Search results for "progress"
showing 10 items of 1620 documents
Recommendations for eye care during the alarm state by the coronavirus disease pandemic COVID-19.
2020
Abstract Objective Minimize exposure to the SARS-CoV-2, reduce the chances of cross-transmission between patients and healthcare personnel, and prevent the development of postoperative complications from the management of patients with eye diseases during the 2019 coronavirus disease pandemic (COVID-19). Methods COVID-19 literature review and consensus establishment between different Spanish ophthalmology societies in order to provide guidelines and recommendations of maximum resources primarily conditioned by the state of alert, confinement and social distancing that occurs in Spain since March 16, 2020. Results The recommendations will promote the adoption of action and protection measure…
Defective apoptosis and tumorigenesis: role of p53 mutation and Fas/FasL system dysregulation
2010
The transcription factor p53 and the cytokine receptor FasL are two of the most famous regulators of cell life, and their alterations can cause a large number of pathologies, including cancer. In this review, we focused on how they can determine defective apoptosis, one of the causes of tumorigenesis and tumor progression. The importance of this knowledge lies in the new perspectives that gene therapy can offer to cure cancer.
DEVELOPMENT OF LATVIAN AUTO ROADS AND ADMINISTRATIVE SYSTEM IMPROVEMENT
2012
Auto road sector in national economy, is a sector development of which, with appropriate funding, creates basis for other sector development and facilitates competitiveness of country in international market. The goal of auto road sector is auto road network maintenance and development, in order to contribute to the development of the whole country, increase of standards of living of inhabitants, as well as facilitate compliance of Latvian auto roads with the European Union requirements for auto road network. Effective resource utilization and investment attraction to auto road sector is determinant for favorable conditions to overcome economic crisis, structural changes in national econom…
The History of European Infrastructure Finance: An Analytical Framework
2016
How can socio-economic resources be mobilized to pay for works that offer benefits only in the future, often in the distant future? We discuss what we understand by infrastructure, a term that can have different meanings/semantic contents, and whose definition issues reveal some recurrent conceptual problems. Finance is here understood in the very broad sense of a set of mechanisms bringing to investment, and future benefits, the resources needed in advance to pay for it. We offer a brief discussion of technological and organizational change, as several of our examples and other literature that we cite show that investment and finance decisions are deeply interwoven with knowledge, manageme…
Staging systems in bipolar disorder: an International Society for Bipolar Disorders Task Force Report
2014
Objective: We discuss the rationale behind staging systems described specifically for bipolar disorders. Current applications, future directions and research gaps in clinical staging models for bipolar disorders are outlined. Method: We reviewed the literature pertaining to bipolar disorders, focusing on the first episode onwards. We systematically searched data on staging models for bipolar disorders and allied studies that could inform the concept of staging. Results: We report on several dimensions that are relevant to staging concepts in bipolar disorder. We consider whether staging offers a refinement to current diagnoses by reviewing clinical studies of treatment and functioning and t…
The Influence of Infective Dose on the Virulence of a Generalist Pathogen in Rainbow Trout (Oncorhynchus mykiss) and Zebra Fish (Danio rerio)
2015
Pathogen density and genetic diversity fluctuate in the outside-host environment during and between epidemics, affecting disease emergence and the severity and probability of infections. Although the importance of these factors for pathogen virulence and infection probability has been acknowledged, their interactive effects are not well understood. We studied how an infective dose in an environmentally transmitted opportunistic fish pathogen, Flavobacterium columnare, affects its virulence both in rainbow trout, which are frequently infected at fish farms, and in zebra fish, a host that is not naturally infected by F. columnare. We used previously isolated strains of confirmed high and low …
Racism, Xenophobia and Intolerance
2015
Unlike what is usually assumed, racism is neither a phenomenon of the past nor exclusive to other latitudes. As Wieviorka points out (2009, p. 15), today there has been a surprising return of racism, even in societies that could be expected to be ridding themselves of it. Until the 1960s, the outlook clearly seemed optimistic, as the prevailing idea was that political and economic progress would end up burying phenomena of this type. This hypothesis, however, was soon revealed to be overly optimistic. Racism currently exists in European societies, and it is one of the great challenges of their present and future. Therefore, regardless of future social evolution, it is likely that European s…
Hepatobiliary phase hypointensity predicts progression to hepatocellular carcinoma for intermediate-high risk observations, but not time to progressi…
2020
Purpose: To determine whether hepatobiliary phase hypointensity, enhancing “capsule” and size provide prognostic information regarding the risk of progression to hepatocellular carcinoma (HCC), as well as the time to progression, of intermediate to high risk observations ≥ 10 mm with arterial phase hyperenhancement (APHE). Method: This retrospective dual-institution study included 160 LR-3 and 26 LR-4 observations measuring more than 10 mm and having APHE in 136 patients (mean age [SD], 57 [11] years old). A composite reference standard of pathologic analysis and imaging follow-up was used. The prognostic performance of hepatobiliary phase hypointensity, enhancing “capsule” and size (cut-of…
The “Janus” Role of C/EBPs Family Members in Cancer Progression
2020
CCAAT/enhancer-binding proteins (C/EBPs) constitute a family of transcription factors composed of six members that are critical for normal cellular differentiation in a variety of tissues. They promote the expression of genes through interaction with their promoters. Moreover, they have a key role in regulating cellular proliferation through interaction with cell cycle proteins. C/EBPs are considered to be tumor suppressor factors due to their ability to arrest cell growth (contributing to the terminal differentiation of several cell types) and for their role in cellular response to DNA damage, nutrient deprivation, hypoxia, and genotoxic agents. However, C/EBPs can elicit completely opposi…
Constructive Dynamic Program Slicing Research
2010
Program slicing is a promising technique for providing automated support for various important software engineering activities. There exists hundreds of scientific studies on the theory of slicing. However, slicing is still not widely applied in software industry. Therefore, there is a need to survey and characterize the conducted research and to analyze what problems hinder progress. This paper answers to that need by providing a survey of constructive dynamic program slicing research focusing on publication series with high visibility. The survey identified 12 dynamic slicers related to which 12 aspects were studied. The analysis revealed many issues which can be seen both as concerns and…