Search results for "pair"

Oxidative Stress and DNA Damage in Human Gastric Carcinoma: 8-Oxo-7'8-dihydro-2'-deoxyguanosine (8-oxo-dG) as a Possible Tumor Marker

2013

We characterized the oxidative stress (OS) status by the levels of reduced/oxidized glutathione (GSH/GSSG), malondialdehyde (MDA) and the mutagenic base 8-oxo-7'8-dihydro-2'-deoxyguanosine (8-oxo-dG) in human gastric carcinoma (HGC) samples and compared the results with normal tissue from the same patients. We also analyzed 8-oxo-dG in peripheral mononuclear cells (PMNC) and urine from healthy control subjects and in affected patients in the basal state and one, three, six, nine and twelve months after tumor resection. The levels of DNA repair enzyme mRNA expression (hOGG1, RAD51, MUYTH and MTH1) were determined in tumor specimens and compared with normal mucosa. Tumor specimens e…

Formulation of Different Chitosan Hydrogels for Cartilage Tissue Repair

2014

Different formulations of Chitosan/sulphate and Chitosan/PEGDE were produced by physical and chemical reticulation to obtain hydrogels with better physiochemical properties. The hydrogels were analyzed – in terms of their non-toxicity, proliferative, differentiative, inflammatory and immunology responses. Commercial grade Chitosan (Sigma) was solubilized and purified by progressive filtrations. Then, the polymer was freeze-dried in a water soluble cationic form. A physical hydrogel was prepared by mixing a 3 % w/w water solution of the a.m. polymer with different stoichiometric ratios of (SO4=) 1/0.5;1/0.75;1/1 respectively. The hydrogels were cross-linked in multiwells. The chemical hydrog…

Advancing stem cells: New therapeutic strategies for treating central nervous system disorders

2018

In this special issue, we explore new methods and knowledge to improve stem cell transplantation in diseases and conditions such as stroke, PD, and depression. Advancing the conventional idea regarding cell replacement in stem cell therapy, stem cells may also transfer healthy mitochondria to diseased ischemic neurons in stroke and improve the therapeutic time window of tissue plasminogen activator (tPA) in a conjunctive therapy for stroke, and human Wharton’s Jelly-derived mesenchymal stromal cells (hWJ-MSCs) may rely mainly on trophic factor secretion to induce neuroprotective effects. In addition, trophic factors such as neurotrophin-4/5 (NT-4/5) and glial cell line-derived neurotrophic …

Pathophysiology of vascular dementia.

2009

The concept of Vascular Dementia (VaD) has been recognized for over a century, but its definition and diagnostic criteria remain unclear.Conventional definitions identify the patients too late, miss subjects with cognitive impairment short of dementia, and emphasize consequences rather than causes, the true bases for treatment and prevention. We should throw out current diagnostic categories and describe cognitive impairment clinically and according to commonly agreed instruments that document the demographic data in a standardized manner and undertake a systematic effort to identify the underlying aetiology in each case.Increased effort should be targeted towards the concept of and criteri…

Evaluating Safety Systems for Machine Tools with Computer Numerical Control using Analytic Hierarchy Process

2019

Computer numerical control (CNC) machine tools are complex production systems with fully automatic machine parts. Nowadays, high feed rates and machining speeds are used during the machining process. Human operators are still needed to set-up the machine, load/unload workpieces and parts, load the machining code, and supervise the machining process. The operators work in an environment where automated high-speed motions occur, and consequently, CNC machine tools have to be equipped with safety systems. The approach presented in this paper was to evaluate the main safety systems of CNC machine tools based upon the analytic hierarchy process (AHP). The analyzed systems were divided into six m…

Linguistic impairments in subjects with dementia of the alzheimer’s type: status of the issue

2012

Las personas con demencia de tipo alzhéimer sufren alteraciones lingüísticas. Se han llevado a cabo algunos estudios que describen la naturaleza de este déficit. Los resultados de estos trabajos demuestran que los componentes léxico-semántico y pragmático se encuentran mucho más deteriorados que los niveles fonético-fonológico y morfosintáctico del lenguaje. Nuestro propósito es elaborar un breve estado de la cuestión que nos permita tener una perspectiva global sobre el proceso de deterioro comunicativo. Además, enfatizamos la importancia del análisis lingüístico a la hora de diagnosticar la enfermedad de Alzheimer, ya que se pueden encontrar cambios en las habilidades discursivas desde la…

FETAL GROWTH RESTRICTION: A GROWTH PATTERN WITH FETAL, NEONATAL AND LONG-TERM CONSEQUENCES

2019

Fetal growth restriction (FGR) or intrauterine growth restriction (IUGR) are the terms used for a fetus which has not attained its full growth potential for gestational age. FGR is a multifactorial syndrome responsible for increased fetal and neonatal morbidity and mortality as well as long term adverse outcomes involving auxological, metabolic, organic and functional domains. Clinicians distinguish early and late onset FGR, in relation to specific fetal anthropometric parameters related to the possible primary etiology and to different patterns of placental and maternal cardiovascular pathologies. Delivery of an early onset FGR or growth impaired newborn with congenital pathology should be…

New Insights into the complexation of lead(II) by 1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane (DOTAM): structural, thermodynami…

2007

The lead(II) coordination properties of the tetrapodal ligand DOTAM [1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraaza-cyclododecane] have been investigated both in the solid state and in solution in order to ascertain the stereoactivity of the lone pair and to rationalize the structural effects of a cyclen-based scaffold on the metal uptake kinetics. The crystal structure of the free base shows that the pendant acetamide groups are not equivalent: two are folded over the macrocycle and maintained by an intramolecular hydrogen bond involving an amide hydrogen atom and a neighboring tertiary amine of the cyclen ring, while the other two are extended and point away from the macrocyclic cav…

Play assessment for group settings : validating a measurement tool for assessment of children's play performance in the day-care context

2012

Search for pair production of first or second generation leptoquarks in proton-proton collisions at sqrt(s)=7 TeV using the ATLAS detector at the LHC

2011

This paper describes searches for the pair production of first or second generation scalar leptoquarks using 35  pb−1 of proton-proton collision data recorded by the ATLAS detector at √s=7  TeV. Leptoquarks are searched in events with two oppositely-charged muons or electrons and at least two jets, and in events with one muon or electron, missing transverse momentum and at least two jets. After event selection, the observed yields are consistent with the predicted backgrounds. Leptoquark production is excluded at the 95% CL for masses MLQ<376 (319) GeV and MLQ<422 (362) GeV for first and second generation scalar leptoquarks, respectively, when assuming the branching fraction of a leptoquark…