medical and health sciences0302 clinical medicineRivaroxabanThromboembolismInternal medicinemedicineHumansMyocardial infarctionStrokeSocieties MedicalRivaroxabanAspirinAspirinbusiness.industryAnticoagulantsPercutaneous coronary interventionVitamin K antagonistAtherosclerosismedicine.diseaseCardiologyDrug Therapy CombinationFemalePolandCardiology and Cardiovascular Medicinebusinessmedicine.drugKardiologia Polska
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Contemporary differences between men and women with acute coronary syndromes: CIAM multicenter registry.

2019

AIM Differences exist in the diagnosis and treatment of acute coronary syndrome (ACS) between men and women. However, recent advancements in the management of ACSs might have attenuated this sex gap. We evaluated the status of ACS management in a multicenter registry in 10 tertiary Spanish hospitals. METHODS We enrolled 1056 patients in our study, including only those with type 1 myocardial infarctions or unstable angina presumably not related to a secondary cause in an 'all-comers' design. RESULTS The women enrolled (29%) were older than men (71.0 ± 12.8 vs. 64.0 ± 12.3, P = 0.001), with a higher prevalence of hypertension (71.0 vs. 56.5%, P < 0.001), insulin-treated diabetes (13.7 vs. 7.9…

MaleAcute coronary syndromemedicine.medical_specialtymedicine.medical_treatmentMyocardial Infarction030204 cardiovascular system & hematologyRevascularizationRisk AssessmentAngina03 medical and health sciences0302 clinical medicineSex FactorsRisk FactorsInternal medicinePalpitationsPrevalenceMedicineHumans030212 general & internal medicineAngina UnstableProspective StudiesRegistriesAcute Coronary SyndromeHealthcare DisparitiesProspective cohort studyAgedAged 80 and overbusiness.industryUnstable anginaAge FactorsGeneral MedicineHealth Status DisparitiesMiddle Agedmedicine.diseaseTreatment OutcomeSpainFemalemedicine.symptomCardiology and Cardiovascular MedicinebusinessDyslipidemiaKidney diseaseJournal of cardiovascular medicine (Hagerstown, Md.)
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Invasive Strategy in Patients With Advanced Diabetes and Non-ST-Segment Elevation Acute Coronary Syndrome. Angiographic Findings and Clinical Follow-…

2006

Introduction and objectives Advanced diabetes can be associated with diffuse coronary artery disease that is difficult to treat by revascularization. We studied angiographic findings and disease progression in patients with advanced diabetes (either insulin-dependent or taking antidiabetic drugs for >5 years) and non-ST-elevation acute coronary syndrome who were being treated using an invasive strategy. Methods The study included 141 patients. The extent of the coronary artery disease was quantified using a score derived from a 29-segment coronary angiogram. The composite endpoint was death, myocardial infarction, or readmission for unstable angina within one year of follow-up. Results The …

MaleAcute coronary syndromemedicine.medical_specialtymedicine.medical_treatmentMyocardial InfarctionCoronary AngiographyRevascularizationDiabetes ComplicationsCoronary artery diseaseElectrocardiographyInternal medicineDiabetes mellitusMyocardial RevascularizationmedicineHumansAngina UnstableProspective StudiesMyocardial infarctionAgedKillip classEjection fractionUnstable anginabusiness.industrySyndromeGeneral Medicinemedicine.diseaseAcute DiseaseDisease ProgressionCardiologyFemalebusinessFollow-Up StudiesRevista Española de Cardiología (English Edition)
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Prevalence and prognostic impact of nonischemic late gadolinium enhancement in stress cardiac magnetic resonance

2020

Aim To assess the prevalence and prognostic significance of NI-LGE in patients undergoing stress-CMR. Methods Stress-CMR with either dipyridamole or adenosine was performed in 283 patients (228 men, 81%) including perfusion imaging, wall motion evaluation and LGE. Follow-up was completed in all enrolled patients (median time: 1850 days; interquartile range: 1225-2705 days). Composite endpoint included cardiac death, ventricular tachycardia, myocardial infarction, stroke, hospitalization for cardiac cause and coronary revascularization performed beyond 90 days from stress-CMR scans. Results One hundred and twelve patients (40%) had negative LGE (no-LGE), 140 patients (49%) I-LGE and 31 patie…

MaleAdenosineTime FactorsVasodilator AgentsContrast MediaPerfusion scanning030204 cardiovascular system & hematologyVentricular tachycardia0302 clinical medicineRisk FactorsInterquartile rangePrevalence030212 general & internal medicineMyocardial infarctionStrokenonischemic fibrosislate gadolinium enhancement; nonischemic cardiac findings; nonischemic fibrosis; prognosis; stress perfusion cardiac magnetic resonanceDipyridamoleGeneral MedicineMiddle AgedMagnetic Resonance ImagingDipyridamolelate gadolinium enhancementstress perfusion cardiac magnetic resonanceembryonic structurescardiovascular systemCardiologyFemaleCardiology and Cardiovascular MedicinePerfusionmedicine.drugnonischemic cardiac findingsmedicine.medical_specialtyHeart DiseasesPerfusion ImagingRisk Assessment03 medical and health sciencesPredictive Value of TestsInternal medicinemedicineHumanscardiovascular diseasesSurvival analysisAgedRetrospective Studiesbusiness.industryMyocardiummedicine.diseaseFibrosisLate gadolinium enhancement Nonischemic cardiac findings Nonischemic fibrosis Prognosis Stress perfusion cardiac magnetic resonanceprognosisbusinessJournal of Cardiovascular Medicine
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The assessment of scales of frailty and physical performance improves prediction of major adverse cardiac events in older adults with acute coronary …

2019

Abstract Background The number of older adults admitted to hospital for acute coronary syndrome (ACS) has increased worldwide. The aim of this study was to determine which scale of frailty or physical performance provides incremental improvements in risk stratification of older adults after ACS. Methods A prospective cohort of 402 older (≥70 years) ACS patients were enrolled. Data about baseline characteristics, Global Registry of Acute Coronary Events (GRACE), and Thrombolysis in Myocardial Infarction (TIMI) risk scores were collected. Before hospital discharge, seven scales of frailty and physical performance were measured. The 1-year occurrence of adverse events (cardiac death, reinfarct…

MaleAgingAcute coronary syndromemedicine.medical_specialtymedicine.medical_treatmentAcute coronary syndrome; ST-segment elevation myocardial infarction; frailty; short physical performance batteryshort physical performance batteryfrailty030204 cardiovascular system & hematologyRisk AssessmentStatistics NonparametricNO03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicinemedicineHumansProspective Studies030212 general & internal medicineMyocardial infarctionAdverse effectProspective cohort studyGeriatric AssessmentAgedbusiness.industryConfoundingThrombolysismedicine.diseaseClinical trialST-segment elevation myocardial infarctionPhysical FitnessExercise TestCardiologyFemaleAcute coronary syndromeGeriatrics and GerontologybusinessTIMI
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Longitudinal association of handgrip strength with all-cause and cardiovascular mortality in older adults using a causal framework.

2022

To date, there is no study addressing the time-varying confounding bias in the association of handgrip strength (HGS) with all-cause or cardiovascular mortality. Therefore, we conducted marginal structural models (MSM) to provide causal estimations on the associations of HGS with all-cause and cardiovascular mortality in a representative sample of adults aged 50 years or older. Data from 29 countries including 121,116 participants (276,994 observations; mean age 63.7 years; 56.3 % women) free from prior heart attack or stroke were retrieved from consecutive waves of the Survey of Health, Ageing and Retirement in Europe (SHARE). During a median of 7.7 years follow-up (interquartile range 3.8…

MaleAgingHand StrengthMyocardial InfarctionExerciciCell BiologyBiochemistryStrokeEndocrinologyEducació física per a persones gransGeneticsHumansFemaleMuscle StrengthMolecular BiologyAgedExperimental gerontology
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Analysis of polymorphisms Leiden Factor V G1691A and prothrombin G20210A as risk factors for acute myocardial infarction.

2011

Thrombotic risk increases in elderly, therefore, the understanding of the genetic predisposition of hypercoagulability could make the difference in the prevention of venous and/or arterial thrombotic events. Laboratory evaluation of hyperfibrinogenemia, increased Factor VII levels, antiphospholipid antibodies presence and hyperhomocysteinemia are considered to have a consistent high predictivity for arterial thrombophilic diseases. Anyway, a large debate exists on the validity of testing Leiden Factor V (FV) G1691A and/or prothrombin (FII) G20210A polymorphisms in patients affected by arterial thrombotic diseases, despite of the several observations described. Here we report data strongly s…

MaleAgingmedicine.medical_specialtyHyperhomocysteinemiaLeiden Factor V; Prothrombin; Stroke; Guidelines; Arterial thrombosis.Myocardial InfarctionHyperfibrinogenemiaGuidelineGUIDELINESGastroenterologyCohort Studieschemistry.chemical_compoundInternal medicineArterial DisorderGenotypeGenetic predispositionmedicineHumansGenetic Predisposition to DiseaseMyocardial infarctionAgedAged 80 and overPolymorphism GeneticFactor VIIbusiness.industryFactor VMiddle Agedmedicine.diseaseSurgeryStrokeTHROMBOSISchemistryArterial thrombosis.Prothrombin G20210AFemaleProthrombinGeriatrics and GerontologybusinessGerontologyLeiden Factor V
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SARS CoV2 infection _The longevity study perspectives

2021

Graphical abstract

MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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High N-Terminal Pro-B-Type Natriuretic Peptide Levels Are Associated with Reduced Heart Rate Variability in Acute Myocardial Infarction

2012

AIM: We investigated the relationships between the autonomic nervous system, as assessed by heart rate variability (HRV) and levels of N-terminal Pro-B-type Natriuretic Peptide (Nt-proBNP) in patients with acute myocardial infarction (MI). METHODS AND RESULTS: The mean of standard deviation of RR intervals (SDNN), the percentage of RR intervals with >50 ms variation (pNN50), square root of mean squared differences of successive RR intervals (rMSSD), and frequency domain parameters (total power (TP), high frequency and low frequency power ratio (LF/HF)) were assessed by 24 h Holter ECG monitoring. 1018 consecutive patients admitted <24 h for an acute MI were included. Plasma Nt-proBNP (Elecs…

MaleAnatomy and PhysiologyEpidemiologyMyocardial Infarctionlcsh:MedicineArrhythmiasCardiovascularCardiovascular SystemHeart RateNatriuretic Peptide BrainPathologyNatriuretic peptideHeart rate variabilityMyocardial infarctionlcsh:Scienceeducation.field_of_studyMultidisciplinaryEjection fractionMiddle AgedQuartileCardiologyMedicineFemaleResearch Articlemedicine.medical_specialtymedicine.drug_classPopulationAutonomic Nervous SystemDiagnostic MedicineInternal medicineHeart ratemedicineHumanscardiovascular diseasesProtein PrecursorseducationBiologyAgedHeart Failurebusiness.industryAcute Cardiovascular Problemslcsh:Rmedicine.diseasePeptide FragmentsBiomarker EpidemiologyAutonomic nervous systemEndocrinologyElectrocardiography Ambulatorylcsh:QbusinessBiomarkersGeneral PathologyPLoS ONE
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