Search results for "recurso"
showing 10 items of 734 documents
PluriTAV: desarrollo de las competencias plurilingües mediante el uso de la traducción audiovisual
2018
[EN] This piece of work introduces the PluriTAV (Audiovisual Translation as a Tool for the Development of Multilingual Competences in the Classroom) research project. This project is staked on one of the most recent approaches of foreign language teaching, the multilingual approach, in which not only the language being studied (or taught) but also the linguistic repertoire of the classroom are taken into account. The project, focused on the teaching and perfecting of language, is based on the said approach and draws on a field related to foreign language teaching, audiovisual translation, so that through it, one can learn a foreign language, perfect mother tongue abilities and develop multi…
Experiencias de aprendizaje del Derecho del Trabajo a través del cine
2020
[ES] Este artículo analiza la experiencia realizada durante tres años con objeto de complementar la enseñanza del Derecho del trabajo con el uso del cine como material bibiográfico y sus resultados. En la experiencia se propuso una película por cada tema del programa académico de la asignatura de Derecho del trabajo (I) y también de la asignatura Políticas sociolaborales, ocupación e igualdad. Los resultados han sido positivos siendo el material cinemátográfico una ayuda significativa a la comprensión de conceptos complejos y su retención en el tiempo.
Different mechanisms of resistance to Bacillus thuringiensis toxins in the indianmeal moth.
2001
ABSTRACT Susceptibility to protoxin and toxin forms of Cry1Ab and the binding of 125 I-labeled Cry1Ab and Cry1Ac has been examined in three Plodia interpunctella colonies, one susceptible (688 s ) and two resistant (198 r and Dpl r ) to Bacillus thuringiensis . Toxicological studies showed that the 198 r colony was 11-fold more resistant to Cry1Ab protoxin than to Cry1Ab activated toxin, whereas the Dpl r colony was 4-fold more resistant to protoxin versus toxin. Binding results with 125 I-labeled toxins indicated the occurrence of two different binding sites for Cry1Ab in the susceptible insects, one of them shared with Cry1Ac. Cry1Ab binding was found to be altered in insects from both re…
Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition.
2020
AbstractAmyloid-β precursor protein (APP) is central to the pathogenesis of Alzheimer’s disease, yet its physiological functions remain incompletely understood. Previous studies had indicated important synaptic functions of APP and the closely related homologue APLP2 in excitatory forebrain neurons for spine density, synaptic plasticity, and behavior. Here, we show that APP is also widely expressed in several interneuron subtypes, both in hippocampus and cortex. To address the functional role of APP in inhibitory neurons, we generated mice with a conditional APP/APLP2 double knockout (cDKO) in GABAergic forebrain neurons using DlxCre mice. These DlxCre cDKO mice exhibit cognitive deficits i…
Manual sobre la violencia contra las mujeres. Guia de información para la mujer en situación de abuso
2003
Se trata de una guia de información para mujeres y profesionales sobre como actuar en caso de violencia de género y que medidas tomar.
Menores criados por sus abuelas. Mejora de la pautas de cuidado a menores en acogimiento familiar en familia extensa a través de un programa de inter…
2011
[EN] In this research we have tried to describe the fostering kinship with grandparents as an alternative to living together in cases in which parents cannot play or stop playing their roles of main caregivers of their own children. This diversity ranges from multiproblematical and risky families, in which the situations of neglect and unprotection of minors prevail, to the care of minors due to more normalized causes (like parents death, divorce, etc.) The impact of this family situation on grandparents requires an special attention, due to problems related to the restructuring of roles, i.e. turning grandparents into substitute parents. The prevention of the emergence of negative conseque…
Asignación de recursos y estructura de gastos en la universidad
1988
National audience
Melittin Modulates Keratinocyte Function through P2 Receptor-dependent ADAM Activation
2012
Melittin, the major component of the bee venom, is an amphipathic, cationic peptide with a wide spectrum of biological properties that is being considered as an anti-inflammatory and anti-cancer agent. It modulates multiple cellular functions but the underlying mechanisms are not clearly understood. Here, we report that melittin activates disintegrin-like metalloproteases (ADAMs) and that downstream events likely contribute to the biological effects evoked by the peptide. Melittin stimulated the proteolysis of ADAM10 and ADAM17 substrates in human neutrophil granulocytes, endothelial cells and murine fibroblasts. In human HaCaT keratinocytes, melittin induced shedding of the adhesion molecu…
Unsaturated Fatty Acids Drive Disintegrin and Metalloproteinase (ADAM)-dependent Cell Adhesion, Proliferation, and Migration by Modulating Membrane F…
2011
The disintegrin-metalloproteinases ADAM10 and ADAM17 mediate the release of several cell signaling molecules and cell adhesion molecules such as vascular endothelial cadherin or L-selectin affecting endothelial permeability and leukocyte transmigration. Dysregulation of ADAM activity may contribute to the pathogenesis of vascular diseases, but the mechanisms underlying the control of ADAM functions are still incompletely understood. Atherosclerosis is characterized by lipid plaque formation and local accumulation of unsaturated free fatty acids (FFA). Here, we show that unsaturated FFA increase ADAM-mediated substrate cleavage. We demonstrate that these alterations are not due to genuine ch…
Proteomic Analyses Reveal an Acidic Prime Side Specificity for the Astacin Metalloprotease Family Reflected by Physiological Substrates
2011
Astacins are secreted and membrane-bound metalloproteases with clear associations to many important pathological and physiological processes. Yet with only a few substrates described their biological roles are enigmatic. Moreover, the lack of knowledge of astacin cleavage site specificities hampers assay and drug development. Using PICS (proteomic identification of protease cleavage site specificity) and TAILS (terminal amine isotopic labeling of substrates) degradomics approaches >3000 cleavage sites were proteomically identified for five different astacins. Such broad coverage enables family-wide determination of specificities N- and C-terminal to the scissile peptide bond. Remarkably, me…