Search results for "pair"
showing 10 items of 2908 documents
Tenapanor for the treatment of irritable bowel syndrome with constipation.
2020
Introduction: Irritable bowel syndrome with constipation is associated with higher rates of functional impairment, as compared to other subtypes of the syndrome. Conventional laxative-based pharmacologic therapy of IBS-C, which is mostly symptom-based, is often unsatisfactory. Tenapanor represents a first-in-class orally available inhibitor of NHE3, which is minimally absorbed in the GI tract, what constitutes a significant therapeutic benefit, as it may act on the drug target. Areas covered: Aim of this article is to sum up the evidences about pharmacodynamics and pharmacokinetics of tenapanor, focusing on animal models and in vitro studies, but also discuss clinical trials on tenapanor's …
Can cystic lesions of the jaws be considered as the cause of mandibular asymmetry?
2021
The aim of this study is to investigate the presence of condylar and ramal asymmetry in patients with a cyst larger than 10 mm in the maxilla or mandible. Condylar and ramal asymmetry index measurements of 47 patients (mean age: 28.85 ± 15.348) in the study group and 40 patients in the control group (mean age: 33.73 ± 13.095) were performed using panoramic radiographs. The study group consists of patients with cysts larger than 10 mm in diameter in the maxilla or mandible. The control group consisted of patients with no radiolucent lesions and no history of trauma. The possible statistical difference between the groups was evaluated by the Mann-Whitney U test. No statistically significant d…
Cross section for bb¯ production via dielectrons in d + Au collisions at √sNN = 200 GeV
2015
We report a measurement of e+e− pairs from semileptonic heavy-flavor decays in d + Au collisions at √sNN = 200 GeV. By exploring the mass and transverse-momentum dependence of the yield, the bottom decay contribution can be isolated from charm, and quantified by comparison to PYTHIA and MC@NLO simulations. The resulting bb¯-production cross section is σdAu bb¯ = 1.37 ± 0.28 (stat) ± 0.46 (syst) mb, which is equivalent to a nucleon-nucleon cross section of σ NN bb = 3.4 ± 0.8 (stat) ± 1.1 (syst) μb. peerReviewed
Endoluminal stent-graft relining of visceral artery bypass grafts to treat perigraft seroma.
2013
Purpose: To describe the endovascular treatment of intra-abdominal perigraft seromas associated with small-caliber expanded polytetrafluoroethylene (ePTFE) grafts. Case Reports: Two patients who underwent hybrid repair of thoracoabdominal aortic aneurysms in which renovisceral bypass grafts were implanted presented with large, symptomatic perigraft seromas. The 5- to 8-mm-diameter ePTFE bypass grafts believed to be involved in the seromas were successfully relined with self-expanding Viabahn stentgrafts in percutaneous procedures. The patients’ symptoms were relieved, and imaging follow-up (18 and 10 months, respectively) has shown near complete resorption of the seromas. Conclusion: It is …
MutSa expression predicts a lower disease-free survival in malignant salivary gland tumors:an immunohistochemical study
2021
Appropriate DNA replication is vital to maintain cell integrity at the genomic level. Malfunction on DNA repair mechanisms can have implications related to tumor behavior. Our aim was to evaluate the expression of key complexes of the DNA mismatch-repair system MutS? (hMSH2-hMSH6) and MutS? (hMSH2-hMSH3) in a panel comprising the most common benign and malignant salivary gland tumors (SGT), and to determine their association with disease-free survival. Ten cases of normal salivary gland (NSG) and 92 of SGT (54 benign and 38 malignant) were retrieved. Immunohistochemistry was performed for hMSH2, hMSH3, hMSH6. Scanned slides were digitally analyzed based on the percentage of positive cells w…
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
2009
We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10−7), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10−11). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10−15).
The cultural adaptation of Finnish au pairs in England
2002
Joint second-order parameter estimation for spatio-temporal log-Gaussian Cox processes
2018
We propose a new fitting method to estimate the set of second-order parameters for the class of homogeneous spatio-temporal log-Gaussian Cox point processes. With simulations, we show that the proposed minimum contrast procedure, based on the spatio-temporal pair correlation function, provides reliable estimates and we compare the results with the current available methods. Moreover, the proposed method can be used in the case of both separable and non-separable parametric specifications of the correlation function of the underlying Gaussian Random Field. We describe earthquake sequences comparing several Cox model specifications.
Runāšanas prasmju attīstīšana angļu valodas stundās 2. klasē ar pāru metodes palīdzību
2020
Runas attīstība norisinās jau no bērna pirmajiem dzīves gadiem. Parasti tā ir mātes valoda, kurā bērns sāk runāt. Pirmie dzīves gadi ir ļoti nozīmīgi bērna valodas attīstībai, atmiņas apjoms ir liels un iemācītās lietas saglabājās ilgstoši bērna prātā. Tas ir viens no faktoriem, kāpēc svarīgi ir apgūt svešvalodu pirmajās klasēs, jo ieliktie pamati sākumskolā paliks uz mūžu. Kamēr bērns vēl neprot rakstīt, viņam svarīgi ir dzirdēt un sākt pašam runāt. Valodai, kuru bērns dzird ir jābūt pareizi izrunātai, skaidrai, ar pareizām intonācijām. Valodas apguvei jābūt tādai, lai bērns ar lielu prieku gribētu runāt apgūtajā valodā. Diplomdarba mērķis ir izpētīt un analizēt veidus, kā attīstīt, mācīt …
Esteettömyys digitaalisissa ympäristöissä kielellisten erityisvaikeuksien näkökulmasta
2019
Digitalisoitumisen myötä monet arjessa tarvittavat tiedot ja palvelut ovat siirtyneet teknologiaympäristöihin, joiden käyttö vaatii digitaalista lukutaitoa. Tutkimuksessa tarkasteltiin digitaalisten ympäristöjen esteettömyyttä sellaisten nuorten näkökulmasta, joilla on kielellisiä erityisvaikeuksia (SLI). Tutkimus pyrki osallistamaan näitä nuoria digitaalisten palvelujen suunnitteluun. Digitaalisiksi palveluiksi valittiin mielen hyvinvointia edistäviä sivustoja, sovelluksia ja pelejä, koska SLI-nuorilla on todettu muita useammin mielen hyvinvoinnin pulmia. Tutkimustehtävänä oli selvittää, miten digitaalisten ympäristöjen esteettömyys ilmenee tutkimukseen osallistuneiden SLI-nuorten puheissa…